BET1L_RAT
ID BET1L_RAT Reviewed; 111 AA.
AC O35152; Q6PCU6;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=BET1-like protein;
DE AltName: Full=Golgi SNARE with a size of 15 kDa;
DE Short=GOS-15;
DE Short=GS15;
DE AltName: Full=Vesicle transport protein GOS15;
GN Name=Bet1l {ECO:0000312|RGD:71051}; Synonyms=Gs15;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAB66320.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Brain {ECO:0000269|PubMed:9242691};
RX PubMed=9242691; DOI=10.1074/jbc.272.32.20162;
RA Xu Y., Wong S.H., Zhang T., Subramaniam V.N., Hong W.;
RT "GS15, a 15-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor
RT attachment protein receptor (SNARE) homologous to rbet1.";
RL J. Biol. Chem. 272:20162-20166(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND IDENTIFICATION IN A COMPLEX WITH STX5;
RP YKT6 AND GOSR2.
RX PubMed=12388752; DOI=10.1091/mbc.e02-01-0004;
RA Xu Y., Martin S., James D.E., Hong W.;
RT "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is
RT implicated in traffic in the early cisternae of the Golgi apparatus.";
RL Mol. Biol. Cell 13:3493-3507(2002).
RN [4]
RP SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=14742712; DOI=10.1091/mbc.e03-08-0625;
RA Volchuk A., Ravazzola M., Perrelet A., Eng W.S., Di Liberto M.,
RA Varlamov O., Fukasawa M., Engel T., Sollner T.H., Rothman J.E., Orci L.;
RT "Countercurrent distribution of two distinct SNARE complexes mediating
RT transport within the Golgi stack.";
RL Mol. Biol. Cell 15:1506-1518(2004).
CC -!- FUNCTION: Vesicle SNARE required for targeting and fusion of retrograde
CC transport vesicles with the Golgi complex. Required for the integrity
CC of the Golgi complex. {ECO:0000269|PubMed:12388752,
CC ECO:0000269|PubMed:14742712}.
CC -!- SUBUNIT: Component of a SNARE complex consisting of STX5, YKT6, GOSR2
CC and BET1L. {ECO:0000269|PubMed:12388752}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type IV
CC membrane protein. Golgi apparatus, trans-Golgi network membrane.
CC Note=Present throughout the Golgi apparatus, with strongly increasing
CC concentration from cis-Golgi to the trans-Golgi face of the stacks.
CC -!- TISSUE SPECIFICITY: Widely expressed. Highest levels in heart, liver,
CC skeletal muscle and kidney. {ECO:0000269|PubMed:9242691}.
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DR EMBL; AF003998; AAB66320.1; -; mRNA.
DR EMBL; BC059138; AAH59138.1; -; mRNA.
DR RefSeq; NP_062241.2; NM_019368.3.
DR RefSeq; XP_006230636.1; XM_006230574.3.
DR AlphaFoldDB; O35152; -.
DR SMR; O35152; -.
DR CORUM; O35152; -.
DR IntAct; O35152; 4.
DR STRING; 10116.ENSRNOP00000017684; -.
DR jPOST; O35152; -.
DR PaxDb; O35152; -.
DR DNASU; 54400; -.
DR GeneID; 54400; -.
DR KEGG; rno:54400; -.
DR UCSC; RGD:71051; rat.
DR CTD; 51272; -.
DR RGD; 71051; Bet1l.
DR eggNOG; KOG3385; Eukaryota.
DR InParanoid; O35152; -.
DR OrthoDB; 1536545at2759; -.
DR PhylomeDB; O35152; -.
DR TreeFam; TF323307; -.
DR Reactome; R-RNO-6807878; COPI-mediated anterograde transport.
DR Reactome; R-RNO-6811438; Intra-Golgi traffic.
DR PRO; PR:O35152; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005768; C:endosome; ISO:RGD.
DR GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR GO; GO:0000139; C:Golgi membrane; IDA:RGD.
DR GO; GO:0005795; C:Golgi stack; IDA:RGD.
DR GO; GO:0000138; C:Golgi trans cisterna; IBA:GO_Central.
DR GO; GO:0005798; C:Golgi-associated vesicle; IDA:RGD.
DR GO; GO:0030173; C:integral component of Golgi membrane; IDA:RGD.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IDA:RGD.
DR GO; GO:0005484; F:SNAP receptor activity; ISO:RGD.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:2000156; P:regulation of retrograde vesicle-mediated transport, Golgi to ER; ISO:RGD.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISO:RGD.
DR CDD; cd15853; SNARE_Bet1; 1.
DR InterPro; IPR039897; BET1.
DR InterPro; IPR039899; BET1_SNARE.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR12791; PTHR12791; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Golgi apparatus; Membrane; Phosphoprotein; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..111
FT /note="BET1-like protein"
FT /id="PRO_0000233059"
FT TOPO_DOM 1..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..111
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT DOMAIN 15..77
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NYM9"
FT MOD_RES 37
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NYM9"
FT CONFLICT 17
FT /note="V -> L (in Ref. 2; AAH59138)"
FT /evidence="ECO:0000305"
FT CONFLICT 84
FT /note="T -> N (in Ref. 2; AAH59138)"
FT /evidence="ECO:0000305"
FT CONFLICT 106
FT /note="F -> L (in Ref. 2; AAH59138)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 111 AA; 12417 MW; 905EDA73F6AEB4B4 CRC64;
MADWTRAQSS GAVEEIVDRE NKRMADSLAS KVTRLKSLAL DIDRDTEDQN RYLDGMDSDF
TSVTGLLTGS VKRFSTVARS GRDTRKLLCG MAVVLIVAFF ILSYLFSRTR T
