S47A2_HUMAN
ID S47A2_HUMAN Reviewed; 602 AA.
AC Q86VL8; A0JBX9; A0P8Z7; Q63HJ9; Q8IV44; Q96NA1;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Multidrug and toxin extrusion protein 2;
DE Short=MATE-2;
DE Short=hMATE-2;
DE AltName: Full=Kidney-specific H(+)/organic cation antiporter;
DE AltName: Full=Solute carrier family 47 member 2;
GN Name=SLC47A2; Synonyms=MATE2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 6), TISSUE SPECIFICITY,
RP FUNCTION, AND BIOPHYSICOCHEMICAL PROPERTIES.
RC TISSUE=Brain, and Kidney;
RX PubMed=16807400; DOI=10.1681/asn.2006030205;
RA Masuda S., Terada T., Yonezawa A., Tanihara Y., Kishimoto K., Katsura T.,
RA Ogawa O., Inui K.;
RT "Identification and functional characterization of a new human kidney-
RT specific H+/organic cation antiporter, kidney-specific multidrug and toxin
RT extrusion 2.";
RL J. Am. Soc. Nephrol. 17:2127-2135(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Small intestine;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP FUNCTION.
RX PubMed=16996621; DOI=10.1016/j.tips.2006.09.001;
RA Omote H., Hiasa M., Matsumoto T., Otsuka M., Moriyama Y.;
RT "The MATE proteins as fundamental transporters of metabolic and xenobiotic
RT organic cations.";
RL Trends Pharmacol. Sci. 27:587-593(2006).
RN [7]
RP FUNCTION, AND BIOPHYSICOCHEMICAL PROPERTIES.
RX PubMed=17509534; DOI=10.1016/j.bcp.2007.04.010;
RA Tanihara Y., Masuda S., Sato T., Katsura T., Ogawa O., Inui K.;
RT "Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin
RT extrusions/H(+)-organic cation antiporters.";
RL Biochem. Pharmacol. 74:359-371(2007).
CC -!- FUNCTION: Solute transporter for tetraethylammonium (TEA), 1-methyl-4-
CC phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin,
CC creatinine, guanidine, procainamide, topotecan, estrone sulfate,
CC acyclovir, and ganciclovir. Responsible for the secretion of cationic
CC drugs across the brush border membranes. {ECO:0000269|PubMed:16807400,
CC ECO:0000269|PubMed:16996621, ECO:0000269|PubMed:17509534}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Kinetic parameters:
CC KM=0.76 mM for TEA {ECO:0000269|PubMed:16807400,
CC ECO:0000269|PubMed:17509534};
CC KM=0.11 mM for MPP {ECO:0000269|PubMed:16807400,
CC ECO:0000269|PubMed:17509534};
CC KM=0.12 mM for cimetidine {ECO:0000269|PubMed:16807400,
CC ECO:0000269|PubMed:17509534};
CC KM=1.98 mM for metformin {ECO:0000269|PubMed:16807400,
CC ECO:0000269|PubMed:17509534};
CC KM=4.2 mM for guanidine {ECO:0000269|PubMed:16807400,
CC ECO:0000269|PubMed:17509534};
CC KM=1.58 mM for procainamide {ECO:0000269|PubMed:16807400,
CC ECO:0000269|PubMed:17509534};
CC KM=0.06 mM for topotecan {ECO:0000269|PubMed:16807400,
CC ECO:0000269|PubMed:17509534};
CC KM=0.85 mM for estrone sulfate {ECO:0000269|PubMed:16807400,
CC ECO:0000269|PubMed:17509534};
CC KM=4.32 mM for acyclovir {ECO:0000269|PubMed:16807400,
CC ECO:0000269|PubMed:17509534};
CC KM=4.28 mM for ganciclovir {ECO:0000269|PubMed:16807400,
CC ECO:0000269|PubMed:17509534};
CC Vmax=0.88 nmol/min/mg enzyme toward TEA {ECO:0000269|PubMed:16807400,
CC ECO:0000269|PubMed:17509534};
CC Vmax=0.575 nmol/min/mg enzyme toward MPP
CC {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534};
CC Vmax=0.115 nmol/min/mg enzyme toward cimetidine
CC {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534};
CC Vmax=0.845 nmol/min/mg enzyme toward metformin
CC {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534};
CC Vmax=0.58 nmol/min/mg enzyme toward guanidine
CC {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534};
CC Vmax=3.385 nmol/min/mg enzyme toward procainamide
CC {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534};
CC Vmax=0.13 nmol/min/mg enzyme toward topotecan
CC {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534};
CC Vmax=0.425 nmol/min/mg enzyme toward estrone sulfate
CC {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534};
CC Vmax=0.945 nmol/min/mg enzyme toward acyclovir
CC {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534};
CC Vmax=0.805 nmol/min/mg enzyme toward ganciclovir
CC {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534};
CC pH dependence:
CC Optimum pH is 9.0. Active from pH 6 to 9.
