S45A3_MOUSE
ID S45A3_MOUSE Reviewed; 553 AA.
AC Q8K0H7; Q8K252; Q8R1I0;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Solute carrier family 45 member 3;
DE AltName: Full=Prostate cancer-associated protein 6;
DE AltName: Full=Prostein;
GN Name=Slc45a3; Synonyms=Pcanap6, Prst;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, Liver, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=14561649; DOI=10.1095/biolreprod.103.021493;
RA Hsia N., Cornwall G.A.;
RT "DNA microarray analysis of region-specific gene expression in the mouse
RT epididymis.";
RL Biol. Reprod. 70:448-457(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the epididymis.
CC {ECO:0000269|PubMed:14561649}.
CC -!- SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH) cation
CC symporter transporter (TC 2.A.2) family. {ECO:0000305}.
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DR EMBL; AK035428; BAC29063.1; -; mRNA.
DR EMBL; BC024519; AAH24519.1; -; mRNA.
DR EMBL; BC031381; AAH31381.1; -; mRNA.
DR EMBL; BC034084; AAH34084.1; -; mRNA.
DR CCDS; CCDS15278.1; -.
DR RefSeq; NP_001171099.1; NM_001177628.2.
DR RefSeq; NP_666089.1; NM_145977.2.
DR RefSeq; XP_006529404.1; XM_006529341.2.
DR RefSeq; XP_006529405.1; XM_006529342.2.
DR AlphaFoldDB; Q8K0H7; -.
DR STRING; 10090.ENSMUSP00000027695; -.
DR PhosphoSitePlus; Q8K0H7; -.
DR PaxDb; Q8K0H7; -.
DR PRIDE; Q8K0H7; -.
DR ProteomicsDB; 260906; -.
DR Antibodypedia; 20683; 213 antibodies from 29 providers.
DR DNASU; 212980; -.
DR Ensembl; ENSMUST00000027695; ENSMUSP00000027695; ENSMUSG00000026435.
DR Ensembl; ENSMUST00000177943; ENSMUSP00000136190; ENSMUSG00000026435.
DR GeneID; 212980; -.
DR KEGG; mmu:212980; -.
DR UCSC; uc007cnz.2; mouse.
DR CTD; 85414; -.
DR MGI; MGI:1922082; Slc45a3.
DR VEuPathDB; HostDB:ENSMUSG00000026435; -.
DR eggNOG; KOG0637; Eukaryota.
DR GeneTree; ENSGT00950000182914; -.
DR HOGENOM; CLU_015081_2_2_1; -.
DR InParanoid; Q8K0H7; -.
DR OMA; FQWYALF; -.
DR OrthoDB; 1230185at2759; -.
DR PhylomeDB; Q8K0H7; -.
DR TreeFam; TF325412; -.
DR Reactome; R-MMU-189200; Cellular hexose transport.
DR BioGRID-ORCS; 212980; 1 hit in 74 CRISPR screens.
DR PRO; PR:Q8K0H7; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8K0H7; protein.
DR Bgee; ENSMUSG00000026435; Expressed in prostate gland ventral lobe and 179 other tissues.
DR ExpressionAtlas; Q8K0H7; baseline and differential.
DR Genevisible; Q8K0H7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008506; F:sucrose:proton symporter activity; IDA:MGI.
DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IMP:ParkinsonsUK-UCL.
DR GO; GO:0010907; P:positive regulation of glucose metabolic process; IMP:ParkinsonsUK-UCL.
DR GO; GO:0048713; P:regulation of oligodendrocyte differentiation; IMP:ParkinsonsUK-UCL.
DR GO; GO:0015770; P:sucrose transport; IDA:MGI.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..553
FT /note="Solute carrier family 45 member 3"
FT /id="PRO_0000122521"
FT TRANSMEM 19..39
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
SQ SEQUENCE 553 AA; 59742 MW; 6A474FEA630B4B13 CRC64;
MIQRLWASRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE KFMTMVLGIG
PVLGLVSVPL LGSASDQWRG RYGRRRPFIW ALSLGVLLSL FLIPRAGWLA GLLYPDTRPL
ELALLILGVG LLDFCGQVCF TPLEALLSDL FRDPDHCRQA FSVYAFMISL GGCLGYLLPA
IDWDTSVLAP YLGTQEECLF GLLTLIFLIC MAATLFVTEE AVLGPPEPAE GLLVSAVSRR
CCPCHVGLAF RNLGTLFPRL QQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL
YQGVPRAEPG TEARRHYDEG IRMGSLGLFL QCAISLVFSL VMDRLVQKFG TRSVYLASVM
TFPVAAAATC LSHSVVVVTA SAALTGFTFS ALQILPYTLA SLYHREKQVF LPKYRGDAGG
SSGEDSQTTS FLPGPKPGAL FPNGHVGSGS SGILAPPPAL CGASACDVSM RVVVGEPPEA
RVVTGRGICL DLAILDSAFL LSQVAPSLFM GSIVQLSHSV TAYMVSAAGL GLVAIYFATQ
VVFDKNDLAK YSV
