ID   S40A_CHITE              Reviewed;         244 AA.
AC   Q05018;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Salivary gland SP38-40.A protein;
DE   Flags: Precursor;
GN   Name=SP38-40.A;
OS   Chironomus tentans (Midge) (Camptochironomus tentans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC   Chironominae; Chironomus.
OX   NCBI_TaxID=7153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8510150; DOI=10.1006/jmbi.1993.1285;
RA   Galli J., Wieslander L.;
RT   "Two secretory protein genes in Chironomus tentans have arisen by gene
RT   duplication and exhibit different developmental expression patterns.";
RL   J. Mol. Biol. 231:324-334(1993).
CC   -!- FUNCTION: Used by the larvae to construct a supramolecular structure,
CC       the larval tube.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Salivary gland.
CC   -!- DEVELOPMENTAL STAGE: Expression of the SP38-40.a and B genes are
CC       different: the A gene is expressed throughout the larval fourth instar
CC       but considerably less in the prepupal stage, while the B gene shows the
CC       opposite expression pattern.
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DR   EMBL; X70063; CAA49667.1; -; Genomic_DNA.
DR   PIR; S33819; S33819.
DR   AlphaFoldDB; Q05018; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..244
FT                   /note="Salivary gland SP38-40.A protein"
FT                   /id="PRO_0000022263"
FT   REPEAT          29..34
FT                   /note="1-1"
FT   REPEAT          35..40
FT                   /note="1-2"
FT   REPEAT          41..47
FT                   /note="1-3; approximate"
FT   REPEAT          156..159
FT                   /note="2-1"
FT   REPEAT          161..164
FT                   /note="2-2"
FT   REPEAT          165..168
FT                   /note="2-3; approximate"
FT   REPEAT          225..228
FT                   /note="3-1"
FT   REPEAT          229..232
FT                   /note="3-2"
FT   REPEAT          233..236
FT                   /note="3-3"
FT   REPEAT          237..240
FT                   /note="3-4; approximate"
FT   REGION          23..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          29..47
FT                   /note="3 X 6 AA approximate tandem repeats of K-P-K-D-A-P"
FT   REGION          137..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          156..168
FT                   /note="3 X 4 AA approximate tandem repeats of K-P-P-K"
FT   REGION          206..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          225..240
FT                   /note="4 X 4 AA approximate tandem repeats of P-K-[PQ]-
FT                   [GA]"
FT   COMPBIAS        28..91
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..169
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..223
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         30
FT                   /note="P -> T (in allele A:2)"
FT   VARIANT         40
FT                   /note="P -> PKPKEEP (in allele A:2)"
FT   VARIANT         166
FT                   /note="L -> P (in allele A:2)"
FT   VARIANT         229..232
FT                   /note="Missing (in allele A:2)"
SQ   SEQUENCE   244 AA;  27374 MW;  85438526C1146952 CRC64;
     MRIKFLVVLA VICLFAHYAS ASGMGGDKKP KDAPKPKDAP KPKEVKPVKA ESSEYEIEVI
     KHQKEKTEKK EKEKKTHVET KKEVKKKEKK QIPCSEKLKD EKLDCETKGV PAGYKAIFKF
     TENEECDWTC DYEALPPPPG AKKDDKKEKK TVKVVKPPKE KPPKKLRKEC SGEKVIKFQN
     CLVKIRGLIA FGDKTKNFDK KFAKLVQGKQ KKGAKKAKGG KKAAPKPGPK PGPKQADKPK
     DAKK