ID   BEST5_CAEEL             Reviewed;         453 AA.
AC   P34319;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Bestrophin homolog 5;
GN   Name=best-5; ORFNames=C07A9.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Forms chloride channels. {ECO:0000250}.
CC   -!- SUBUNIT: Forms oligomers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
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DR   EMBL; Z29094; CAA82342.2; -; Genomic_DNA.
DR   PIR; S40708; S40708.
DR   RefSeq; NP_499142.2; NM_066741.3.
DR   AlphaFoldDB; P34319; -.
DR   SMR; P34319; -.
DR   STRING; 6239.C07A9.8; -.
DR   EPD; P34319; -.
DR   PaxDb; P34319; -.
DR   EnsemblMetazoa; C07A9.8.1; C07A9.8.1; WBGene00007404.
DR   GeneID; 176367; -.
DR   KEGG; cel:CELE_C07A9.8; -.
DR   UCSC; C07A9.8; c. elegans.
DR   CTD; 176367; -.
DR   WormBase; C07A9.8; CE33596; WBGene00007404; best-5.
DR   eggNOG; KOG3547; Eukaryota.
DR   GeneTree; ENSGT00970000196383; -.
DR   HOGENOM; CLU_018069_7_1_1; -.
DR   InParanoid; P34319; -.
DR   OMA; QIRRNII; -.
DR   OrthoDB; 279144at2759; -.
DR   PhylomeDB; P34319; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   PRO; PR:P34319; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00007404; Expressed in adult organism and 1 other tissue.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   InterPro; IPR000615; Bestrophin.
DR   InterPro; IPR021134; Bestrophin/UPF0187.
DR   PANTHER; PTHR10736; PTHR10736; 1.
DR   Pfam; PF01062; Bestrophin; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..453
FT                   /note="Bestrophin homolog 5"
FT                   /id="PRO_0000143126"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   453 AA;  52830 MW;  D8DB9F1742C5DEEC CRC64;
     MTNNNDPKCV VIEEPDDVPV KPPKIFDFTD WPFEIPDIFK RKELSYNYNY DLATSKSLMI
     VRMIFKWRGS LWQAVYKELI VWICAYSLVS VIYRFALTRS QKDIFERFGE YCDARMGYLP
     LNFVLGFFCN IIIRRWLKLY TSLGNIDNIA LFVSAYVRGT DDRARQIRRN IIRYCVISQC
     LVFRDIHVGV RRRFPTLEAV AQAGIMLPHE LEKFNSIKSR YQKYWVSFNW ALELLNVAKT
     EKSIDGDNAR NAIAQEISKF RSALTTVSMY DWVPIPLMYP QLVNMAVHTY FFLCIFTRQF
     FISADAHNKT EVDLYIPFMT IIEFIFYMGW LKVAMELLNP FGEDADDFDC NLLIDRNLAI
     GLTSVDDAYD QLPEVKPDVF TGGSVKPLDS DDTRSLKYHF GSAAQMEEIS YLKKEENKMI
     AAGKKPNKLK LWVKSVRRKR FETSATQPSF PIP