S41A2_HUMAN
ID S41A2_HUMAN Reviewed; 573 AA.
AC Q96JW4; Q3KP68; Q9H0E5;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Solute carrier family 41 member 2;
GN Name=SLC41A2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-573.
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [4]
RP FUNCTION, TOPOLOGY, AND SUBCELLULAR LOCATION.
RX PubMed=16984228; DOI=10.1042/bj20060673;
RA Sahni J., Nelson B., Scharenberg A.M.;
RT "SLC41A2 encodes a plasma-membrane Mg2+ transporter.";
RL Biochem. J. 401:505-513(2007).
CC -!- FUNCTION: Acts as a plasma-membrane magnesium transporter.
CC {ECO:0000269|PubMed:16984228}.
CC -!- INTERACTION:
CC Q96JW4; Q86WK6: AMIGO1; NbExp=3; IntAct=EBI-10290130, EBI-19125216;
CC Q96JW4; Q13520: AQP6; NbExp=3; IntAct=EBI-10290130, EBI-13059134;
CC Q96JW4; P11912: CD79A; NbExp=3; IntAct=EBI-10290130, EBI-7797864;
CC Q96JW4; A0A024R644: CLN5; NbExp=3; IntAct=EBI-10290130, EBI-12838990;
CC Q96JW4; Q15125: EBP; NbExp=3; IntAct=EBI-10290130, EBI-3915253;
CC Q96JW4; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-10290130, EBI-781551;
CC Q96JW4; P60508: ERVFRD-1; NbExp=3; IntAct=EBI-10290130, EBI-17973325;
CC Q96JW4; Q969F0: FATE1; NbExp=3; IntAct=EBI-10290130, EBI-743099;
CC Q96JW4; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-10290130, EBI-12142257;
CC Q96JW4; P21217: FUT3; NbExp=3; IntAct=EBI-10290130, EBI-12839380;
CC Q96JW4; P36382: GJA5; NbExp=3; IntAct=EBI-10290130, EBI-750433;
CC Q96JW4; O95377: GJB5; NbExp=3; IntAct=EBI-10290130, EBI-3909454;
CC Q96JW4; Q8TDV0: GPR151; NbExp=3; IntAct=EBI-10290130, EBI-11955647;
CC Q96JW4; O15529: GPR42; NbExp=3; IntAct=EBI-10290130, EBI-18076404;
CC Q96JW4; Q8TED1: GPX8; NbExp=3; IntAct=EBI-10290130, EBI-11721746;
CC Q96JW4; Q9UM44: HHLA2; NbExp=3; IntAct=EBI-10290130, EBI-2867874;
CC Q96JW4; P24593: IGFBP5; NbExp=3; IntAct=EBI-10290130, EBI-720480;
CC Q96JW4; Q6UWB1: IL27RA; NbExp=3; IntAct=EBI-10290130, EBI-19045531;
CC Q96JW4; Q8N6L0: KASH5; NbExp=6; IntAct=EBI-10290130, EBI-749265;
CC Q96JW4; Q8N743: KIR3DL3; NbExp=3; IntAct=EBI-10290130, EBI-17272405;
CC Q96JW4; Q5T700: LDLRAD1; NbExp=3; IntAct=EBI-10290130, EBI-10173166;
CC Q96JW4; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-10290130, EBI-17490413;
CC Q96JW4; Q9H400: LIME1; NbExp=3; IntAct=EBI-10290130, EBI-2830566;
CC Q96JW4; O95867: LY6G6C; NbExp=3; IntAct=EBI-10290130, EBI-9088345;
CC Q96JW4; Q9Y5Y7: LYVE1; NbExp=3; IntAct=EBI-10290130, EBI-10329546;
CC Q96JW4; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-10290130, EBI-11956541;
CC Q96JW4; Q9BQ51: PDCD1LG2; NbExp=3; IntAct=EBI-10290130, EBI-16427978;
CC Q96JW4; P15151: PVR; NbExp=3; IntAct=EBI-10290130, EBI-3919694;
CC Q96JW4; Q3SXP7: SHISAL1; NbExp=3; IntAct=EBI-10290130, EBI-18037857;
CC Q96JW4; Q9H2J7: SLC6A15; NbExp=3; IntAct=EBI-10290130, EBI-11343466;
CC Q96JW4; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-10290130, EBI-17280858;
CC Q96JW4; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-10290130, EBI-10982110;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16984228};
CC Multi-pass membrane protein {ECO:0000269|PubMed:16984228}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH36734.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI06872.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI06873.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB55402.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAB66762.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK027838; BAB55402.1; ALT_FRAME; mRNA.