CC {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Note=Localized at the brush border membranes of
CC the proximal tubules.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q86VL8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86VL8-2; Sequence=VSP_029656, VSP_029658, VSP_029663,
CC VSP_029664;
CC Name=3; Synonyms=MATE2-K;
CC IsoId=Q86VL8-3; Sequence=VSP_029658;
CC Name=4;
CC IsoId=Q86VL8-4; Sequence=VSP_029658, VSP_029662;
CC Name=5;
CC IsoId=Q86VL8-5; Sequence=VSP_029658, VSP_029660, VSP_029661;
CC Name=6; Synonyms=MATE2-B;
CC IsoId=Q86VL8-6; Sequence=VSP_029657, VSP_029659;
CC -!- TISSUE SPECIFICITY: Isoform 3 is predominantly expressed in kidney.
CC Isoform 6 is expressed in brain. {ECO:0000269|PubMed:16807400}.
CC -!- MISCELLANEOUS: [Isoform 6]: Inactive. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; AB250364; BAF36847.1; -; mRNA.
DR EMBL; AB250701; BAF37007.1; -; mRNA.
DR EMBL; AK055758; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BX648861; CAH56154.1; -; mRNA.
DR EMBL; CH471212; EAW50902.1; -; Genomic_DNA.
DR EMBL; CH471212; EAW50904.1; -; Genomic_DNA.
DR EMBL; CH471212; EAW50905.1; -; Genomic_DNA.
DR EMBL; BC035288; AAH35288.1; -; mRNA.
DR EMBL; BC050578; AAH50578.1; -; mRNA.
DR CCDS; CCDS11211.1; -. [Q86VL8-1]
DR CCDS; CCDS58530.1; -. [Q86VL8-4]
DR RefSeq; NP_001093116.1; NM_001099646.1. [Q86VL8-3]
DR RefSeq; NP_001243592.1; NM_001256663.1. [Q86VL8-4]
DR RefSeq; NP_690872.2; NM_152908.3. [Q86VL8-1]
DR AlphaFoldDB; Q86VL8; -.
DR SMR; Q86VL8; -.
DR BioGRID; 127012; 4.
DR IntAct; Q86VL8; 2.
DR STRING; 9606.ENSP00000326671; -.
DR BindingDB; Q86VL8; -.
DR ChEMBL; CHEMBL1743127; -.
DR DrugBank; DB12001; Abemaciclib.
DR DrugBank; DB00787; Acyclovir.
DR DrugBank; DB06288; Amisulpride.
DR DrugBank; DB11901; Apalutamide.
DR DrugBank; DB15233; Avapritinib.
DR DrugBank; DB11817; Baricitinib.
DR DrugBank; DB15463; Belzutifan.
DR DrugBank; DB12267; Brigatinib.
DR DrugBank; DB11791; Capmatinib.
DR DrugBank; DB00501; Cimetidine.
DR DrugBank; DB00537; Ciprofloxacin.
DR DrugBank; DB12483; Copanlisib.
DR DrugBank; DB04574; Estrone sulfate.
DR DrugBank; DB12500; Fedratinib.
DR DrugBank; DB12265; Fexinidazole.
DR DrugBank; DB16628; Fosdenopterin.
