ID   S66A2_XENLA             Reviewed;         250 AA.
AC   Q6NRS2;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Solute carrier family 66 member 2 {ECO:0000305};
DE   AltName: Full=PQ-loop repeat-containing protein 1;
GN   Name=slc66a2; Synonyms=pqlc1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC070652; AAH70652.1; -; mRNA.
DR   RefSeq; NP_001084833.1; NM_001091364.1.
DR   AlphaFoldDB; Q6NRS2; -.
DR   DNASU; 431879; -.
DR   GeneID; 431879; -.
DR   KEGG; xla:431879; -.
DR   CTD; 431879; -.
DR   Xenbase; XB-GENE-988369; slc66a2.1.L.
DR   OrthoDB; 1259147at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 431879; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006603; PQ-loop_rpt.
DR   Pfam; PF04193; PQ-loop; 2.
DR   SMART; SM00679; CTNS; 2.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..250
FT                   /note="Solute carrier family 66 member 2"
FT                   /id="PRO_0000282433"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          14..80
FT                   /note="PQ-loop 1"
FT   DOMAIN          149..215
FT                   /note="PQ-loop 2"
SQ   SEQUENCE   250 AA;  28826 MW;  653DF1578D0E4D1C CRC64;
     MEREGLEWIV AFLRMLVSWG ASCAMIFGGV VPYIPQYRDI RRTQNAEGFS IYVCLMLLIA
     NILRILFWFG HHFESPLLWQ SIIMIVTMLL MLKLCTEVRV ANELNPKRRS FTDFDTAFFW
     HWTRFIDFIQ CVLAFTGVTG YITYLLLDSP LFVEILGFLA VFTEALLGVP QLYRNHQNYS
     TEGMSIKMVL MWTSGDTFKS AYFVLNQAPF QFSICGLLQV FVDIAILLQV YLYSAYPQKP
     VSHATSAKAL