S45A2_PIG
ID S45A2_PIG Reviewed; 532 AA.
AC Q4LE88;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=Membrane-associated transporter protein;
DE AltName: Full=Solute carrier family 45 member 2;
GN Name=SLC45A2; Synonyms=MATP;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS ARG-465 AND MET-512.
RC TISSUE=Retina;
RX PubMed=16441305; DOI=10.1111/j.1365-2052.2005.01404.x;
RA Okumura N., Hayashi T., Sekikawa H., Matsumoto T., Mikawa A., Hamasima N.,
RA Awata T.;
RT "Sequencing, mapping and nucleotide variation of porcine coat color genes
RT EDNRB, MYO5A, KITLG, SLC45A2, RAB27A, SILV and MITF.";
RL Anim. Genet. 37:80-82(2006).
CC -!- FUNCTION: Melanocyte differentiation antigen. May transport substances
CC required for melanin biosynthesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH) cation
CC symporter transporter (TC 2.A.2) family. {ECO:0000305}.
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DR EMBL; AB209955; BAE03305.1; -; mRNA.
DR AlphaFoldDB; Q4LE88; -.
DR STRING; 9823.ENSSSCP00000017818; -.
DR PaxDb; Q4LE88; -.
DR eggNOG; KOG0637; Eukaryota.
DR InParanoid; Q4LE88; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Melanin biosynthesis; Membrane; Reference proteome;
KW Sensory transduction; Transmembrane; Transmembrane helix; Vision.
FT CHAIN 1..532
FT /note="Membrane-associated transporter protein"
FT /id="PRO_0000252361"
FT TOPO_DOM 1..45
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..68
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..105
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..138
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..184
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..216
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 341..367
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 389..399
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 421..426
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 448..479
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 480..500
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 501..506
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 507..527
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 528..532
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 357
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 465
FT /note="G -> R"
FT /evidence="ECO:0000269|PubMed:16441305"
FT VARIANT 512
FT /note="T -> M"
FT /evidence="ECO:0000269|PubMed:16441305"
SQ SEQUENCE 532 AA; 58461 MW; C349467CF45606BF CRC64;
MDESSGQPDV HTYKSLAEDG PFCSVEPPKR PTGSLVMHSM AMFGREFCYA VEAAYVTPVL
LSVGLPKSLY SVVWLLSPVL GFLLQPVVGS ASDHCRARWG RRRPYILALG VMMLLGMALY
LNGDTIISAL IADPRRKPIW AISITMTGVV LFDFAADFID GPIKAYLFDV CTHQDKERGL
HYHALFTGLG GALGYLLGAI DWAHLELGRL LGTEFQVMFF FSSLVLTLCF IIHLCSIPEA
PLRDTAKDTP PRQAPQDPAS SSDRMYEYGS IEKVKNGYVN PELALQGGKT KNPPAEQTQR
TMTIKSLLRA LMSMPAHYRC LCISHLIGWT AFLSNMLFFT DFMGQIVYHG DPYSAHNSTE
FLIYQRGVEV GCWGLCINSV FSSLYSYFQK ALVPYVGLKG LYFMGYLLFG LGTGFIGLFP
NVYSTLVMCT SFGVMSSTLY TVPFNLIAMY HREEQEEQRQ QAQGGGLDSS RRGQGLDCAA
LTCMVQLAQI LVGGGLGFLV NVVGSVVVVV ITASAAALIG CCFVALFVRY ID