DR DrugBank; DB01004; Ganciclovir.
DR DrugBank; DB11978; Glasdegib.
DR DrugBank; DB00536; Guanidine.
DR DrugBank; DB11886; Infigratinib.
DR DrugBank; DB11757; Istradefylline.
DR DrugBank; DB11732; Lasmiditan.
DR DrugBank; DB01137; Levofloxacin.
DR DrugBank; DB00331; Metformin.
DR DrugBank; DB09241; Methylene blue.
DR DrugBank; DB08840; N-methylnicotinamide.
DR DrugBank; DB01203; Nadolol.
DR DrugBank; DB12978; Pexidartinib.
DR DrugBank; DB12615; Plazomicin.
DR DrugBank; DB15822; Pralsetinib.
DR DrugBank; DB01035; Procainamide.
DR DrugBank; DB00205; Pyrimethamine.
DR DrugBank; DB00243; Ranolazine.
DR DrugBank; DB12377; Relebactam.
DR DrugBank; DB15305; Risdiplam.
DR DrugBank; DB12332; Rucaparib.
DR DrugBank; DB00391; Sulpiride.
DR DrugBank; DB06608; Tafenoquine.
DR DrugBank; DB12887; Tazemetostat.
DR DrugBank; DB06137; Tirbanibulin.
DR DrugBank; DB01030; Topotecan.
DR DrugBank; DB14962; Trastuzumab deruxtecan.
DR DrugBank; DB15442; Trilaciclib.
DR DrugBank; DB00440; Trimethoprim.
DR DrugBank; DB11652; Tucatinib.
DR DrugBank; DB00661; Verapamil.
DR DrugCentral; Q86VL8; -.
DR GuidetoPHARMACOLOGY; 1217; -.
DR TCDB; 2.A.66.1.20; the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.
DR iPTMnet; Q86VL8; -.
DR PhosphoSitePlus; Q86VL8; -.
DR BioMuta; SLC47A2; -.
DR DMDM; 74727585; -.
DR MassIVE; Q86VL8; -.
DR PaxDb; Q86VL8; -.
DR PeptideAtlas; Q86VL8; -.
DR PRIDE; Q86VL8; -.
DR ProteomicsDB; 70034; -. [Q86VL8-1]
DR ProteomicsDB; 70035; -. [Q86VL8-2]
DR ProteomicsDB; 70036; -. [Q86VL8-3]
DR ProteomicsDB; 70037; -. [Q86VL8-4]
DR Antibodypedia; 26005; 162 antibodies from 24 providers.
DR DNASU; 146802; -.
DR Ensembl; ENST00000325411.9; ENSP00000326671.5; ENSG00000180638.19. [Q86VL8-1]
DR Ensembl; ENST00000350657.9; ENSP00000338084.6; ENSG00000180638.19. [Q86VL8-4]
DR Ensembl; ENST00000433844.4; ENSP00000391848.3; ENSG00000180638.19. [Q86VL8-3]
DR Ensembl; ENST00000574239.5; ENSP00000458694.1; ENSG00000180638.19. [Q86VL8-6]
DR GeneID; 146802; -.
DR KEGG; hsa:146802; -.
DR MANE-Select; ENST00000433844.4; ENSP00000391848.3; NM_001099646.3; NP_001093116.1. [Q86VL8-3]
DR UCSC; uc002gwe.5; human. [Q86VL8-1]
DR CTD; 146802; -.
DR DisGeNET; 146802; -.
DR GeneCards; SLC47A2; -.
DR HGNC; HGNC:26439; SLC47A2.
DR HPA; ENSG00000180638; Tissue enhanced (brain, choroid plexus, kidney).
DR MIM; 609833; gene.
DR neXtProt; NX_Q86VL8; -.
DR OpenTargets; ENSG00000180638; -.
DR PharmGKB; PA162403847; -.
DR VEuPathDB; HostDB:ENSG00000180638; -.
DR eggNOG; KOG1347; Eukaryota.
DR GeneTree; ENSGT00940000163062; -.
DR HOGENOM; CLU_012893_1_3_1; -.
DR InParanoid; Q86VL8; -.
