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S52A3_OSMMO
ID   S52A3_OSMMO             Reviewed;         410 AA.
AC   C1BKZ7;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Solute carrier family 52, riboflavin transporter, member 3;
DE   AltName: Full=Riboflavin transporter 2;
DE            Short=RFT2;
GN   Name=slc52a3; Synonyms=rft2;
OS   Osmerus mordax (Rainbow smelt) (Atherina mordax).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Stomiati; Osmeriformes; Osmeridae;
OC   Osmerus.
OX   NCBI_TaxID=8014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RA   von Schalburg K., Leong J., Cooper G., Davidson W.S., Koop B.F.;
RT   "Osmerus mordax full-length cDNAs.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plasma membrane transporter mediating the uptake by cells of
CC       the water soluble vitamin B2/riboflavin that plays a key role in
CC       biochemical oxidation-reduction reactions of the carbohydrate, lipid,
CC       and amino acid metabolism. {ECO:0000250|UniProtKB:Q9NQ40}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=riboflavin(in) = riboflavin(out); Xref=Rhea:RHEA:35015,
CC         ChEBI:CHEBI:57986; Evidence={ECO:0000250|UniProtKB:Q9NQ40};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the riboflavin transporter family.
CC       {ECO:0000305}.
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DR   EMBL; BT075276; ACO09700.1; -; mRNA.
DR   AlphaFoldDB; C1BKZ7; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0032217; F:riboflavin transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR009357; Riboflavin_transptr.
DR   PANTHER; PTHR12929; PTHR12929; 2.
DR   Pfam; PF06237; DUF1011; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..410
FT                   /note="Solute carrier family 52, riboflavin transporter,
FT                   member 3"
FT                   /id="PRO_0000399795"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        157
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   410 AA;  44571 MW;  102A226C32BDE98A CRC64;
     MAILIYALAC AFGLGSWLAI NGLWVELPII VTTLPEGWEL PSYLTVIIQL ANLGPLLVTL
     MHKLCPGRLK ESVVIYTILC IGVLACFLLA FFLGRDNCGG WGPAQRSLLH HYFLPGTSGL
     HLLSHLPALH DAAACPLHHH TEGGDTYVLQ TQYLPPNFTT EVFFFFLAVM MCISLAAFWK
     LNRLPRTFEV STENLVPDSV SSVCSGLDNP AVRTNSQKHL CEVTSQARPL LTKSGHSMFQ
     LTFIYLMVVW VNGTTNGLLP SVQTYSCMPY GNLAYHLSAA LASVANPVAC IVAMFFPKRS
     LVFLGLLCVM GTGFASYNMA MAAMSPCPLL QKSALGEAII VLSWVFFTGS LSYVKVMVGV
     ILRDESHSAL VWCGAAAQIG SLIGSVIMFP LINMYNLFQS GDTCSTKCPL
 
 
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