S41A1_DANRE
ID S41A1_DANRE Reviewed; 544 AA.
AC E7EXX2;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Solute carrier family 41 member 1;
GN Name=slc41a1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP DISRUPTION PHENOTYPE.
RX PubMed=23661805; DOI=10.1681/asn.2012101034;
RA Hurd T.W., Otto E.A., Mishima E., Gee H.Y., Inoue H., Inazu M., Yamada H.,
RA Halbritter J., Seki G., Konishi M., Zhou W., Yamane T., Murakami S.,
RA Caridi G., Ghiggeri G., Abe T., Hildebrandt F.;
RT "Mutation of the Mg2+ transporter SLC41A1 results in a nephronophthisis-
RT like phenotype.";
RL J. Am. Soc. Nephrol. 24:967-977(2013).
CC -!- FUNCTION: Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+)
CC efflux system at the plasma membrane (By similarity). Transporter
CC activity is driven by the inwardly directed electrochemical gradient
CC for Na(+) ions, thus directly depends on the extracellular Na(+) ion
CC concentration set by Na(+)/K(+) pump (By similarity).
CC {ECO:0000250|UniProtKB:Q8IVJ1}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Mg(2+)(in) + 2 Na(+)(out) = Mg(2+)(out) + 2 Na(+)(in);
CC Xref=Rhea:RHEA:66616, ChEBI:CHEBI:18420, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000250|UniProtKB:Q8IVJ1};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66617;
CC Evidence={ECO:0000250|UniProtKB:Q8IVJ1};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IVJ1};
CC Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane
CC {ECO:0000250|UniProtKB:Q8IVJ1}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein results in
CC ventral body curvature, hydrocephalus, and cystic kidneys.
CC {ECO:0000269|PubMed:23661805}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family. {ECO:0000305}.
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DR EMBL; AL928854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX004882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002663867.1; XM_002663821.5.
DR RefSeq; XP_009304534.1; XM_009306259.2.
DR STRING; 7955.ENSDARP00000093644; -.
DR PaxDb; E7EXX2; -.
DR Ensembl; ENSDART00000102870.5; ENSDARP00000093644.3; ENSDARG00000070214.5.
DR Ensembl; ENSDART00000187259.1; ENSDARP00000151779.1; ENSDARG00000114707.1.
DR Ensembl; ENSDART00000192096.1; ENSDARP00000147185.1; ENSDARG00000070214.5.
DR GeneID; 325975; -.
DR KEGG; dre:325975; -.
DR CTD; 254428; -.
DR ZFIN; ZDB-GENE-030131-4700; slc41a1.
DR eggNOG; KOG3788; Eukaryota.
DR GeneTree; ENSGT00950000183042; -.
DR HOGENOM; CLU_018207_3_1_1; -.
DR InParanoid; E7EXX2; -.
DR OMA; YLERDDW; -.
DR OrthoDB; 1059294at2759; -.
DR TreeFam; TF313647; -.
DR Reactome; R-DRE-425410; Metal ion SLC transporters.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 11.
DR Bgee; ENSDARG00000070214; Expressed in liver and 11 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0061768; F:magnesium:sodium antiporter activity; ISS:UniProtKB.
DR GO; GO:0043009; P:chordate embryonic development; IMP:ZFIN.
DR GO; GO:0010960; P:magnesium ion homeostasis; IMP:ZFIN.
DR GO; GO:0048793; P:pronephros development; IMP:ZFIN.
DR Gene3D; 1.10.357.20; -; 2.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR InterPro; IPR045349; SLC41A1-3.
DR PANTHER; PTHR16228; PTHR16228; 1.
DR Pfam; PF01769; MgtE; 2.
DR SUPFAM; SSF161093; SSF161093; 2.
PE 3: Inferred from homology;
KW Cell membrane; Ion transport; Magnesium; Membrane; Phosphoprotein;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..544
FT /note="Solute carrier family 41 member 1"
FT /id="PRO_0000455805"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 471..491
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 544 AA; 58779 MW; 7CD1E407B831E18A CRC64;
MVLWLKDQDK LSDMSTGTER IEMKKEGVPP AYHHSNGSVH PVILPDSPEE VPQTPGEYEL
TEVTSLPDCG DQENERPDMV VLDCRANAKG QREEDALLEN ASQSNESDDT STDQSPVPPA
PLKETSFSIG LQVLIPFLLA GFGTVAAGMV LDIVQHWTVF TEVTEVFILV PALLGLKGNL
EMTLASRLST AANIGQMDTA KDMWKMIMGN LALIQVQATV VGFLASIAAV IFGWIPEGNF
RMGHAILLCA SSVATAFIAS LALGLIMIGV IIASRKVGIN PDNVATPIAA SLGDLITLSL
LAGISTGLYK ELEFNNYANP MVCAFFVALT PIWVLIARRI PSTREVLYSG WEPVIIAMAI
SSVGGLILDK TVSNPNFAGM AVFTPVINGV GGNLVAVQAS RISTYLHMNA LPIVEPNPAP
RKCPTPWGTF FGSGVNSRSA KVLFLLVAPG HLVFLYTINS MRGGHTTLTY IFIAFYLAAA
LLQVIILLYL ADWMVNWMWR RGMDPDNFSI PYLTALGDLL GTGFLALCFH ILWLIGDRDT
DVGD
