ID   S46A3_BOVIN             Reviewed;         461 AA.
AC   A5D7V7;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Solute carrier family 46 member 3;
DE   Flags: Precursor;
GN   Name=SLC46A3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. SLC46A
CC       family. {ECO:0000305}.
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DR   EMBL; BC140697; AAI40698.1; -; mRNA.
DR   RefSeq; NP_001096773.1; NM_001103303.2.
DR   AlphaFoldDB; A5D7V7; -.
DR   SMR; A5D7V7; -.
DR   STRING; 9913.ENSBTAP00000011448; -.
DR   PaxDb; A5D7V7; -.
DR   GeneID; 781117; -.
DR   KEGG; bta:781117; -.
DR   CTD; 283537; -.
DR   eggNOG; KOG2816; Eukaryota.
DR   InParanoid; A5D7V7; -.
DR   OrthoDB; 763423at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:1905103; C:integral component of lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   GO; GO:0034486; P:vacuolar transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..461
FT                   /note="Solute carrier family 46 member 3"
FT                   /id="PRO_0000307252"
FT   TOPO_DOM        26..70
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        92..101
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        125..133
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..170
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        192..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..261
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        283..294
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        316..324
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        346..347
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        369..382
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        404..415
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        416..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        437..461
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        38
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   461 AA;  51303 MW;  B9500CB81C503A5F CRC64;
     MKIPFVEPVI CLSVFAVTLN SPLTTQYVYR RIWEETGNYS IALESNTSEC AKNKSSPIFA
     FQEEVQKKVS LFNLEMDISG LIPGLVSTFV FLSHSDHGGR KFPLILSSVG ALANSAWLCL
     LSYFALPIQL LIASTFIGAL FGNYTTFLGA SFAYIVDQCK EKKQRTIRIA IIDFLFGVVS
     GLTGLSSGYF IRGLGFVWSF LIVTVALFVN LIYILLFLED SMKESSSQNI SVSWTETFKN
     LFHRTYMLFK NASGEQQSLC CLLLFTMITY FFVTIGVSPI FVLYELDSPL CWDEVLIGYG
     SALGSVTFFS SFLGIWLFSY CMEDIHMAFI GTFTTMVGMA MTAFARTTLM MFLVRLPFLF
     TVMPLSVLRS MISKVVHSTE QGTMFACLAF LETLGGITAV STFNGIYSAT VAWCKGFVFL
     LSAVLLLIPA ISLCVIKYVS RNTGSYVLLI QEESSEDTSD R