S45A4_HUMAN
ID S45A4_HUMAN Reviewed; 768 AA.
AC Q5BKX6; Q6ZRI2; Q9ULU3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Solute carrier family 45 member 4;
GN Name=SLC45A4; Synonyms=KIAA1126;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 151-768 (ISOFORMS 1/2), AND
RP VARIANT ASP-718.
RC TISSUE=Brain;
RX PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT "Characterization of cDNA clones selected by the GeneMark analysis from
RT size-fractionated cDNA libraries from human brain.";
RL DNA Res. 6:329-336(1999).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424; SER-454 AND SER-732, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5BKX6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5BKX6-2; Sequence=VSP_033540, VSP_033541;
CC Name=3;
CC IsoId=Q5BKX6-3; Sequence=VSP_033540, VSP_033541, VSP_033542;
CC -!- SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH) cation
CC symporter transporter (TC 2.A.2) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH90891.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK128212; BAC87328.1; -; mRNA.
DR EMBL; AC011676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC090891; AAH90891.1; ALT_INIT; mRNA.
DR EMBL; AB032952; BAA86440.1; -; mRNA.
DR CCDS; CCDS34948.1; -. [Q5BKX6-3]
DR CCDS; CCDS69550.1; -. [Q5BKX6-2]
DR RefSeq; NP_001073900.1; NM_001080431.2. [Q5BKX6-3]
DR RefSeq; NP_001273575.1; NM_001286646.1.
DR RefSeq; NP_001273577.1; NM_001286648.1. [Q5BKX6-2]
DR AlphaFoldDB; Q5BKX6; -.
DR BioGRID; 121448; 9.
DR IntAct; Q5BKX6; 3.
DR MINT; Q5BKX6; -.
DR STRING; 9606.ENSP00000428137; -.
DR TCDB; 2.A.2.4.7; the glycoside-pentoside-hexuronide (gph):cation symporter family.
DR iPTMnet; Q5BKX6; -.
DR PhosphoSitePlus; Q5BKX6; -.
DR BioMuta; SLC45A4; -.
DR DMDM; 189046188; -.
DR EPD; Q5BKX6; -.
DR jPOST; Q5BKX6; -.
DR MassIVE; Q5BKX6; -.
DR MaxQB; Q5BKX6; -.
DR PaxDb; Q5BKX6; -.
DR PeptideAtlas; Q5BKX6; -.
DR PRIDE; Q5BKX6; -.
DR ProteomicsDB; 62705; -. [Q5BKX6-1]
DR ProteomicsDB; 62706; -. [Q5BKX6-2]
DR ProteomicsDB; 62707; -. [Q5BKX6-3]
DR Antibodypedia; 14508; 18 antibodies from 9 providers.
DR DNASU; 57210; -.
DR Ensembl; ENST00000024061.7; ENSP00000024061.3; ENSG00000022567.10. [Q5BKX6-3]
DR Ensembl; ENST00000519067.5; ENSP00000429059.1; ENSG00000022567.10. [Q5BKX6-2]
DR GeneID; 57210; -.
DR KEGG; hsa:57210; -.
DR UCSC; uc003ywc.3; human. [Q5BKX6-1]
DR CTD; 57210; -.
DR DisGeNET; 57210; -.
DR GeneCards; SLC45A4; -.
DR HGNC; HGNC:29196; SLC45A4.
DR HPA; ENSG00000022567; Low tissue specificity.
DR MIM; 619581; gene.
DR neXtProt; NX_Q5BKX6; -.
DR OpenTargets; ENSG00000022567; -.
DR VEuPathDB; HostDB:ENSG00000022567; -.
DR eggNOG; KOG0637; Eukaryota.
DR GeneTree; ENSGT00950000182914; -.
DR InParanoid; Q5BKX6; -.
DR PhylomeDB; Q5BKX6; -.
DR TreeFam; TF325412; -.
DR PathwayCommons; Q5BKX6; -.
