ID   S47A2_PONAB             Reviewed;         581 AA.
AC   Q5R7E4;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Multidrug and toxin extrusion protein 2;
DE            Short=MATE-2;
DE   AltName: Full=Solute carrier family 47 member 2;
GN   Name=SLC47A2; Synonyms=MATE2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Solute transporter for tetraethylammonium (TEA), 1-methyl-4-
CC       phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin,
CC       creatinine, guanidine, procainamide, topotecan, estrone sulfate,
CC       acyclovir, and ganciclovir. Responsible for the secretion of cationic
CC       drugs across the brush border membranes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; CR860174; CAH92316.1; -; mRNA.
DR   RefSeq; NP_001127538.1; NM_001134066.1.
DR   AlphaFoldDB; Q5R7E4; -.
DR   SMR; Q5R7E4; -.
DR   STRING; 9601.ENSPPYP00000009918; -.
DR   Ensembl; ENSPPYT00000010316; ENSPPYP00000009918; ENSPPYG00000008839.
DR   GeneID; 100174615; -.
DR   KEGG; pon:100174615; -.
DR   CTD; 146802; -.
DR   eggNOG; KOG1347; Eukaryota.
DR   GeneTree; ENSGT00940000163062; -.
DR   InParanoid; Q5R7E4; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   CDD; cd13132; MATE_eukaryotic; 1.
DR   InterPro; IPR045069; MATE_euk.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..581
FT                   /note="Multidrug and toxin extrusion protein 2"
FT                   /id="PRO_0000311953"
FT   TOPO_DOM        1..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..66
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        88..119
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        141..153
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        175..183
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        205..212
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..253
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        274..317
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        339..346
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        368..380
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        402..420
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        442..444
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        445..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        466..557
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        558..578
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        579..581
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          481..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   581 AA;  62780 MW;  8A628641E3D0FA0E CRC64;
     MDSLQDTVPL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG
     HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL
     LCCLPCWALF LNTQHILLLF RQDPEVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQKIT
     WPQVLSGVVG NCVNGVANYA LVSVLNLGVR GSAYANIISQ FAQTVFLLLY IVLKKLHLET
     WAGWSSQCLQ DWGPFFSLAV PSMLMICVEW WAYEIGSFLM GLLSVVDLSA QAVIYEVATV
     TYMRHSHHLA YTAHVARIPL GLSIGVCVRV GMALGAADTV QAKRSAVSGV LSIVGISLVL
     GTLISILKNQ LGHIFTNDED VIALVSQVLP VYSVFHVFEA ICCVYGGVLR GTGKQAFGAA
     VNAITYYIIG LPLGILLTFV VRMRIMGLWL GMLACVFLAT AAFVAYTARL DWKLAAEEAK
     KHSGQQQQQQ RAESTATRSG PEKAVLSSVA TGSSPGITLT TYSRSECHVD LFRTPEEAHT
     LSAPTSRLSV KQLVIRRGAA LGAASATLMV GLTVRILATR H