ID   S46A3_PONAB             Reviewed;         463 AA.
AC   Q5RBM3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Solute carrier family 46 member 3;
DE   Flags: Precursor;
GN   Name=SLC46A3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. SLC46A
CC       family. {ECO:0000305}.
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DR   EMBL; CR858615; CAH90837.1; -; mRNA.
DR   RefSeq; NP_001125478.1; NM_001132006.1.
DR   AlphaFoldDB; Q5RBM3; -.
DR   SMR; Q5RBM3; -.
DR   STRING; 9601.ENSPPYP00000005976; -.
DR   Ensembl; ENSPPYT00000006211; ENSPPYP00000005976; ENSPPYG00000005248.
DR   GeneID; 100172387; -.
DR   KEGG; pon:100172387; -.
DR   CTD; 283537; -.
DR   eggNOG; KOG2816; Eukaryota.
DR   GeneTree; ENSGT00950000183096; -.
DR   HOGENOM; CLU_028365_1_1_1; -.
DR   InParanoid; Q5RBM3; -.
DR   OMA; IKQMVCG; -.
DR   OrthoDB; 763423at2759; -.
DR   TreeFam; TF315701; -.
DR   Proteomes; UP000001595; Chromosome 13.
DR   GO; GO:1905103; C:integral component of lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0034486; P:vacuolar transmembrane transport; IEA:Ensembl.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..463
FT                   /note="Solute carrier family 46 member 3"
FT                   /id="PRO_0000307255"
FT   TOPO_DOM        21..73
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        95..101
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        125..133
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..170
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        192..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..261
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        283..294
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        316..324
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        346..347
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        369..382
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        404..415
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        416..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        437..463
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        38
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   463 AA;  51652 MW;  9F33164F170ADBAD CRC64;
     MKILFVEPAI FLSAFAMTLT SPLTTQYVYR RIWEETGNYT FSSDSNISEC EKNKSSPIFA
     FQEEVQKKVS RFNLQMDISG LIPGLVSTFI LLSISDHYGR KFPMILSSVG ALATSVWLCL
     LCYFAFPFQL LIASTFIGAF CGNYTTFWGA CFAYIVDQCK EHKQKTIRIA VIDFLLGLVT
     GLTGLSSGYF IRELGFGWSF LIIAASLAVN LIYILFFLGD PVKECSSQNV TMSCSEGFKN
     LFYRTYMLFK NASGKRRFLL CLLLFTTITY FFVVIGIAPI FILYELDSPL CWNEVFIGYG
     SALGSASFLT SFLGIWLFSY CMEDIHMAFI GIFTTMTGMV MTAFASTTLM MFLARVPFLF
     TIVPFSVLRS MLSKVVRSTE QGILFACIAF LETLGGVTAV STFNGIYSAT VAWYPGFTFL
     LSAGLLLLPA ISLCVVKCTS WNEGSYELLI QEESSEDASD RAC