S45A1_RAT
ID S45A1_RAT Reviewed; 751 AA.
AC Q8K4S3;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Proton-associated sugar transporter A {ECO:0000303|PubMed:12417639};
DE Short=PAST-A {ECO:0000303|PubMed:12417639};
DE AltName: Full=Solute carrier family 45 member 1;
GN Name=Slc45a1 {ECO:0000312|RGD:708502}; Synonyms=Dnb5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, TRANSPORTER
RP ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, AND SUBCELLULAR LOCATION.
RC TISSUE=Brain;
RX PubMed=12417639; DOI=10.1523/jneurosci.22-21-09160.2002;
RA Shimokawa N., Okada J., Haglund K., Dikic I., Koibuchi N., Miura M.;
RT "Past-A, a novel proton-associated sugar transporter, regulates glucose
RT homeostasis in the brain.";
RL J. Neurosci. 22:9160-9165(2002).
CC -!- FUNCTION: Proton-associated glucose transporter in the brain.
CC {ECO:0000269|PubMed:12417639}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-galactose(in) + H(+)(in) = D-galactose(out) + H(+)(out);
CC Xref=Rhea:RHEA:29019, ChEBI:CHEBI:4139, ChEBI:CHEBI:15378;
CC Evidence={ECO:0000269|PubMed:12417639};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose(out) + H(+)(out) = D-glucose(in) + H(+)(in);
CC Xref=Rhea:RHEA:69556, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378;
CC Evidence={ECO:0000269|PubMed:12417639};
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC pH dependence:
CC Optimum pH is 6.5. {ECO:0000269|PubMed:12417639};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12417639}; Multi-
CC pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in brain.
CC {ECO:0000269|PubMed:12417639}.
CC -!- SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH) cation
CC symporter transporter (TC 2.A.2) family. {ECO:0000305}.
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DR EMBL; AB075229; BAB97313.1; -; mRNA.
DR AlphaFoldDB; Q8K4S3; -.
DR STRING; 10116.ENSRNOP00000024581; -.
DR TCDB; 2.A.2.4.4; the glycoside-pentoside-hexuronide (gph):cation symporter family.
DR PaxDb; Q8K4S3; -.
DR PRIDE; Q8K4S3; -.
DR UCSC; RGD:708502; rat.
DR RGD; 708502; Slc45a1.
DR eggNOG; KOG0637; Eukaryota.
DR InParanoid; Q8K4S3; -.
DR PhylomeDB; Q8K4S3; -.
DR PRO; PR:Q8K4S3; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015517; F:galactose:proton symporter activity; IDA:UniProtKB.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; IMP:RGD.
DR GO; GO:0005356; F:glucose:proton symporter activity; IDA:UniProtKB.
DR GO; GO:0008506; F:sucrose:proton symporter activity; IBA:GO_Central.
DR GO; GO:0015757; P:galactose transmembrane transport; IDA:UniProtKB.
DR GO; GO:1904659; P:glucose transmembrane transport; IMP:UniProtKB.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Sugar transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..751
FT /note="Proton-associated sugar transporter A"
FT /id="PRO_0000122516"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 536..556
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 576..596
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 606..626
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 630..650
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 688..708
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 710..730
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 500
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8BIV7"
SQ SEQUENCE 751 AA; 81752 MW; 5C33E1C2E4A1B2EC CRC64;
MIPPAGSTPP GEALIPSVAP QDFWRSPISG YSGSVTRHIS HRANNFKRHP KRRKYIRPSP
PPPPNTPCPI ELVDFEDLHP QRSFWELLFN GCILFGIEFS YAMETAYVTP VLLQMGLPDQ
LYSLVWFISP ILGFLLQPLL GAWSDRCTSR FGRRRPFILV LAIGALLGLS LLLNGRDIGM
ALADTATNHK WGILLTVCGV VLMDFSADSA DNPSHAYMMD VCGPVDQDRG LNIHALMAGL
GGGFGYVVGG IHWDKTSFGR ALGGQLRVIY IFTAITLSVT TVFTLVSIPE RPLRPLGEKR
TAMKSPSLPL PPSPPVLLEE GAGDTLPSTT ATSLYASFSS PISPPSPLTP KYGSFISRDS
SLTGINEFAS SFGTSNIDSV LIDCFTAGHD NYLALPSSVP RQAISVSFPR APDGFYCQER
GLERREGPLT LGLDGDVLRV GSLDTSKPRA SGILKRPQTL ALPDVAGGNG PETSRRRNVT
FSQQVANILL NGVKYESELT GSSEQSEQPL SLRRLCSTIY NMPRPVRNLC VNHFLGWLSF
EGMLLFYTDF MGEVVFQGDP KAPHASEAYQ KYNSGVTMGC WGMCIYAFSA AFYSAILEKL
EECLSVRTLY FIAYLLFGLG TGLATLSRNL YVVLSLCTHY GILFSTLCTL PYSLLCDYYQ
SKKFAGSSAD GTRRGMGVDI SLLSCQYFLA QILVSLVLGP LTSAVGSANG VMYFASLVSF
LGCLYSSLCV TYEIPSADAA DEERQPLLLN V