DR SignaLink; Q5BKX6; -.
DR BioGRID-ORCS; 57210; 12 hits in 1076 CRISPR screens.
DR ChiTaRS; SLC45A4; human.
DR GenomeRNAi; 57210; -.
DR Pharos; Q5BKX6; Tdark.
DR PRO; PR:Q5BKX6; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q5BKX6; protein.
DR Bgee; ENSG00000022567; Expressed in pancreatic ductal cell and 158 other tissues.
DR ExpressionAtlas; Q5BKX6; baseline and differential.
DR Genevisible; Q5BKX6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008506; F:sucrose:proton symporter activity; ISS:ParkinsonsUK-UCL.
DR GO; GO:0015770; P:sucrose transport; ISS:ParkinsonsUK-UCL.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR036259; MFS_trans_sf.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..768
FT /note="Solute carrier family 45 member 4"
FT /id="PRO_0000333803"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 518..538
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 560..580
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 592..612
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 614..634
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 666..686
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 695..715
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 424
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 454
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 485
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q0P5V9"
FT MOD_RES 732
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..51
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_033540"
FT VAR_SEQ 52..80
FT /note="WVMHGAVMFGREFCYAMETALVTPILLQI -> MGKASPASGLSRPKTLVSP
FT LRSNQWSLQK (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_033541"
FT VAR_SEQ 766..768
FT /note="SVV -> RLQVLTSVRSRHIGWCRSCWRVFFFMIILEKKFSFPQCGSLRRMT
FT YLLFLSELDTLCPGQPCPWAATAHQSWEEAGPGGLGRRQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033542"
FT VARIANT 277
FT /note="P -> L (in dbSNP:rs753778)"
FT /id="VAR_043164"
FT VARIANT 718
FT /note="N -> D (in dbSNP:rs3739238)"
FT /evidence="ECO:0000269|PubMed:10574461"
FT /id="VAR_043165"
FT CONFLICT Q5BKX6-3:787
FT /note="E -> K (in Ref. 1; BAC87328)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 768 AA; 83878 MW; 8FAC1B4D0B918363 CRC64;
MKMAPQNADP ESMQVQELSV PLPDPQKAGG AEAENCETIS EGSIDRIPMR LWVMHGAVMF
GREFCYAMET ALVTPILLQI GLPEQYYSLT WFLSPILGLI FTPLIGSASD RCTLSWGRRR
PFILALCVGV LFGVALFLNG SAIGLALGDV PNRQPIGIVL TVLGVVVLDF SADATEGPIR
AYLLDVVDSE EQDMALNIHA FSAGLGGAIG YVLGGLDWTQ TFLGSWFRTQ NQVLFFFAAI
IFTVSVALHL FSIDEEQYSP QQERSAEEPG ALDGGEPHGV PAFPDEVQSE HELALDYPDV
DIMRSKSDSA LHVPDTALDL EPELLFLHDI EPSIFHDASY PATPRSTSQE LAKTKLPRLA
TFLKEAAKED ETLLDNHLNE AKVPNGSGSP TKDALGGYTR VDTKPSATSS SMRRRRHAFR
RQASSTFSYY GKLGSHCYRY RRANAVVLIK PSRSMSDLYD MQKRQRQHRH RNQSGATTSS
GDTESEEGEG ETTVRLLWLS MLKMPRELMR LCLCHLLTWF SVIAEAVFYT DFMGQVIFEG
DPKAPSNSTA WQAYNAGVKM GCWGLVIYAA TGAICSALLQ KYLDNYDLSV RVIYVLGTLG
FSVGTAVMAM FPNVYVAMVT ISTMGIVSMS ISYCPYALLG QYHDIKQYIH HSPGNSKRGF
GIDCAILSCQ VYISQILVAS ALGGVVDAVG TVRVIPMVAS VGSFLGFLTA TFLVIYPNVS
EEAKEEQKGL SSPLAGEGRA GGNSEKPTVL KLTRKEGLQG PVETESVV
