S41A2_MACFA
ID S41A2_MACFA Reviewed; 573 AA.
AC Q4R335;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 50.
DE RecName: Full=Solute carrier family 41 member 2;
GN Name=SLC41A2; ORFNames=QtsA-19941;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a plasma-membrane magnesium transporter.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family. {ECO:0000305}.
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DR EMBL; AB179433; BAE02484.1; -; mRNA.
DR RefSeq; NP_001270929.1; NM_001284000.1.
DR AlphaFoldDB; Q4R335; -.
DR STRING; 9541.XP_005572134.1; -.
DR Ensembl; ENSMFAT00000028899; ENSMFAP00000000728; ENSMFAG00000045731.
DR GeneID; 101866105; -.
DR CTD; 84102; -.
DR eggNOG; KOG3788; Eukaryota.
DR GeneTree; ENSGT00950000183042; -.
DR OrthoDB; 1059294at2759; -.
DR Proteomes; UP000233100; Chromosome 11.
DR Bgee; ENSMFAG00000045731; Expressed in liver and 11 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0030001; P:metal ion transport; IEA:Ensembl.
DR Gene3D; 1.10.357.20; -; 2.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR InterPro; IPR045349; SLC41A1-3.
DR PANTHER; PTHR16228; PTHR16228; 1.
DR Pfam; PF01769; MgtE; 2.
DR SUPFAM; SSF161093; SSF161093; 2.
PE 2: Evidence at transcript level;
KW Ion transport; Magnesium; Membrane; Phosphoprotein; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..573
FT /note="Solute carrier family 41 member 2"
FT /id="PRO_0000295041"
FT TOPO_DOM 1..162
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..195
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..245
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..282
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..313
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..376
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 398..406
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 428..469
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 470..490
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 491..498
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 520..543
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 565..573
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT MOD_RES 136
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BYR8"
FT MOD_RES 137
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BYR8"
SQ SEQUENCE 573 AA; 62500 MW; 4884456A64510D5F CRC64;
MTNSKGRSIT DKTSGGPSNG GGFVDWTLRL NTIQSDKFLN LLLSMVPVIY QKNQEDRHKK
ANGIWQDGLS TAVQTFSNRS EQHMEYHSFS EQSFHANNGH ASSSCSQKYD DYANYNYCDG
RETSETTAML QDEDVSSDGD EDAIVEVTPK LPKESSGIMA LQILVPFLLA GFGTVSAGMV
LDIVQHWEVF RKVTEVFILV PALLGLKGNL EMTLASRLST AVNIGKMDSP IEKWNLIIGN
LALKQVQATV VGFLAAVAAI ILGWIPEGKY YLDHSILLCS SSVATAFIAS LLQGIIMVGV
IVGSKKTGIN PDNVATPIAA SFGDLITLAI LAWISQGLYS CLETYYYISP LVGVFFLALT
PIWIIIAAKH PATRTVLHSG WEPVITAMVI SSIGGLILDT TVSDPNLVGI VVYTPVINGI
GGNLVAIQAS RISTYLHLHS IPGELPDEPK GCYYPFRTFF GPGVNNKSAQ VLLLLVIPGH
LIFLYTIHLM KSGHTSLTII FIVVYLFAAV LQVFTLLWIA DWMVHHFWRK GKDPDSFSIP
YLTALGDLLG TALLALSFHF LWLIGDRDGD VGD
