ID   S41A2_CHICK             Reviewed;         573 AA.
AC   Q5ZHX6;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Solute carrier family 41 member 2;
GN   Name=SLC41A2; ORFNames=RCJMB04_32e4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Acts as a plasma-membrane magnesium transporter.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the SLC41A transporter family. {ECO:0000305}.
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DR   EMBL; AJ721008; CAG32667.1; -; mRNA.
DR   RefSeq; NP_001026654.1; NM_001031483.1.
DR   AlphaFoldDB; Q5ZHX6; -.
DR   STRING; 9031.ENSGALP00000042624; -.
DR   PaxDb; Q5ZHX6; -.
DR   GeneID; 427913; -.
DR   KEGG; gga:427913; -.
DR   CTD; 84102; -.
DR   VEuPathDB; HostDB:geneid_427913; -.
DR   eggNOG; KOG3788; Eukaryota.
DR   InParanoid; Q5ZHX6; -.
DR   OrthoDB; 1059294at2759; -.
DR   PhylomeDB; Q5ZHX6; -.
DR   PRO; PR:Q5ZHX6; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.357.20; -; 2.
DR   InterPro; IPR006667; SLC41_membr_dom.
DR   InterPro; IPR036739; SLC41_membr_dom_sf.
DR   InterPro; IPR045349; SLC41A1-3.
DR   PANTHER; PTHR16228; PTHR16228; 1.
DR   Pfam; PF01769; MgtE; 2.
DR   SUPFAM; SSF161093; SSF161093; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Magnesium; Membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..573
FT                   /note="Solute carrier family 41 member 2"
FT                   /id="PRO_0000295043"
FT   TOPO_DOM        1..162
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..195
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..245
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        267..282
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        304..313
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        335..347
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        369..376
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        398..406
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        428..469
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        470..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        491..499
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        500..520
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        521..543
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        544..564
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        565..573
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   573 AA;  62406 MW;  B08CBA70457D5F2C CRC64;
     MTNCKGRSTI TKTNSKVHDR EGFVNWTISL STVQSDKFLN LLLSMVPVVY QINQDERHKK
     VNGVWQDGLQ PAGHNYNVKS DQHVEYHHFS EQTFHGSNGH SPSSCSPKYD DFSSYNYCDG
     MDASETDAML QEDNISSDSN EDIIVEGIRK QPKESSSIMA LQILVPFLLA GFGTVTAGMV
     LDIVQHWDVF KNVTEVFILV PALLGLKGNL EMTLASRLST AVNIGKMDSP IEKWNLIIGN
     LALKQVQATV VGFLAAVAAV ILGWIPEGKY SFSHSILLCS SSVATAFIAS LLQGIIMVGV
     IVGSKKTGIN PDNVATPIAA SFGDLITLAI LAWISQGLYT CLETYYYVSP LVGAFFLALT
     PMGIVIAAKH PATRTVLHSG WEPVITAMII SSIGGLILDT TVSDPNLVGI VVYTPVINGI
     GGNLVAIQAS RISTYLHLHS IPGELPEEAK GCYYPCRTYY GTGVNNKSAQ VLLLLVIPGH
     LIFLYTIHLM KSGHTSLTPI FIAVYLFAAL LQVFTLLWIA DWMVHHFWKK GKDPDSFSIP
     YLTALGDLLG TALLAVGFHF LWLIGDRDGD VGD