ID   S66A2_BOVIN             Reviewed;         253 AA.
AC   Q0VCC1;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Solute carrier family 66 member 2 {ECO:0000305};
DE   AltName: Full=PQ-loop repeat-containing protein 1;
GN   Name=SLC66A2; Synonyms=PQLC1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC120242; AAI20243.1; -; mRNA.
DR   RefSeq; NP_001070361.1; NM_001076893.1.
DR   AlphaFoldDB; Q0VCC1; -.
DR   Ensembl; ENSBTAT00000073622; ENSBTAP00000070387; ENSBTAG00000054103.
DR   GeneID; 533304; -.
DR   KEGG; bta:533304; -.
DR   CTD; 80148; -.
DR   VEuPathDB; HostDB:ENSBTAG00000054103; -.
DR   VGNC; VGNC:106934; SLC66A2.
DR   GeneTree; ENSGT00390000002381; -.
DR   InParanoid; Q0VCC1; -.
DR   OrthoDB; 1259147at2759; -.
DR   Proteomes; UP000009136; Chromosome 24.
DR   Bgee; ENSBTAG00000054103; Expressed in corpus epididymis and 105 other tissues.
DR   ExpressionAtlas; Q0VCC1; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0045332; P:phospholipid translocation; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   InterPro; IPR006603; PQ-loop_rpt.
DR   Pfam; PF04193; PQ-loop; 2.
DR   SMART; SM00679; CTNS; 2.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..253
FT                   /note="Solute carrier family 66 member 2"
FT                   /id="PRO_0000282429"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          14..80
FT                   /note="PQ-loop 1"
FT   DOMAIN          160..215
FT                   /note="PQ-loop 2"
SQ   SEQUENCE   253 AA;  28460 MW;  093ACF4D93C0BAEE CRC64;
     MEAEGLGWLL VPLHQLVSWG AAGAMVFGGV VPYIPQYRDI RRTQNAEGFS TYVCLVLLVA
     NILRILFWFG RHFESPLLWQ SVVMILTMLL MLKLCTEVRV ANELNLKRRV FSDFDPHHFW
     HWSSFADYVQ CVLAFTGVAG YITYLSIDSA LFVETLGFLA VLTEAMLGVP QLYRNHRHQS
     TEGMSIKMVL MWTSGDTFKT AYFLLNGAPL QFSVCGLLQV LVDLAILGQA YVFTRYPLKP
     APHAAHPASA KAL