ID   S5A3B_DANRE             Reviewed;         452 AA.
AC   Q6GMG6;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Solute carrier family 52, riboflavin transporter, member 3-B;
DE   AltName: Full=Riboflavin transporter 2-B;
DE            Short=RFT2-B;
GN   Name=slc52a3b; Synonyms=rft2b; ORFNames=zgc:91890;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plasma membrane transporter mediating the uptake by cells of
CC       the water soluble vitamin B2/riboflavin that plays a key role in
CC       biochemical oxidation-reduction reactions of the carbohydrate, lipid,
CC       and amino acid metabolism. {ECO:0000250|UniProtKB:Q9NQ40}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=riboflavin(in) = riboflavin(out); Xref=Rhea:RHEA:35015,
CC         ChEBI:CHEBI:57986; Evidence={ECO:0000250|UniProtKB:Q9NQ40};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the riboflavin transporter family.
CC       {ECO:0000305}.
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DR   EMBL; BC074088; AAH74088.1; -; mRNA.
DR   RefSeq; NP_001002182.1; NM_001002182.1.
DR   AlphaFoldDB; Q6GMG6; -.
DR   STRING; 7955.ENSDARP00000006845; -.
DR   PaxDb; Q6GMG6; -.
DR   PRIDE; Q6GMG6; -.
DR   Ensembl; ENSDART00000017307; ENSDARP00000006845; ENSDARG00000018980.
DR   GeneID; 431729; -.
DR   KEGG; dre:431729; -.
DR   ZFIN; ZDB-GENE-040704-21; zgc:91890.
DR   eggNOG; KOG4255; Eukaryota.
DR   GeneTree; ENSGT00390000003774; -.
DR   HOGENOM; CLU_034789_1_0_1; -.
DR   InParanoid; Q6GMG6; -.
DR   OMA; VIYCIVG; -.
DR   OrthoDB; 757564at2759; -.
DR   PhylomeDB; Q6GMG6; -.
DR   TreeFam; TF314820; -.
DR   PRO; PR:Q6GMG6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   Bgee; ENSDARG00000018980; Expressed in zone of skin and 36 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0032217; F:riboflavin transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0032218; P:riboflavin transport; IBA:GO_Central.
DR   InterPro; IPR009357; Riboflavin_transptr.
DR   PANTHER; PTHR12929; PTHR12929; 1.
DR   Pfam; PF06237; DUF1011; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..452
FT                   /note="Solute carrier family 52, riboflavin transporter,
FT                   member 3-B"
FT                   /id="PRO_0000399794"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        168
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        174
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        179
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        193
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   452 AA;  49108 MW;  AFC1AC64DAE1E7EC CRC64;
     MSLFTHVLAC LFGIGSWVAI NGMWVELPLI VTAIPEGWLL PSYLTIIIQM ANIGPLFITL
     MHRFRPGVLD ERPVIYTIVA VGVVATFLLA FLWKHTLTFG DGEHSAALLS LSFLLSVVDC
     TSSVTFLPFM MRLQPQYLTT YFIGEGLSGL VPALVALVQG VGVVHCKNAS ANANFSLGNI
     SQSLLETHYQ PANFSTQGFF LFLSAMMMVC LGAFLLLNLH PAVAREHKSM KGYIDDSRRV
     EKIDLSQSPN DETPEQRPML DFPEGSAIKQ RSSFGKGTYS RTELVFIFVV LAWVNALTNA
     VLPSVQSYSC LPYGNQAYHL AATLSSVANP VACFIAMFVP IRSLVLMGVL TVTGTGFGAY
     IMAMAALSPC PLLINDDLGA ALIVITWVIF VLSLSYVKVI IGVILRDEGH SALVWCGAVV
     QLGSMLGALS MFPLISVYRL FQSGDPCNTK CP