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S52A2_PIG
ID   S52A2_PIG               Reviewed;         446 AA.
AC   Q863Y7;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Solute carrier family 52, riboflavin transporter, member 2;
DE   AltName: Full=Endogenous retrovirus A receptor;
DE   AltName: Full=Protein GPR172B;
DE   AltName: Full=Riboflavin transporter 1;
GN   Name=SLC52A2; Synonyms=GPR172B, RFT1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION AS A VIRAL RECEPTOR.
RX   PubMed=12740431; DOI=10.1073/pnas.1138025100;
RA   Ericsson T.A., Takeuchi Y., Templin C., Quinn G., Farhadian S.F.,
RA   Wood J.C., Oldmixon B.A., Suling K.M., Ishii J.K., Kitagawa Y.,
RA   Miyazawa T., Salomon D.R., Weiss R.A., Patience C.;
RT   "Identification of receptors for pig endogenous retrovirus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:6759-6764(2003).
CC   -!- FUNCTION: Plasma membrane transporter mediating the uptake by cells of
CC       the water soluble vitamin B2/riboflavin that plays a key role in
CC       biochemical oxidation-reduction reactions of the carbohydrate, lipid,
CC       and amino acid metabolism. May also act as a receptor for 4-
CC       hydroxybutyrate. {ECO:0000250|UniProtKB:Q9HAB3}.
CC   -!- FUNCTION: (Microbial infection) In case of infection by porcine
CC       endogenous retrovirus (PERV-A), acts as a cell receptor to retroviral
CC       envelopes. {ECO:0000269|PubMed:12740431}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=riboflavin(in) = riboflavin(out); Xref=Rhea:RHEA:35015,
CC         ChEBI:CHEBI:57986; Evidence={ECO:0000250|UniProtKB:Q9HAB3};
CC   -!- ACTIVITY REGULATION: Riboflavin transport is Na(+)-independent but
CC       moderately pH-sensitive (By similarity). Activity is strongly inhibited
CC       by riboflavin analogs, such as lumiflavin (By similarity). Weakly
CC       inhibited by flavin adenine dinucleotide (FAD) and flavin
CC       mononucleotide (FMN) (By similarity). {ECO:0000250|UniProtKB:Q9HAB3}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9HAB3};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the riboflavin transporter family.
CC       {ECO:0000305}.
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DR   EMBL; AY134475; AAM95457.1; -; mRNA.
DR   RefSeq; NP_001004033.1; NM_001004033.1.
DR   AlphaFoldDB; Q863Y7; -.
DR   STRING; 9823.ENSSSCP00000006317; -.
DR   PaxDb; Q863Y7; -.
DR   GeneID; 445519; -.
DR   KEGG; ssc:445519; -.
DR   CTD; 79581; -.
DR   eggNOG; KOG4255; Eukaryota.
DR   InParanoid; Q863Y7; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0062124; F:4-hydroxybutyrate receptor activity; ISS:UniProtKB.
DR   GO; GO:0032217; F:riboflavin transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0001618; F:virus receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0032218; P:riboflavin transport; ISS:UniProtKB.
DR   InterPro; IPR009357; Riboflavin_transptr.
DR   PANTHER; PTHR12929; PTHR12929; 1.
DR   Pfam; PF06237; DUF1011; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; Host cell receptor for virus entry; Membrane;
KW   Receptor; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..446
FT                   /note="Solute carrier family 52, riboflavin transporter,
FT                   member 2"
FT                   /id="PRO_0000042635"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          228..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        129
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   446 AA;  45828 MW;  C4DC41C711E274E0 CRC64;
     MAAPTLARLV LTHLLVALFG MGSWAAINGI WVELPVVVKD LPEGWSLPSY LSVLVALGNL
     GLLVVTLWRR LAPGKGERAP IQVVQALSVV GTALLAPLWQ HLTVMAGQVH SVAFLALTFV
     LALACCASNV TYLPFLSRLP PPFLRSFFLG QGLSALLPCV LALGQGVGRL ECPPAPANGT
     PGPPLDFPER FSASAFFGAL TALLVISAAA FQGLLLLLPS LVSIPTEGSG TGLRGGAPGV
     EEEEEEEASP LQEPPSQAAG NTPSPDPAAH RLLSARGACL LGLLATTSAL TNGVLPAVQS
     YSSLPYGRLA YHLAVVLGSA SNPLACFLAM GILCRSLAGL GGLSLLGTLF GAYLMALAIL
     SPCPPLVGTS AGMVLVVVLW ALCLGVFSYV KVATSSLLHG GGPPALLAAG VAIQVGSLLG
     AVTMFPPTSI YRVFQSRKDC VDPCEP
 
 
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