S45A3_HUMAN
ID S45A3_HUMAN Reviewed; 553 AA.
AC Q96JT2; A8K2U9;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Solute carrier family 45 member 3;
DE AltName: Full=Prostate cancer-associated protein 6;
DE AltName: Full=Prostein;
GN Name=SLC45A3; Synonyms=PCANAP6, PRST;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC TISSUE=Prostate;
RX PubMed=11245466;
RA Xu J., Kalos M., Stolk J.A., Zasloff E.J., Zhang X., Houghton R.L.,
RA Filho A.M., Nolasco M., Badaro R., Reed S.G.;
RT "Identification and characterization of prostein, a novel prostate-specific
RT protein.";
RL Cancer Res. 61:1563-1568(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thalamus, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=14997204; DOI=10.1038/sj.bjc.6601642;
RA Kiessling A., Stevanovic S., Fuessel S., Weigle B., Rieger M.A., Temme A.,
RA Rieber E.P., Schmitz M.;
RT "Identification of an HLA-A(*)0201-restricted T-cell epitope derived from
RT the prostate cancer-associated protein prostein.";
RL Br. J. Cancer 90:1034-1040(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Prostate specific. Expressed in all prostatic
CC glandular cells. Expressed both in normal and cancerous prostates.
CC {ECO:0000269|PubMed:11245466, ECO:0000269|PubMed:14997204}.
CC -!- INDUCTION: Up-regulated by androgens. {ECO:0000269|PubMed:11245466}.
CC -!- MISCELLANEOUS: Marker for prostate cells. May be used, in case of
CC prostate cancers, as a target antigen for prostate carcinomas-directed
CC cytotoxic T-cell lymphocytes.
CC -!- SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH) cation
CC symporter transporter (TC 2.A.2) family. {ECO:0000305}.
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DR EMBL; AY033593; AAK54386.1; -; mRNA.
DR EMBL; AK290364; BAF83053.1; -; mRNA.
DR EMBL; AK313479; BAG36263.1; -; mRNA.
DR EMBL; CH471067; EAW91575.1; -; Genomic_DNA.
DR EMBL; BC050416; AAH50416.1; -; mRNA.
DR CCDS; CCDS1458.1; -.
DR RefSeq; NP_149093.1; NM_033102.2.
DR RefSeq; XP_005245613.1; XM_005245556.3.
DR RefSeq; XP_005245614.1; XM_005245557.4.
DR RefSeq; XP_016858127.1; XM_017002638.1.
DR AlphaFoldDB; Q96JT2; -.
DR BioGRID; 124520; 7.
DR STRING; 9606.ENSP00000356113; -.
DR TCDB; 2.A.2.4.8; the glycoside-pentoside-hexuronide (gph):cation symporter family.
DR iPTMnet; Q96JT2; -.
DR PhosphoSitePlus; Q96JT2; -.
DR BioMuta; SLC45A3; -.
DR DMDM; 46396996; -.
DR MassIVE; Q96JT2; -.
DR MaxQB; Q96JT2; -.
DR PaxDb; Q96JT2; -.
DR PeptideAtlas; Q96JT2; -.
DR PRIDE; Q96JT2; -.
DR ProteomicsDB; 77008; -.
DR Antibodypedia; 20683; 213 antibodies from 29 providers.
DR DNASU; 85414; -.
DR Ensembl; ENST00000367145.4; ENSP00000356113.3; ENSG00000158715.6.
DR GeneID; 85414; -.
DR KEGG; hsa:85414; -.
DR MANE-Select; ENST00000367145.4; ENSP00000356113.3; NM_033102.3; NP_149093.1.
DR UCSC; uc001hda.2; human.
DR CTD; 85414; -.
DR DisGeNET; 85414; -.
DR GeneCards; SLC45A3; -.
DR HGNC; HGNC:8642; SLC45A3.
DR HPA; ENSG00000158715; Tissue enriched (prostate).
DR MIM; 605097; gene.
DR neXtProt; NX_Q96JT2; -.
DR OpenTargets; ENSG00000158715; -.
DR PharmGKB; PA32981; -.
DR VEuPathDB; HostDB:ENSG00000158715; -.
DR eggNOG; KOG0637; Eukaryota.
DR GeneTree; ENSGT00950000182914; -.
DR HOGENOM; CLU_015081_2_2_1; -.
DR InParanoid; Q96JT2; -.
DR OMA; FQWYALF; -.
DR OrthoDB; 1230185at2759; -.
DR PhylomeDB; Q96JT2; -.
DR TreeFam; TF325412; -.
DR PathwayCommons; Q96JT2; -.
DR Reactome; R-HSA-189200; Cellular hexose transport.
DR BioGRID-ORCS; 85414; 15 hits in 1079 CRISPR screens.
DR ChiTaRS; SLC45A3; human.
DR GeneWiki; SLC45A3; -.
DR GenomeRNAi; 85414; -.
DR Pharos; Q96JT2; Tbio.
DR PRO; PR:Q96JT2; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96JT2; protein.
DR Bgee; ENSG00000158715; Expressed in prostate gland and 141 other tissues.
DR Genevisible; Q96JT2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0008506; F:sucrose:proton symporter activity; ISS:ParkinsonsUK-UCL.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; TAS:Reactome.
DR GO; GO:0008645; P:hexose transmembrane transport; TAS:Reactome.
DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; ISS:ParkinsonsUK-UCL.
DR GO; GO:0010907; P:positive regulation of glucose metabolic process; ISS:ParkinsonsUK-UCL.
DR GO; GO:0048713; P:regulation of oligodendrocyte differentiation; ISS:ParkinsonsUK-UCL.
DR GO; GO:0015770; P:sucrose transport; ISS:ParkinsonsUK-UCL.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..553
FT /note="Solute carrier family 45 member 3"
FT /id="PRO_0000122519"
FT TRANSMEM 19..39
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
SQ SEQUENCE 553 AA; 59323 MW; 0AFA23FBC742A667 CRC64;
MVQRLWVSRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE KFMTMVLGIG
PVLGLVCVPL LGSASDHWRG RYGRRRPFIW ALSLGILLSL FLIPRAGWLA GLLCPDPRPL
ELALLILGVG LLDFCGQVCF TPLEALLSDL FRDPDHCRQA YSVYAFMISL GGCLGYLLPA
IDWDTSALAP YLGTQEECLF GLLTLIFLTC VAATLLVAEE AALGPTEPAE GLSAPSLSPH
CCPCRARLAF RNLGALLPRL HQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL
YQGVPRAEPG TEARRHYDEG VRMGSLGLFL QCAISLVFSL VMDRLVQRFG TRAVYLASVA
AFPVAAGATC LSHSVAVVTA SAALTGFTFS ALQILPYTLA SLYHREKQVF LPKYRGDTGG
ASSEDSLMTS FLPGPKPGAP FPNGHVGAGG SGLLPPPPAL CGASACDVSV RVVVGEPTEA
RVVPGRGICL DLAILDSAFL LSQVAPSLFM GSIVQLSQSV TAYMVSAAGL GLVAIYFATQ
VVFDKSDLAK YSA
