ID   S41A2_XENLA             Reviewed;         561 AA.
AC   Q6DFC0;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Solute carrier family 41 member 2;
GN   Name=slc41a2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a plasma-membrane magnesium transporter.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the SLC41A transporter family. {ECO:0000305}.
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DR   EMBL; BC076819; AAH76819.1; -; mRNA.
DR   RefSeq; NP_001086569.1; NM_001093100.1.
DR   RefSeq; XP_018106495.1; XM_018251006.1.
DR   AlphaFoldDB; Q6DFC0; -.
DR   DNASU; 446404; -.
DR   GeneID; 446404; -.
DR   KEGG; xla:446404; -.
DR   CTD; 446404; -.
DR   Xenbase; XB-GENE-955992; slc41a2.L.
DR   OMA; WMWKLGL; -.
DR   OrthoDB; 1059294at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 446404; Expressed in liver and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.357.20; -; 2.
DR   InterPro; IPR006667; SLC41_membr_dom.
DR   InterPro; IPR036739; SLC41_membr_dom_sf.
DR   InterPro; IPR045349; SLC41A1-3.
DR   PANTHER; PTHR16228; PTHR16228; 1.
DR   Pfam; PF01769; MgtE; 2.
DR   SUPFAM; SSF161093; SSF161093; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Magnesium; Membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..561
FT                   /note="Solute carrier family 41 member 2"
FT                   /id="PRO_0000295044"
FT   TOPO_DOM        1..150
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..183
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        205..233
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        255..270
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..301
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        323..333
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        355..364
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        386..394
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        395..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        416..457
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        479..487
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        488..508
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        509..531
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        532..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        553..561
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   561 AA;  60537 MW;  772B9607D75B0B21 CRC64;
     MTANTGEPYK RHSNESPVDR NINVNAIQSD KFLSLLLSMV PVVCQTGQEE RLKKVNGLTP
     IGYGFNIRTD QHLEFHNLSE PNYLGNGLHC SSLCSTNYDF DGYDYCDGIN ASETDAMLQD
     SRSSADGDKD ALVEGSKKQT KESSIAMALQ ILVPFLLAGF GTVSAGMVLD IVQHWDVFKN
     LTEVFILVPA LLGLKGNLEM TLASRLSTAV NVGKMDSPIE KWNLIIGNLA LKQVQATVVG
     FLAAVFAVIL GWIPDGKYQL DHAILLCSSS VATAFIASLL QGIIMVGVIV GSKKTGINPD
     NVATPIAASF GDLITLAILA WISQGLYNCL GSYAFVSPLV GVFFLAMTPI WIVIASKHPA
     TRTVLHSGWE PVITAMLISS IGGLILDTTV SDPNLVGIVV YTPVINGIGG NLVAIQASRI
     STYLHLYSIP GELPEDAKGC YHPCRTFCGT GVNNKSAQVL LSLVIPGHLI FLYTIYLMKS
     GHTSLTPIFV AVYLLAALLQ VFALLWIADW MVHHIWRKGK DPDSFSIPYL TALGDLLGTA
     LLAISFHILW IIGDRDGDVG D