S49A3_XENTR
ID S49A3_XENTR Reviewed; 482 AA.
AC Q28FF3; F6ZLK2; Q6P3R2;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2018, sequence version 2.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Solute carrier family 49 member A3;
DE AltName: Full=Major facilitator superfamily domain-containing protein 7-a;
DE AltName: Full=Major facilitator superfamily domain-containing protein 7-b;
DE AltName: Full=Myosin light polypeptide 5 regulatory protein;
DE Short=MYL5;
GN Name=slc49a3; Synonyms=mfsd7-A, mfsd7-B; ORFNames=TEgg026p17.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q28FF3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q28FF3-2; Sequence=VSP_059311;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; CR761997; CAJ83663.1; -; mRNA.
DR EMBL; AAMC01051013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01051014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01051015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC063895; AAH63895.1; -; mRNA.
DR RefSeq; NP_989260.1; NM_203929.1. [Q28FF3-2]
DR RefSeq; XP_012813793.1; XM_012958339.2. [Q28FF3-1]
DR AlphaFoldDB; Q28FF3; -.
DR SMR; Q28FF3; -.
DR STRING; 8364.ENSXETP00000010697; -.
DR PaxDb; Q28FF3; -.
DR DNASU; 394873; -.
DR Ensembl; ENSXETT00000010697; ENSXETP00000010697; ENSXETG00000004914.
DR GeneID; 394873; -.
DR KEGG; xtr:394873; -.
DR CTD; 84179; -.
DR Xenbase; XB-GENE-5740366; slc49a3.
DR eggNOG; KOG2563; Eukaryota.
DR InParanoid; Q28FF3; -.
DR OMA; LASECTF; -.
DR OrthoDB; 702737at2759; -.
DR TreeFam; TF314292; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000004914; Expressed in testis and 12 other tissues.
DR ExpressionAtlas; Q28FF3; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..482
FT /note="Solute carrier family 49 member A3"
FT /id="PRO_0000273411"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 437..457
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 400..415
FT /note="Missing (in isoform 2)"
FT /id="VSP_059311"
FT CONFLICT 137..141
FT /note="SYTGI -> TYTGR (in Ref. 1; CAJ83663)"
FT /evidence="ECO:0000305"
FT CONFLICT 227
FT /note="A -> T (in Ref. 1; CAJ83663)"
FT CONFLICT 480
FT /note="H -> N (in Ref. 1; CAJ83663)"
SQ SEQUENCE 482 AA; 52188 MW; 33BFE47919737941 CRC64;
MAEDVSSGEQ TEDQAGQPLL NGEIIASNGD KCQFRTYKRR WFVLGVICLL SCTNAMLWIS
FAPVADVTAS FFKCSLDVVN YLSLVYLIIA IPVGFGASWL IDTLGLKYAI VFSSWLNMIG
SIIRCGAIVP YLNPSGSYTG IYYLFTGQSL CAIAQPLVLF VPAKLASVWF PEHQRATANM
IASMSNPLGV LLANIISPSV VTKEEYIAHM LGIYTVPAIA ACILATAGIR AKSPPTPPSA
SAFNSASEPF IAGIRQLLTN RAYVILMLCF GAGIGIFTAI SSFLEQILCF RGYSNLFAGV
CGALFIFFGF IGAFVCGLYV DRTKKFKEVV KTCFALTALT SIAFALVINF REQTVLVACV
CSLLGLFGFA ISPVGMELAV ECSYPVGEGS STGLAFISGQ IQGIIYMILF QKLTRPFATS
GPSPCGMNQT EIYDWSTSML VMAALCSFGS CIFIIFFHTK YKRLLAEVNF NGLKEELNTH
ET