DR EMBL; BC036734; AAH36734.1; ALT_INIT; mRNA.
DR EMBL; BC106871; AAI06872.2; ALT_INIT; mRNA.
DR EMBL; BC106872; AAI06873.2; ALT_INIT; mRNA.
DR EMBL; AL136828; CAB66762.1; ALT_INIT; mRNA.
DR CCDS; CCDS9100.2; -.
DR RefSeq; NP_115524.3; NM_032148.3.
DR RefSeq; XP_005269233.1; XM_005269176.1.
DR RefSeq; XP_005269235.1; XM_005269178.1.
DR RefSeq; XP_005269236.1; XM_005269179.1.
DR RefSeq; XP_006719693.1; XM_006719630.2.
DR RefSeq; XP_011537109.1; XM_011538807.2.
DR RefSeq; XP_011537110.1; XM_011538808.1.
DR RefSeq; XP_011537111.1; XM_011538809.1.
DR RefSeq; XP_011537112.1; XM_011538810.2.
DR RefSeq; XP_011537113.1; XM_011538811.2.
DR RefSeq; XP_016875502.1; XM_017020013.1.
DR AlphaFoldDB; Q96JW4; -.
DR BioGRID; 123891; 39.
DR IntAct; Q96JW4; 32.
DR STRING; 9606.ENSP00000258538; -.
DR TCDB; 1.A.26.2.2; the mg(2+) transporter-e (mgte) family.
DR GlyGen; Q96JW4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96JW4; -.
DR PhosphoSitePlus; Q96JW4; -.
DR BioMuta; SLC41A2; -.
DR DMDM; 152112286; -.
DR EPD; Q96JW4; -.
DR jPOST; Q96JW4; -.
DR MassIVE; Q96JW4; -.
DR MaxQB; Q96JW4; -.
DR PaxDb; Q96JW4; -.
DR PeptideAtlas; Q96JW4; -.
DR PRIDE; Q96JW4; -.
DR ProteomicsDB; 77010; -.
DR Antibodypedia; 30606; 150 antibodies from 17 providers.
DR DNASU; 84102; -.
DR Ensembl; ENST00000258538.8; ENSP00000258538.3; ENSG00000136052.10.
DR GeneID; 84102; -.
DR KEGG; hsa:84102; -.
DR MANE-Select; ENST00000258538.8; ENSP00000258538.3; NM_001352171.3; NP_001339100.1.
DR UCSC; uc001tla.4; human.
DR CTD; 84102; -.
DR DisGeNET; 84102; -.
DR GeneCards; SLC41A2; -.
DR HGNC; HGNC:31045; SLC41A2.
DR HPA; ENSG00000136052; Tissue enhanced (liver).
DR MIM; 610802; gene.
DR neXtProt; NX_Q96JW4; -.
DR OpenTargets; ENSG00000136052; -.
DR PharmGKB; PA134931432; -.
DR VEuPathDB; HostDB:ENSG00000136052; -.
DR eggNOG; KOG3788; Eukaryota.
DR GeneTree; ENSGT00950000183042; -.
DR HOGENOM; CLU_018207_3_0_1; -.
DR InParanoid; Q96JW4; -.
