BET12_ARATH
ID BET12_ARATH Reviewed; 130 AA.
AC Q94CG2; O23301; Q8GYR9;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 4.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Bet1-like SNARE 1-2;
DE Short=AtBET12;
DE AltName: Full=Bet1/Sft1-like SNARE 14b;
DE Short=AtBS14b;
GN Name=BET12; OrderedLocusNames=At4g14455; ORFNames=FCAALL.379;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 8-117.
RX PubMed=11445081; DOI=10.1016/s0014-5793(01)02599-6;
RA Tai W.C.S., Banfield D.K.;
RT "AtBS14a and AtBS14b, two Bet1/Sft1-like SNAREs from Arabidopsis thaliana
RT that complement mutations in the yeast SFT1 gene.";
RL FEBS Lett. 500:177-182(2001).
CC -!- FUNCTION: Required for vesicular transport from the ER to the Golgi
CC complex. Functions as a SNARE associated with ER-derived vesicles (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type IV membrane protein {ECO:0000250}. Endoplasmic reticulum
CC membrane {ECO:0000250}; Single-pass type IV membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BET1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB10224.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g14450 has been split into 2 genes: At4g14450 and At4g14455.; Evidence={ECO:0000305};
CC Sequence=CAB78487.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g14450 has been split into 2 genes: At4g14450 and At4g14455.; Evidence={ECO:0000305};
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DR EMBL; Z97336; CAB10224.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161539; CAB78487.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83447.1; -; Genomic_DNA.
DR EMBL; AK117428; BAC42093.1; -; mRNA.
DR EMBL; AY033334; AAK51151.1; -; mRNA.
DR RefSeq; NP_849384.1; NM_179053.3.
DR AlphaFoldDB; Q94CG2; -.
DR SMR; Q94CG2; -.
DR BioGRID; 12388; 242.
DR IntAct; Q94CG2; 237.
DR STRING; 3702.AT4G14455.1; -.
DR PaxDb; Q94CG2; -.
DR PRIDE; Q94CG2; -.
DR ProteomicsDB; 240462; -.
DR EnsemblPlants; AT4G14455.1; AT4G14455.1; AT4G14455.
DR GeneID; 827091; -.
DR Gramene; AT4G14455.1; AT4G14455.1; AT4G14455.
DR KEGG; ath:AT4G14455; -.
DR Araport; AT4G14455; -.
DR TAIR; locus:1005716319; AT4G14455.
DR eggNOG; KOG3385; Eukaryota.
DR HOGENOM; CLU_086133_0_0_1; -.
DR InParanoid; Q94CG2; -.
DR OMA; KMDSARG; -.
DR OrthoDB; 1557133at2759; -.
DR PhylomeDB; Q94CG2; -.
DR PRO; PR:Q94CG2; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q94CG2; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030173; C:integral component of Golgi membrane; IEA:InterPro.
DR GO; GO:0005484; F:SNAP receptor activity; NAS:TAIR.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; NAS:TAIR.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd15853; SNARE_Bet1; 1.
DR InterPro; IPR039897; BET1.
DR InterPro; IPR039899; BET1_SNARE.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR12791; PTHR12791; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW Membrane; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..130
FT /note="Bet1-like SNARE 1-2"
FT /id="PRO_0000206888"
FT TOPO_DOM 1..106
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..122
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..130
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT DOMAIN 33..95
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT COILED 40..82
FT /evidence="ECO:0000255"
FT CONFLICT 65
FT /note="E -> K (in Ref. 5; AAK51151)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 130 AA; 15207 MW; 64B12F2BCD11DCFF CRC64;
MNFRRENRAS RTSLFDGLDG LEEGRLRASS SYAHDERDND EALENLQDRV SFLKRVTGDI
HEEVENHNRL LDKVGNKMDS ARGIMSGTIN RFKLVFEKKS NRKSCKLIAY FVLLFLIMYY
LIRLLNYIKG
