位置:首页 > 蛋白库 > S49A3_MOUSE
S49A3_MOUSE
ID   S49A3_MOUSE             Reviewed;         516 AA.
AC   Q8CE47; Q505K1;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Solute carrier family 49 member A3;
DE   AltName: Full=Major facilitator superfamily domain-containing protein 7A;
GN   Name=Slc49a3; Synonyms=Mfsd7a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Skin;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK029021; BAC26248.1; -; mRNA.
DR   EMBL; BC094512; AAH94512.1; -; mRNA.
DR   CCDS; CCDS19511.1; -.
DR   RefSeq; NP_766471.1; NM_172883.2.
DR   AlphaFoldDB; Q8CE47; -.
DR   SMR; Q8CE47; -.
DR   STRING; 10090.ENSMUSP00000031455; -.
DR   TCDB; 2.A.1.28.2; the major facilitator superfamily (mfs).
DR   iPTMnet; Q8CE47; -.
DR   PhosphoSitePlus; Q8CE47; -.
DR   MaxQB; Q8CE47; -.
DR   PaxDb; Q8CE47; -.
DR   PRIDE; Q8CE47; -.
DR   ProteomicsDB; 256822; -.
DR   Antibodypedia; 42992; 30 antibodies from 15 providers.
DR   DNASU; 243197; -.
DR   Ensembl; ENSMUST00000031455; ENSMUSP00000031455; ENSMUSG00000029490.
DR   GeneID; 243197; -.
DR   KEGG; mmu:243197; -.
DR   UCSC; uc008yoc.1; mouse.
DR   CTD; 243197; -.
DR   MGI; MGI:2442629; Mfsd7a.
DR   VEuPathDB; HostDB:ENSMUSG00000029490; -.
DR   eggNOG; KOG2563; Eukaryota.
DR   GeneTree; ENSGT01030000234625; -.
DR   HOGENOM; CLU_023132_3_2_1; -.
DR   InParanoid; Q8CE47; -.
DR   OMA; LASECTF; -.
DR   OrthoDB; 702737at2759; -.
DR   PhylomeDB; Q8CE47; -.
DR   TreeFam; TF314292; -.
DR   BioGRID-ORCS; 243197; 1 hit in 73 CRISPR screens.
DR   PRO; PR:Q8CE47; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q8CE47; protein.
DR   Bgee; ENSMUSG00000029490; Expressed in white adipose tissue and 43 other tissues.
DR   ExpressionAtlas; Q8CE47; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..516
FT                   /note="Solute carrier family 49 member A3"
FT                   /id="PRO_0000273409"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          453..516
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        453..479
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        210
FT                   /note="A -> S (in Ref. 2; AAH94512)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   516 AA;  54646 MW;  FC00C76F548E9157 CRC64;
     MAGTMDRLED CNSPETSGTA GDALPSPRVY ARRWVFLLVV SLLSCSNAML WLSFAPVADT
     IAQHFFLSMD QVNWLSLIYF VLSIPFGMAA IWVLDSVGLR GATILGAWLN FSGSVLRAVP
     CLPVRIPSPF AFFMSGQSLC ALAQTLVVSS PAKLAALWFP EHQRATANMI STMSNPLGLL
     IANVLSPALV KKADDIPMML GIYIGPAALA CLLATVCLWE SVPPTPPSTG AANSTSESFL
     RGLKLLIQNK AYVLLAVCFG GGIGVFSSFS ALLEQILCAS GYSNEFSGLC GALFIVFGIL
     GALLLGLYVD RTKHFTEATK IGLCLTSMTS VAFALVSQLQ GQTLALAAIC SLFGLFGFSV
     APVVMELAVE CSFPVGEGAS AGLIFVLGQA EGMLIMLLLT ALTVRRTGPS FSTCQQGEDP
     LDWTVSLLLL AGLCTLFTCV LVIFFNTPYR RLEAESGGSS SPTMCARDPR TVSPTQVPPL
     ETPGLTPPDE ALKEAPGPAS VSKGHSEWAE TMPRDV
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024