BET1L_DANRE
ID BET1L_DANRE Reviewed; 110 AA.
AC Q68EL3;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=BET1-like protein;
GN Name=bet1l; ORFNames=zgc:100789;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000312|EMBL:AAH80213.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH80213.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Vesicle SNARE required for targeting and fusion of retrograde
CC transport vesicles with the Golgi complex. Required for the integrity
CC of the Golgi complex (By similarity). {ECO:0000250|UniProtKB:O35152}.
CC -!- SUBUNIT: Component of a SNARE complex consisting of stx5, ykt6, gosr2
CC and bet1l. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type IV membrane protein {ECO:0000250}.
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DR EMBL; BC080213; AAH80213.1; -; mRNA.
DR RefSeq; NP_001003998.1; NM_001003998.1.
DR RefSeq; XP_009296054.1; XM_009297779.2.
DR AlphaFoldDB; Q68EL3; -.
DR SMR; Q68EL3; -.
DR Ensembl; ENSDART00000142794; ENSDARP00000113973; ENSDARG00000032037.
DR GeneID; 445493; -.
DR KEGG; dre:445493; -.
DR CTD; 51272; -.
DR ZFIN; ZDB-GENE-040822-2; bet1l.
DR GeneTree; ENSGT00940000174954; -.
DR InParanoid; Q68EL3; -.
DR OrthoDB; 1536545at2759; -.
DR PhylomeDB; Q68EL3; -.
DR TreeFam; TF323307; -.
DR Reactome; R-DRE-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DRE-6811438; Intra-Golgi traffic.
DR PRO; PR:Q68EL3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 25.
DR Bgee; ENSDARG00000032037; Expressed in swim bladder and 21 other tissues.
DR ExpressionAtlas; Q68EL3; baseline.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0000138; C:Golgi trans cisterna; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IEA:InterPro.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:2000156; P:regulation of retrograde vesicle-mediated transport, Golgi to ER; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR CDD; cd15853; SNARE_Bet1; 1.
DR InterPro; IPR039897; BET1.
DR InterPro; IPR039899; BET1_SNARE.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR12791; PTHR12791; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 3: Inferred from homology;
KW Coiled coil; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..110
FT /note="BET1-like protein"
FT /id="PRO_0000233060"
FT TOPO_DOM 1..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..110
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT DOMAIN 14..76
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
SQ SEQUENCE 110 AA; 12348 MW; 9918FF11EB7B3670 CRC64;
MADPWNRGHG AVDDMLDAEN KRMAENLASK VSRLKSLAYD IDKDAEEQNA YLDGMDSNFL
SATGLLTGSV KRFSTMVRSG RDNRKILCYV SVGLVVAFFL LYYLVSRMQN
