S46A3_CHICK
ID S46A3_CHICK Reviewed; 464 AA.
AC Q5F4B8;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Solute carrier family 46 member 3;
DE Flags: Precursor;
GN Name=SLC46A3; ORFNames=RCJMB04_1c21;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. SLC46A
CC family. {ECO:0000305}.
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DR EMBL; AJ851382; CAH65016.1; -; mRNA.
DR RefSeq; NP_001025999.1; NM_001030828.1.
DR AlphaFoldDB; Q5F4B8; -.
DR SMR; Q5F4B8; -.
DR STRING; 9031.ENSGALP00000027554; -.
DR PaxDb; Q5F4B8; -.
DR GeneID; 418924; -.
DR KEGG; gga:418924; -.
DR CTD; 283537; -.
DR VEuPathDB; HostDB:geneid_418924; -.
DR eggNOG; KOG2816; Eukaryota.
DR InParanoid; Q5F4B8; -.
DR OrthoDB; 763423at2759; -.
DR PhylomeDB; Q5F4B8; -.
DR PRO; PR:Q5F4B8; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:1905103; C:integral component of lysosomal membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR GO; GO:0034486; P:vacuolar transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..464
FT /note="Solute carrier family 46 member 3"
FT /id="PRO_0000307257"
FT TOPO_DOM 27..71
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..130
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..171
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..296
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 348..349
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 371..384
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 406..418
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 440..464
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 464 AA; 51398 MW; 9C2066595AB829A3 CRC64;
MRKVLLVEPV IFIYIFASSL TSPVVQQFIY RKLWEEEYNS TAISSDNSSH CERNKSSPTY
VMEKAIQEKT SFFNMQLDLT GAVPSLIVAF IIVANGDHQG RKKSLVLPSI GALIADIFLT
IVSYFSWPTS VLFLATFISG LFGSMATFLG GGFAYIADQC HDEKQKTTRI AVIDLIFGVV
SGLAGLSSGY FLREMGFTWT FATASLLHVV NIIYITFFLQ DTVHISEFQQ QAPLSYKEHL
KETFSGVYML FKTAPSKKRI LIIVLLFIFM TYLFTMFGGS SLFTLYELDE PLCWTEVYIG
YGAAAFTSIS LTSFLGVYLF SKCLKDIYIV FIGIFSYIGG IVMAAFAKTT LLMFLVRVPS
LFSIMPIPVL RSMLSKVVLP SEQGAVFACI ACLEVLTGTI SLSVFNVIYA ATVAWFSGFS
FLLSASLCLI PLGVLCWLLC TSWNGEDLAL LVPEEVSSID SVDS
