ID   BEST9_CAEEL             Reviewed;         399 AA.
AC   Q94175;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   02-FEB-2004, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Bestrophin homolog 9;
GN   Name=best-9; ORFNames=C43G2.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Forms chloride channels. {ECO:0000250}.
CC   -!- SUBUNIT: Forms oligomers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
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DR   EMBL; FO080265; CCD62454.1; -; Genomic_DNA.
DR   PIR; B88710; B88710.
DR   RefSeq; NP_501000.2; NM_068599.4.
DR   AlphaFoldDB; Q94175; -.
DR   SMR; Q94175; -.
DR   STRING; 6239.C43G2.4.1; -.
DR   PaxDb; Q94175; -.
DR   EnsemblMetazoa; C43G2.4.1; C43G2.4.1; WBGene00016613.
DR   EnsemblMetazoa; C43G2.4.2; C43G2.4.2; WBGene00016613.
DR   EnsemblMetazoa; C43G2.4.3; C43G2.4.3; WBGene00016613.
DR   UCSC; C43G2.4; c. elegans.
DR   WormBase; C43G2.4; CE34750; WBGene00016613; best-9.
DR   eggNOG; KOG3547; Eukaryota.
DR   HOGENOM; CLU_018069_0_1_1; -.
DR   InParanoid; Q94175; -.
DR   OMA; NNKFIAW; -.
DR   OrthoDB; 279144at2759; -.
DR   PhylomeDB; Q94175; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   PRO; PR:Q94175; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00016613; Expressed in larva and 3 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   InterPro; IPR000615; Bestrophin.
DR   InterPro; IPR021134; Bestrophin/UPF0187.
DR   PANTHER; PTHR10736; PTHR10736; 1.
DR   Pfam; PF01062; Bestrophin; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..399
FT                   /note="Bestrophin homolog 9"
FT                   /id="PRO_0000143128"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   399 AA;  47872 MW;  C3185664DF52A4A9 CRC64;
     MTISYSGNFF RLLLRWKGSI WRSVWRELFL FLFLFYFIRF SAPHFFNYTD PTDSKGYRKI
     FKVMCNEFHE YTKMIPLTFL LGFYVSNVVS RWWRQFETLR WPEDFLSILC LLLPSKESRP
     ARHQIARYLN LTSALAWRDV STKIRLRFPS LRNIIDAGLL TEKEYEKLQD INEPSPGIRW
     LTPLHWVQQL IDAEITAGRG SVNYVSVATN ELKAYRISFR RLYCHDWVCV PLVYTQVAAL
     ATYSYFFFCL FGRQDLNHDD FYSLDAFFPL FTVVQFLFFV GWFKVGQDLM RPFGLDDDDF
     ELSYILDRNI VTSFTIVDSL QDDDPPKFEE DVFWKHHNEQ QQMHQSMFLP RVPTSLKWGR
     IDLSRNAHKH PPKLHTYLEM KNQDPEEYKN RKNNKFIAW