DR OMA; VQSDKFL; -.
DR OrthoDB; 1059294at2759; -.
DR PhylomeDB; Q96JW4; -.
DR TreeFam; TF313647; -.
DR PathwayCommons; Q96JW4; -.
DR Reactome; R-HSA-425410; Metal ion SLC transporters.
DR SignaLink; Q96JW4; -.
DR BioGRID-ORCS; 84102; 9 hits in 1070 CRISPR screens.
DR ChiTaRS; SLC41A2; human.
DR GenomeRNAi; 84102; -.
DR Pharos; Q96JW4; Tbio.
DR PRO; PR:Q96JW4; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q96JW4; protein.
DR Bgee; ENSG00000136052; Expressed in calcaneal tendon and 159 other tissues.
DR ExpressionAtlas; Q96JW4; baseline and differential.
DR Genevisible; Q96JW4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; TAS:Reactome.
DR Gene3D; 1.10.357.20; -; 2.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR InterPro; IPR045349; SLC41A1-3.
DR PANTHER; PTHR16228; PTHR16228; 1.
DR Pfam; PF01769; MgtE; 2.
DR SUPFAM; SSF161093; SSF161093; 2.
PE 1: Evidence at protein level;
KW Cell membrane; Ion transport; Magnesium; Membrane; Phosphoprotein;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..573
FT /note="Solute carrier family 41 member 2"
FT /id="PRO_0000295040"
FT TOPO_DOM 1..162
FT /note="Extracellular"
FT /evidence="ECO:0000269|PubMed:16984228"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..195
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:16984228"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..245
FT /note="Extracellular"
FT /evidence="ECO:0000269|PubMed:16984228"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..282
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:16984228"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..313
FT /note="Extracellular"
FT /evidence="ECO:0000269|PubMed:16984228"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:16984228"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..376
FT /note="Extracellular"
FT /evidence="ECO:0000269|PubMed:16984228"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 398..406
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:16984228"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 428..469
FT /note="Extracellular"
FT /evidence="ECO:0000269|PubMed:16984228"
FT TRANSMEM 470..490
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 491..498
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:16984228"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 520..543
FT /note="Extracellular"
FT /evidence="ECO:0000269|PubMed:16984228"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 565..573
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:16984228"
FT MOD_RES 136
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BYR8"
FT MOD_RES 137
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BYR8"
FT CONFLICT 115
FT /note="Y -> C (in Ref. 1; BAB55402)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 573 AA; 62473 MW; 1BD0FF32AF91DA02 CRC64;
MTNSKGRSIT DKTSGGPSSG GGFVDWTLRL NTIQSDKFLN LLLSMVPVIY QKNQEDRHKK
ANGIWQDGLS TAVQTFSNRS EQHMEYHSFS EQSFHANNGH ASSSCSQKYD DYANYNYCDG
RETSETTAML QDEDISSDGD EDAIVEVTPK LPKESSGIMA LQILVPFLLA GFGTVSAGMV
LDIVQHWEVF RKVTEVFILV PALLGLKGNL EMTLASRLST AVNIGKMDSP IEKWNLIIGN
LALKQVQATV VGFLAAVAAI ILGWIPEGKY YLDHSILLCS SSVATAFIAS LLQGIIMVGV
IVGSKKTGIN PDNVATPIAA SFGDLITLAI LAWISQGLYS CLETYYYISP LVGVFFLALT
PIWIIIAAKH PATRTVLHSG WEPVITAMVI SSIGGLILDT TVSDPNLVGI VVYTPVINGI
GGNLVAIQAS RISTYLHLHS IPGELPDEPK GCYYPFRTFF GPGVNNKSAQ VLLLLVIPGH
LIFLYTIHLM KSGHTSLTII FIVVYLFGAV LQVFTLLWIA DWMVHHFWRK GKDPDSFSIP
YLTALGDLLG TALLALSFHF LWLIGDRDGD VGD
