S45A4_MOUSE
ID S45A4_MOUSE Reviewed; 785 AA.
AC Q0P5V9; Q3TCG5; Q3V0B8; Q69ZR4; Q6PDG3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Solute carrier family 45 member 4;
GN Name=Slc45a4; Synonyms=Kiaa1126;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 74-785 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 312-785 (ISOFORM 1/3).
RC TISSUE=Brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-472 AND SER-502, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q0P5V9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0P5V9-2; Sequence=VSP_033544;
CC Name=3;
CC IsoId=Q0P5V9-3; Sequence=VSP_033543;
CC -!- SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH) cation
CC symporter transporter (TC 2.A.2) family. {ECO:0000305}.
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DR EMBL; AK133269; BAE21586.1; -; mRNA.
DR EMBL; AK170738; BAE41991.1; -; mRNA.
DR EMBL; BC056501; AAH56501.1; -; mRNA.
DR EMBL; BC058722; AAH58722.1; -; mRNA.
DR EMBL; AK173104; BAD32382.1; -; mRNA.
DR CCDS; CCDS27517.1; -. [Q0P5V9-1]
DR CCDS; CCDS49632.1; -. [Q0P5V9-3]
DR RefSeq; NP_001028391.2; NM_001033219.3. [Q0P5V9-1]
DR RefSeq; NP_001161727.1; NM_001168255.1. [Q0P5V9-3]
DR RefSeq; XP_011243703.1; XM_011245401.1. [Q0P5V9-1]
DR RefSeq; XP_011243704.1; XM_011245402.2.
DR RefSeq; XP_017171852.1; XM_017316363.1. [Q0P5V9-1]
DR RefSeq; XP_017171853.1; XM_017316364.1. [Q0P5V9-1]
DR AlphaFoldDB; Q0P5V9; -.
DR STRING; 10090.ENSMUSP00000121775; -.
DR iPTMnet; Q0P5V9; -.
DR PhosphoSitePlus; Q0P5V9; -.
DR MaxQB; Q0P5V9; -.
DR PaxDb; Q0P5V9; -.
DR PRIDE; Q0P5V9; -.
DR ProteomicsDB; 260790; -. [Q0P5V9-1]
DR ProteomicsDB; 260791; -. [Q0P5V9-2]
DR ProteomicsDB; 260792; -. [Q0P5V9-3]
DR Antibodypedia; 14508; 18 antibodies from 9 providers.
DR DNASU; 106068; -.
DR Ensembl; ENSMUST00000054266; ENSMUSP00000054651; ENSMUSG00000079020. [Q0P5V9-2]
DR Ensembl; ENSMUST00000076224; ENSMUSP00000075577; ENSMUSG00000079020. [Q0P5V9-1]
DR Ensembl; ENSMUST00000132607; ENSMUSP00000115827; ENSMUSG00000079020. [Q0P5V9-3]
DR Ensembl; ENSMUST00000151288; ENSMUSP00000121775; ENSMUSG00000079020. [Q0P5V9-1]
DR GeneID; 106068; -.
DR KEGG; mmu:106068; -.
DR UCSC; uc007wcf.2; mouse. [Q0P5V9-1]
DR UCSC; uc007wcg.2; mouse. [Q0P5V9-2]
DR CTD; 57210; -.
DR MGI; MGI:2146236; Slc45a4.
DR VEuPathDB; HostDB:ENSMUSG00000079020; -.
DR eggNOG; KOG0637; Eukaryota.
DR GeneTree; ENSGT00950000182914; -.
DR InParanoid; Q0P5V9; -.
DR OMA; DHLSPYH; -.
DR OrthoDB; 1230185at2759; -.
DR PhylomeDB; Q0P5V9; -.
DR TreeFam; TF325412; -.
DR BioGRID-ORCS; 106068; 5 hits in 74 CRISPR screens.
DR ChiTaRS; Slc45a4; mouse.
DR PRO; PR:Q0P5V9; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q0P5V9; protein.
DR Bgee; ENSMUSG00000079020; Expressed in placenta labyrinth and 219 other tissues.
DR ExpressionAtlas; Q0P5V9; baseline and differential.
DR Genevisible; Q0P5V9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008506; F:sucrose:proton symporter activity; IDA:MGI.
DR GO; GO:0015770; P:sucrose transport; IDA:MGI.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR036259; MFS_trans_sf.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..785
FT /note="Solute carrier family 45 member 4"
FT /id="PRO_0000333804"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 525..545
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 577..597
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 609..629
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 631..651
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 683..703
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 709..729
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 442
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5BKX6"
FT MOD_RES 472
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 502
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 749
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5BKX6"
FT VAR_SEQ 1..194
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033543"
FT VAR_SEQ 204
FT /note="A -> AGKAPLQAP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033544"
FT CONFLICT 174
FT /note="D -> Y (in Ref. 1; BAE21586)"
FT /evidence="ECO:0000305"
FT CONFLICT 365
FT /note="S -> G (in Ref. 1; BAE41991)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 785 AA; 85765 MW; EF87F734B39F5411 CRC64;
MKMAPQNADS ESMQVQELPV PLPDPQKPRD PEAETQEETT SEGSIDRIPT RLWVMHGAVM
FGREFCYAME TALVTPILLQ IGLPEKYYSL TWFLSPVLGL IFTPLIGSAS DRCTLSWGRR
RPFILALCVG VLIGVALFLN GSAIGLALGD VPSRQPIGIV LTVLGVVVLD FSADATEGPI
RAYLLDVVDS EEQDMALNIH AFSAGLGGAI GYVLGGLDWT QTFLGDWFQT QNQVLFFFAA
VIFSVSVALH LFSIEEEQYS PQQDRGPEDP TLPGTSVQPG APAPASRLSS LGGGMQDGSP
PFPDEVQSEH ELSLDYLDVD IVRSKSDSVL HMADATLDME PQLLFLHDIE PSIFQDASYP
STPQSTSQEL LRAKLPRLST FLRESTKEDD TLLDNHLNEA KVPNGRGSPP INSLSRSKVD
LKPSVTSGSM RRRRHMFHRQ ASSTFSYYGK IGSHCYRYRR ANAVVLIKPS RSMSDLYDLQ
QRQRSRHRNQ SGATASSGDT ESEEGETETT VRLLWLSMLK MPKELMWLCL CHLLTWFSVI
AEAVFYTDFM GQVIFKGNPQ APSNSTKWHA YNAGVKMGCW GLVIYAATGA ICSALLQKYL
DNYDLSIRII YMLGTLGFSV GTAVMAMFPN VYVAMVTIST MGVVSMSISY CPYALLGHYH
DIKEYVHHSP GNSKRGFGID CAILSCQVYI SQILVASALG GVVDAVNSIV VIPIVASVGS
FLGFLTATFL VIYPEVSEEP KEEQKGLSSG PAGEGEGGAG SEKPTVLKLS RKGGLRGLVE
TESMV