DR OMA; AAWFELF; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q86VL8; -.
DR TreeFam; TF324441; -.
DR PathwayCommons; Q86VL8; -.
DR Reactome; R-HSA-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR SignaLink; Q86VL8; -.
DR BioGRID-ORCS; 146802; 11 hits in 1062 CRISPR screens.
DR GeneWiki; SLC47A2; -.
DR GenomeRNAi; 146802; -.
DR Pharos; Q86VL8; Tchem.
DR PRO; PR:Q86VL8; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q86VL8; protein.
DR Bgee; ENSG00000180638; Expressed in kidney epithelium and 107 other tissues.
DR ExpressionAtlas; Q86VL8; baseline and differential.
DR Genevisible; Q86VL8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0015299; F:solute:proton antiporter activity; TAS:Reactome.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; TAS:Reactome.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..602
FT /note="Multidrug and toxin extrusion protein 2"
FT /id="PRO_0000311952"
FT TOPO_DOM 1..33
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..66
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..119
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..153
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..248
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..289
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..327
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 349..368
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 390..402
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 424..442
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 464..466
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 488..578
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 579..599
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 600..602
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 503..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..49
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_029656"
FT VAR_SEQ 178..219
FT /note="GWLKGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQ -> AGERLC
FT VPASSNSSTGMAEGAGGGVPIPNPGFVHPPSISLTP (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:16807400"
FT /id="VSP_029657"
FT VAR_SEQ 178..213
FT /note="Missing (in isoform 2, isoform 3, isoform 4 and
FT isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:16807400,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_029658"
FT VAR_SEQ 220..602
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:16807400"
FT /id="VSP_029659"
FT VAR_SEQ 317..398
FT /note="GLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAADTVQAKRSA
FT VSGVLSIVGISLVLGTLISILKNQLGHIFT -> EHAQCGGSLCPGCHLGGHCDLHDSL
FT GAQHRGLCPSGDGSGGRGYCAGQALGRLGRAQHSWHFPGPGHPDKHPEKSAGAYFYQ
FT (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029660"
FT VAR_SEQ 339
FT /note="M -> MRHSHRLAYAAHVTR (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029662"
FT VAR_SEQ 376..381
FT /note="VGISLV -> EMSLPW (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_029663"
FT VAR_SEQ 382..602
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_029664"
FT VAR_SEQ 399..602
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029661"
FT VARIANT 429
FT /note="G -> R (in dbSNP:rs34399035)"
FT /id="VAR_037358"
FT CONFLICT 6
FT /note="D -> E (in Ref. 1; BAF37007)"
FT /evidence="ECO:0000305"
FT CONFLICT 23
FT /note="V -> A (in Ref. 2; AK055758)"
FT /evidence="ECO:0000305"
FT CONFLICT 93
FT /note="D -> G (in Ref. 2; AK055758)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="C -> Y (in Ref. 3; CAH56154)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 602 AA; 65085 MW; 88EB90286AE701D1 CRC64;
MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG
HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL
LCCLPCWALF LNTQHILLLF RQDPDVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQGWL
KGQEEESPFQ TPGLSILHPS HSHLSRASFH LFQKITWPQV LSGVVGNCVN GVANYALVSV
LNLGVRGSAY ANIISQFAQT VFLLLYIVLK KLHLETWAGW SSQCLQDWGP FFSLAVPSML
MICVEWWAYE IGSFLMGLLS VVDLSAQAVI YEVATVTYMI PLGLSIGVCV RVGMALGAAD
TVQAKRSAVS GVLSIVGISL VLGTLISILK NQLGHIFTND EDVIALVSQV LPVYSVFHVF
EAICCVYGGV LRGTGKQAFG AAVNAITYYI IGLPLGILLT FVVRMRIMGL WLGMLACVFL
ATAAFVAYTA RLDWKLAAEE AKKHSGRQQQ QRAESTATRP GPEKAVLSSV ATGSSPGITL
TTYSRSECHV DFFRTPEEAH ALSAPTSRLS VKQLVIRRGA ALGAASATLM VGLTVRILAT
RH
