S66A2_RAT
ID S66A2_RAT Reviewed; 271 AA.
AC Q5M880;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Solute carrier family 66 member 2 {ECO:0000305};
DE AltName: Full=PQ-loop repeat-containing protein 1;
GN Name=Slc66a2; Synonyms=Pqlc1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Liver, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5M880-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5M880-2; Sequence=VSP_024150;
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DR EMBL; BC079072; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC088186; AAH88186.1; -; mRNA.
DR RefSeq; NP_001013207.1; NM_001013189.1. [Q5M880-2]
DR RefSeq; XP_006255014.1; XM_006254952.3. [Q5M880-1]
DR RefSeq; XP_006255015.1; XM_006254953.3. [Q5M880-1]
DR RefSeq; XP_017456493.1; XM_017601004.1. [Q5M880-1]
DR AlphaFoldDB; Q5M880; -.
DR STRING; 10116.ENSRNOP00000023433; -.
DR iPTMnet; Q5M880; -.
DR PhosphoSitePlus; Q5M880; -.
DR PaxDb; Q5M880; -.
DR Ensembl; ENSRNOT00000114669; ENSRNOP00000086993; ENSRNOG00000059215. [Q5M880-1]
DR GeneID; 361352; -.
DR KEGG; rno:361352; -.
DR CTD; 80148; -.
DR RGD; 1305223; Pqlc1.
DR eggNOG; KOG2913; Eukaryota.
DR GeneTree; ENSGT00390000002381; -.
DR HOGENOM; CLU_049047_2_0_1; -.
DR InParanoid; Q5M880; -.
DR OMA; FKMWFFF; -.
DR OrthoDB; 1259147at2759; -.
DR PhylomeDB; Q5M880; -.
DR TreeFam; TF313072; -.
DR PRO; PR:Q5M880; -.
DR Proteomes; UP000002494; Chromosome 18.
DR Bgee; ENSRNOG00000059215; Expressed in liver and 20 other tissues.
DR Genevisible; Q5M880; RN.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0045332; P:phospholipid translocation; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR InterPro; IPR006603; PQ-loop_rpt.
DR Pfam; PF04193; PQ-loop; 2.
DR SMART; SM00679; CTNS; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..271
FT /note="Solute carrier family 66 member 2"
FT /id="PRO_0000282432"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 14..80
FT /note="PQ-loop 1"
FT DOMAIN 149..215
FT /note="PQ-loop 2"
FT MOD_RES 110
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT VAR_SEQ 131..154
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024150"
SQ SEQUENCE 271 AA; 30571 MW; FE5D3638DC252E24 CRC64;
MEAEGLGWLL VPLHQLVSWV AAGAMVFGGV VPYIPQYRDI RRTQNADGFS THVCLVLLVA
NILRILFWFG RHFESPLLWQ SIVMILTMLL MLKLCTEVRV ANELNVKRRS FAATDSKDEE
LRVPPRRPYL DFDPHHFWHW SSFADYVQCV LAFTGVAGYI TYLSIDSALF VETLGFLAVL
TEAMLGVPQL YRNYRHRSTE GMSLKMVLMW TSGDTFKTAY FLLNGAPLQF SVCGLLQVMV
DLAILGQAYA FAHHPQKPAP HAVHPASAKA L
