S47A1_DANRE
ID S47A1_DANRE Reviewed; 590 AA.
AC A1L1P9;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Multidrug and toxin extrusion protein 1;
DE Short=MATE-1;
DE AltName: Full=Solute carrier family 47 member 1;
GN Name=slc47a1; Synonyms=mate1; ORFNames=zgc:158231;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Solute transporter for tetraethylammonium (TEA), cimetidine,
CC metformin, guanidine, N-methylnicotinamide (NMN) and also the
CC zwitterionic cephalosporin cephalexin. Responsible for the secretion of
CC cationic drugs across the brush border membranes (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; BC129166; AAI29167.1; -; mRNA.
DR RefSeq; NP_001073648.1; NM_001080179.1.
DR AlphaFoldDB; A1L1P9; -.
DR SMR; A1L1P9; -.
DR STRING; 7955.ENSDARP00000078672; -.
DR PaxDb; A1L1P9; -.
DR PeptideAtlas; A1L1P9; -.
DR Ensembl; ENSDART00000084237; ENSDARP00000078672; ENSDARG00000060051.
DR GeneID; 560024; -.
DR KEGG; dre:560024; -.
DR CTD; 560024; -.
DR ZFIN; ZDB-GENE-070112-1472; slc47a2.1.
DR eggNOG; KOG1347; Eukaryota.
DR GeneTree; ENSGT00940000163234; -.
DR HOGENOM; CLU_012893_1_3_1; -.
DR InParanoid; A1L1P9; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; A1L1P9; -.
DR TreeFam; TF324441; -.
DR Reactome; R-DRE-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR PRO; PR:A1L1P9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 21.
DR Bgee; ENSDARG00000060051; Expressed in mesonephros and 13 other tissues.
DR ExpressionAtlas; A1L1P9; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..590
FT /note="Multidrug and toxin extrusion protein 1"
FT /id="PRO_0000312850"
FT TOPO_DOM 1..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..88
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..167
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..199
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..231
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..313
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..351
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 373..395
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 417..430
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 452
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 474..565
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 566..586
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 587..590
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 590 AA; 63759 MW; 06362BFF041A6CB1 CRC64;
MDSITSYNVT QMNGDTKQEK CDDVLSTSST QKFCGGCRKK LRSLLPVNYK TEIVELLKLA
GPVFISQLMI FLISFVSTVF CGHLGKTELA GVALAIAVIN VTGISIGSGL ASACDTLISQ
TFGSNNLKRV GVILQRGILI LLLACFPCWA LLINTEPILL AVRQSPNVAS LSQLYVKIFM
PALPAAFMYQ LQGRYLQNQG IIWPQVITGA AGNILNALIN YVFLHLLELG VAGSAAANTI
SQYSLAVFLY VYIRWKNLHK ATWDGWSRDC LQEWGAFIRL ALPSMLMLCV EWWTYEIGGF
LAGLISETEL GAQSVVYELA TIAYMFPLGF AVAASVRVGN ALGAGNTERA KLSAKVALVC
GVLVSCVVAT LIGCTKDVIA YIFTTEEEIV SRVSQVMIMY GFFHLFDAIA GITGGIVRGA
GKQLLGALCN IVGYYFVGFP TGVSLMFALS MGIIGLWIGF FGCVFLQSLF FIILIYKLDW
KKATQEALIR AGVQLTETKD ESFGLENKGC TEEAAKESQI TEEGLTDANT DLEGLSKGGE
GISEAGAKTT VGAVLTTKQL IVRRGLAVLL MVLILAGGIV LNEMLVRYLR
