ID   BEST6_CAEEL             Reviewed;         382 AA.
AC   Q17851; D0VWM1;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2013, sequence version 3.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Bestrophin-6;
GN   Name=best-6; ORFNames=C09B9.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
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DR   EMBL; FO080453; CCD63833.1; -; Genomic_DNA.
DR   PIR; T15468; T15468.
DR   RefSeq; NP_001255268.1; NM_001268339.1.
DR   AlphaFoldDB; Q17851; -.
DR   SMR; Q17851; -.
DR   STRING; 6239.C09B9.3.1; -.
DR   PaxDb; Q17851; -.
DR   EnsemblMetazoa; C09B9.3.1; C09B9.3.1; WBGene00015628.
DR   EnsemblMetazoa; C09B9.3.2; C09B9.3.2; WBGene00015628.
DR   GeneID; 177270; -.
DR   KEGG; cel:CELE_C09B9.3; -.
DR   UCSC; C09B9.3; c. elegans.
DR   CTD; 177270; -.
DR   WormBase; C09B9.3; CE44268; WBGene00015628; best-6.
DR   eggNOG; KOG3547; Eukaryota.
DR   GeneTree; ENSGT00940000169100; -.
DR   HOGENOM; CLU_018069_0_1_1; -.
DR   InParanoid; Q17851; -.
DR   OMA; EICSTIM; -.
DR   OrthoDB; 279144at2759; -.
DR   PhylomeDB; Q17851; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   PRO; PR:Q17851; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00015628; Expressed in adult organism and 1 other tissue.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   InterPro; IPR000615; Bestrophin.
DR   InterPro; IPR021134; Bestrophin/UPF0187.
DR   PANTHER; PTHR10736; PTHR10736; 1.
DR   Pfam; PF01062; Bestrophin; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..382
FT                   /note="Bestrophin-6"
FT                   /id="PRO_0000143127"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   382 AA;  44572 MW;  D25E83902BCD5C9D CRC64;
     MTISYTYDVA TESYFGFFKV LFRWKGSVWK LIHRELFMWL VLYYTVLAIY RTLDEERKKI
     FRSNIEHFIN FEPSILTFML SFFVTTIVQR WNNVFTNMGF IENAAYAVSS FMKNGEDVRR
     AQRTVIRYLV ASQILVMRSI SIKALRRFPN YESIVTAGFL TKEESTIIQN TDLSYDSSCV
     PIRWAIQVLR HQYRSGNFFS HSVYRATWKE VSDFETHLSR VRKVDWVPIP LAYPQVIFFA
     VRLYFVICAF AKQYFDLDDD DARYVIHYYF PIVTVFQFIC LMGWLKVAEA LLNPLGEDDD
     DFEVNFLIDS NIYTGMLIIE TSKPPPLKPD LFEDRNFGPI YPNNITDQSV GQALCGSVEN
     IKLAGKDASI EVKKNGENNP PA