S46A3_HUMAN
ID S46A3_HUMAN Reviewed; 461 AA.
AC Q7Z3Q1; Q3ZCV8; Q6NUK5; Q6P9B3; Q6ZVG5; Q96QA1;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Solute carrier family 46 member 3;
DE Flags: Precursor;
GN Name=SLC46A3; ORFNames=FKSG16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Wang Y.-G., Gong L.;
RT "Cloning of FKSG16, a novel gene located on chromosome 13.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Endometrial adenocarcinoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q7Z3Q1-2; P11912: CD79A; NbExp=3; IntAct=EBI-18074862, EBI-7797864;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q7Z3Q1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z3Q1-2; Sequence=VSP_028649;
CC Name=3;
CC IsoId=Q7Z3Q1-3; Sequence=VSP_028648;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. SLC46A
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC85896.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF315594; AAL18405.1; -; mRNA.
DR EMBL; AK124604; BAC85896.1; ALT_FRAME; mRNA.
DR EMBL; BX537565; CAD97783.1; -; mRNA.
DR EMBL; AL359454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471075; EAX08436.1; -; Genomic_DNA.
DR EMBL; CH471075; EAX08438.1; -; Genomic_DNA.
DR EMBL; BC036662; AAH36662.1; -; mRNA.
DR EMBL; BC060850; AAH60850.1; -; mRNA.
DR EMBL; BC068556; AAH68556.1; -; mRNA.
DR CCDS; CCDS45021.1; -. [Q7Z3Q1-2]
DR CCDS; CCDS9332.1; -. [Q7Z3Q1-1]
DR RefSeq; NP_001129391.1; NM_001135919.1. [Q7Z3Q1-2]
DR RefSeq; NP_001334889.1; NM_001347960.1. [Q7Z3Q1-1]
DR RefSeq; NP_861450.1; NM_181785.3. [Q7Z3Q1-1]
DR RefSeq; XP_005266418.1; XM_005266361.2. [Q7Z3Q1-2]
DR AlphaFoldDB; Q7Z3Q1; -.
DR SMR; Q7Z3Q1; -.
DR BioGRID; 129597; 5.
DR IntAct; Q7Z3Q1; 2.
DR MINT; Q7Z3Q1; -.
DR STRING; 9606.ENSP00000370192; -.
DR TCDB; 2.A.1.50.3; the major facilitator superfamily (mfs).
DR GlyGen; Q7Z3Q1; 3 sites.
DR iPTMnet; Q7Z3Q1; -.
DR PhosphoSitePlus; Q7Z3Q1; -.
DR BioMuta; SLC46A3; -.
DR DMDM; 74723295; -.
DR EPD; Q7Z3Q1; -.
DR jPOST; Q7Z3Q1; -.
DR MassIVE; Q7Z3Q1; -.
DR MaxQB; Q7Z3Q1; -.
DR PaxDb; Q7Z3Q1; -.
DR PeptideAtlas; Q7Z3Q1; -.
DR PRIDE; Q7Z3Q1; -.
DR ProteomicsDB; 69070; -. [Q7Z3Q1-1]
DR ProteomicsDB; 69071; -. [Q7Z3Q1-2]
DR ProteomicsDB; 69072; -. [Q7Z3Q1-3]
DR Antibodypedia; 7527; 62 antibodies from 17 providers.
DR DNASU; 283537; -.
DR Ensembl; ENST00000266943.11; ENSP00000266943.7; ENSG00000139508.15. [Q7Z3Q1-1]
DR Ensembl; ENST00000380814.4; ENSP00000370192.4; ENSG00000139508.15. [Q7Z3Q1-2]
DR GeneID; 283537; -.
DR KEGG; hsa:283537; -.
DR MANE-Select; ENST00000266943.11; ENSP00000266943.7; NM_181785.4; NP_861450.1.
DR UCSC; uc001ush.4; human. [Q7Z3Q1-1]
DR CTD; 283537; -.
DR DisGeNET; 283537; -.
DR GeneCards; SLC46A3; -.
DR HGNC; HGNC:27501; SLC46A3.
DR HPA; ENSG00000139508; Tissue enhanced (intestine, liver).
DR neXtProt; NX_Q7Z3Q1; -.
DR OpenTargets; ENSG00000139508; -.
DR PharmGKB; PA162403791; -.
DR VEuPathDB; HostDB:ENSG00000139508; -.
DR eggNOG; KOG2816; Eukaryota.
DR GeneTree; ENSGT00950000183096; -.
DR HOGENOM; CLU_028365_1_1_1; -.
DR InParanoid; Q7Z3Q1; -.
DR OMA; YCMEDIY; -.
DR OrthoDB; 763423at2759; -.
DR PhylomeDB; Q7Z3Q1; -.
DR TreeFam; TF315701; -.
DR PathwayCommons; Q7Z3Q1; -.
DR SignaLink; Q7Z3Q1; -.
DR BioGRID-ORCS; 283537; 9 hits in 1069 CRISPR screens.
DR ChiTaRS; SLC46A3; human.
DR GenomeRNAi; 283537; -.
DR Pharos; Q7Z3Q1; Tbio.
DR PRO; PR:Q7Z3Q1; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q7Z3Q1; protein.
DR Bgee; ENSG00000139508; Expressed in ileal mucosa and 165 other tissues.
DR ExpressionAtlas; Q7Z3Q1; baseline and differential.
DR Genevisible; Q7Z3Q1; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:1905103; C:integral component of lysosomal membrane; IMP:FlyBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IMP:FlyBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR GO; GO:0034486; P:vacuolar transmembrane transport; IMP:FlyBase.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..461
FT /note="Solute carrier family 46 member 3"
FT /id="PRO_0000307253"
FT TOPO_DOM 26..73
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..101
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..133
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..294
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 346..347
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..382
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 404..415
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 437..461
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..75
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028648"
FT VAR_SEQ 461
FT /note="R -> RAC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_028649"
FT CONFLICT 109
FT /note="V -> I (in Ref. 6; AAH68556)"
FT /evidence="ECO:0000305"
FT CONFLICT 126
FT /note="F -> L (in Ref. 1; AAL18405)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="F -> I (in Ref. 1; AAL18405)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="C -> F (in Ref. 6; AAH36662)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 461 AA; 51519 MW; CF1227F889055DE5 CRC64;
MKILFVEPAI FLSAFAMTLT GPLTTQYVYR RIWEETGNYT FSSDSNISEC EKNKSSPIFA
FQEEVQKKVS RFNLQMDISG LIPGLVSTFI LLSISDHYGR KFPMILSSVG ALATSVWLCL
LCYFAFPFQL LIASTFIGAF CGNYTTFWGA CFAYIVDQCK EHKQKTIRIA IIDFLLGLVT
GLTGLSSGYF IRELGFEWSF LIIAVSLAVN LIYILFFLGD PVKECSSQNV TMSCSEGFKN
LFYRTYMLFK NASGKRRFLL CLLLFTVITY FFVVIGIAPI FILYELDSPL CWNEVFIGYG
SALGSASFLT SFLGIWLFSY CMEDIHMAFI GIFTTMTGMA MTAFASTTLM MFLARVPFLF
TIVPFSVLRS MLSKVVRSTE QGTLFACIAF LETLGGVTAV STFNGIYSAT VAWYPGFTFL
LSAGLLLLPA ISLCVVKCTS WNEGSYELLI QEESSEDASD R
