S49A3_MOUSE
ID S49A3_MOUSE Reviewed; 516 AA.
AC Q8CE47; Q505K1;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Solute carrier family 49 member A3;
DE AltName: Full=Major facilitator superfamily domain-containing protein 7A;
GN Name=Slc49a3; Synonyms=Mfsd7a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AK029021; BAC26248.1; -; mRNA.
DR EMBL; BC094512; AAH94512.1; -; mRNA.
DR CCDS; CCDS19511.1; -.
DR RefSeq; NP_766471.1; NM_172883.2.
DR AlphaFoldDB; Q8CE47; -.
DR SMR; Q8CE47; -.
DR STRING; 10090.ENSMUSP00000031455; -.
DR TCDB; 2.A.1.28.2; the major facilitator superfamily (mfs).
DR iPTMnet; Q8CE47; -.
DR PhosphoSitePlus; Q8CE47; -.
DR MaxQB; Q8CE47; -.
DR PaxDb; Q8CE47; -.
DR PRIDE; Q8CE47; -.
DR ProteomicsDB; 256822; -.
DR Antibodypedia; 42992; 30 antibodies from 15 providers.
DR DNASU; 243197; -.
DR Ensembl; ENSMUST00000031455; ENSMUSP00000031455; ENSMUSG00000029490.
DR GeneID; 243197; -.
DR KEGG; mmu:243197; -.
DR UCSC; uc008yoc.1; mouse.
DR CTD; 243197; -.
DR MGI; MGI:2442629; Mfsd7a.
DR VEuPathDB; HostDB:ENSMUSG00000029490; -.
DR eggNOG; KOG2563; Eukaryota.
DR GeneTree; ENSGT01030000234625; -.
DR HOGENOM; CLU_023132_3_2_1; -.
DR InParanoid; Q8CE47; -.
DR OMA; LASECTF; -.
DR OrthoDB; 702737at2759; -.
DR PhylomeDB; Q8CE47; -.
DR TreeFam; TF314292; -.
DR BioGRID-ORCS; 243197; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q8CE47; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8CE47; protein.
DR Bgee; ENSMUSG00000029490; Expressed in white adipose tissue and 43 other tissues.
DR ExpressionAtlas; Q8CE47; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..516
FT /note="Solute carrier family 49 member A3"
FT /id="PRO_0000273409"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 210
FT /note="A -> S (in Ref. 2; AAH94512)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 516 AA; 54646 MW; FC00C76F548E9157 CRC64;
MAGTMDRLED CNSPETSGTA GDALPSPRVY ARRWVFLLVV SLLSCSNAML WLSFAPVADT
IAQHFFLSMD QVNWLSLIYF VLSIPFGMAA IWVLDSVGLR GATILGAWLN FSGSVLRAVP
CLPVRIPSPF AFFMSGQSLC ALAQTLVVSS PAKLAALWFP EHQRATANMI STMSNPLGLL
IANVLSPALV KKADDIPMML GIYIGPAALA CLLATVCLWE SVPPTPPSTG AANSTSESFL
RGLKLLIQNK AYVLLAVCFG GGIGVFSSFS ALLEQILCAS GYSNEFSGLC GALFIVFGIL
GALLLGLYVD RTKHFTEATK IGLCLTSMTS VAFALVSQLQ GQTLALAAIC SLFGLFGFSV
APVVMELAVE CSFPVGEGAS AGLIFVLGQA EGMLIMLLLT ALTVRRTGPS FSTCQQGEDP
LDWTVSLLLL AGLCTLFTCV LVIFFNTPYR RLEAESGGSS SPTMCARDPR TVSPTQVPPL
ETPGLTPPDE ALKEAPGPAS VSKGHSEWAE TMPRDV