ID   S46A3_RAT               Reviewed;         461 AA.
AC   Q5BK75;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Solute carrier family 46 member 3;
DE   Flags: Precursor;
GN   Name=Slc46a3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. SLC46A
CC       family. {ECO:0000305}.
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DR   EMBL; BC091179; AAH91179.1; -; mRNA.
DR   RefSeq; NP_001020139.1; NM_001024968.1.
DR   RefSeq; XP_006248895.1; XM_006248833.3.
DR   AlphaFoldDB; Q5BK75; -.
DR   SMR; Q5BK75; -.
DR   STRING; 10116.ENSRNOP00000001243; -.
DR   GlyGen; Q5BK75; 3 sites.
DR   PaxDb; Q5BK75; -.
DR   Ensembl; ENSRNOT00000001243; ENSRNOP00000001243; ENSRNOG00000000937.
DR   GeneID; 288454; -.
DR   KEGG; rno:288454; -.
DR   UCSC; RGD:1307594; rat.
DR   CTD; 283537; -.
DR   RGD; 1307594; Slc46a3.
DR   eggNOG; KOG2816; Eukaryota.
DR   GeneTree; ENSGT00950000183096; -.
DR   HOGENOM; CLU_028365_1_1_1; -.
DR   InParanoid; Q5BK75; -.
DR   OMA; YCMEDIY; -.
DR   OrthoDB; 763423at2759; -.
DR   PhylomeDB; Q5BK75; -.
DR   TreeFam; TF315701; -.
DR   PRO; PR:Q5BK75; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000000937; Expressed in liver and 19 other tissues.
DR   Genevisible; Q5BK75; RN.
DR   GO; GO:1905103; C:integral component of lysosomal membrane; ISO:RGD.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; ISO:RGD.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   GO; GO:0034486; P:vacuolar transmembrane transport; ISO:RGD.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..461
FT                   /note="Solute carrier family 46 member 3"
FT                   /id="PRO_0000307256"
FT   TOPO_DOM        26..70
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        92..103
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        125..135
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..170
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        192..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..260
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        282..301
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        323..324
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        346..347
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        369..381
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        403..415
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        416..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        437..461
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        38
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   461 AA;  51527 MW;  CB7DCE21883D0656 CRC64;
     MKISFIEPAI LLYAFAMTLT IPLTAQYVYR RIWEETGNYT FTSSSNVSEC EQNKSSSTFA
     FQEEVQKKAS LFSLQVEISG LIPGLVSTFM LLSSSDNHGR KLPMVLSSLG SLGTNLWLCA
     MSYFDLPLQL LVASTFIGAL FGNYTTFWGA CFAYIVDQEK EYKHRIIRIA VLDFMLGVVT
     GLTGLSSGYF IRELGFAWSY FIIAVVVLVN LAYILFFLSD PIKESSSQIV TMSCSESLKD
     LFYRTYMLFK NGSCKRRSLL CLLIFTLVVY FFVVFGITPV FTLYELGPPL CWNEVYIGYG
     SALGSLSFLS SFLGIWLFSY CLKDIHIAYV GIFTTMVGMM LTAFTRTTLM MFLVRISFFF
     TIMPLSILRS MLSKVVHSTE QGVLFACIAF LETLGGVTST SAYNGIYSAT VAWYPGFVFL
     LSAGLLVLPA VSLCMVKCIG WEEGSYTLLI HDEPSEHTSD S