S41A3_RAT
ID S41A3_RAT Reviewed; 462 AA.
AC Q3SWT5;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Solute carrier family 41 member 3;
GN Name=Slc41a3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+)
CC efflux system at the mitochondrial inner membrane.
CC {ECO:0000250|UniProtKB:Q96GZ6}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Mg(2+)(in) + 2 Na(+)(out) = Mg(2+)(out) + 2 Na(+)(in);
CC Xref=Rhea:RHEA:66616, ChEBI:CHEBI:18420, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000250|UniProtKB:Q96GZ6};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66617;
CC Evidence={ECO:0000250|UniProtKB:Q96GZ6};
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q96GZ6}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family. {ECO:0000305}.
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DR EMBL; BC104698; AAI04699.1; -; mRNA.
DR RefSeq; NP_001032569.1; NM_001037492.1.
DR RefSeq; XP_006236937.1; XM_006236875.3.
DR AlphaFoldDB; Q3SWT5; -.
DR STRING; 10116.ENSRNOP00000065688; -.
DR iPTMnet; Q3SWT5; -.
DR PhosphoSitePlus; Q3SWT5; -.
DR PaxDb; Q3SWT5; -.
DR PRIDE; Q3SWT5; -.
DR Ensembl; ENSRNOT00000073268; ENSRNOP00000065688; ENSRNOG00000045821.
DR GeneID; 641603; -.
DR KEGG; rno:641603; -.
DR CTD; 54946; -.
DR RGD; 1589573; Slc41a3.
DR eggNOG; KOG3788; Eukaryota.
DR GeneTree; ENSGT00950000183042; -.
DR HOGENOM; CLU_018207_2_0_1; -.
DR InParanoid; Q3SWT5; -.
DR OMA; FCFQGKK; -.
DR PhylomeDB; Q3SWT5; -.
DR PRO; PR:Q3SWT5; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000045821; Expressed in skeletal muscle tissue and 18 other tissues.
DR ExpressionAtlas; Q3SWT5; baseline and differential.
DR Genevisible; Q3SWT5; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0061768; F:magnesium:sodium antiporter activity; ISS:UniProtKB.
DR GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; ISS:UniProtKB.
DR Gene3D; 1.10.357.20; -; 2.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR InterPro; IPR045349; SLC41A1-3.
DR PANTHER; PTHR16228; PTHR16228; 1.
DR Pfam; PF01769; MgtE; 2.
DR SUPFAM; SSF161093; SSF161093; 2.
PE 2: Evidence at transcript level;
KW Ion transport; Magnesium; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..462
FT /note="Solute carrier family 41 member 3"
FT /id="PRO_0000295594"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 462 AA; 50526 MW; 859CBE325A6E936F CRC64;
MVVTQLSLEF RFQGKKLRGF SCELTRSPHG VLPESVLSTT CQVAIPILLS GLGMMTAGLV
MNTVQHWPVF RDVKDLLTLV PPLVGLKGNL EMTLASRLST SANTGQIDDR QERYRIISSN
LAVVQVQATV VGLLAAVASL MLGTVSHEEF DWAKVALLCT SSVITAFLAA LALGILMICI
VIGARKFGVN PDNIATPIAA SLGDLITLSI LALMSSFFYS HRDTWYLTPL VCIGFLALTP
LWIFIAKQNP PIMKILKYGW FPIILAMIIS SFGGLILSKT ISKHQFKGMA VLTPVICGVG
GNLVAIQTSR ISTFLHMWST PGVLPVQMKR FWPNPCFTFC SSEINSVSAR VLLFLVVPGH
LIFFYLICLV EGQSVTSSKI FVLLYLMAGM MQVVILLYLA EVMVRLTWHQ ALDPDNHCIP
YLTGLGDLLG TSLLALCFLL DWLLRGRANL AELVSELVSV PP
