S66A3_HUMAN
ID S66A3_HUMAN Reviewed; 202 AA.
AC Q8N755; B2R8K1; B4DWA4;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Solute carrier family 66 member 3 {ECO:0000305};
DE AltName: Full=PQ-loop repeat-containing protein 3 {ECO:0000305};
DE Flags: Precursor;
GN Name=SLC66A3 {ECO:0000312|HGNC:HGNC:28503};
GN Synonyms=C2orf22, PQLC3 {ECO:0000312|HGNC:HGNC:28503};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Embryo, Stomach, and Synovium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N755-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N755-2; Sequence=VSP_054623;
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DR EMBL; AK001091; BAE46613.1; -; mRNA.
DR EMBL; AK301439; BAG62966.1; -; mRNA.
DR EMBL; AK313402; BAG36198.1; -; mRNA.
DR EMBL; AC018463; AAX93048.1; -; Genomic_DNA.
DR EMBL; CH471053; EAX00939.1; -; Genomic_DNA.
DR EMBL; CH471053; EAX00942.1; -; Genomic_DNA.
DR EMBL; BC027625; AAH27625.1; -; mRNA.
DR CCDS; CCDS1679.1; -. [Q8N755-1]
DR CCDS; CCDS62856.1; -. [Q8N755-2]
DR RefSeq; NP_001269639.1; NM_001282710.1. [Q8N755-2]
DR RefSeq; NP_001269640.1; NM_001282711.1.
DR RefSeq; NP_001269641.1; NM_001282712.1.
DR RefSeq; NP_689604.1; NM_152391.4. [Q8N755-1]
DR AlphaFoldDB; Q8N755; -.
DR BioGRID; 126257; 1.
DR IntAct; Q8N755; 1.
DR MINT; Q8N755; -.
DR STRING; 9606.ENSP00000295083; -.
DR BioMuta; PQLC3; -.
DR DMDM; 74729214; -.
DR EPD; Q8N755; -.
DR jPOST; Q8N755; -.
DR MassIVE; Q8N755; -.
DR MaxQB; Q8N755; -.
DR PaxDb; Q8N755; -.
DR PeptideAtlas; Q8N755; -.
DR PRIDE; Q8N755; -.
DR ProteomicsDB; 5327; -.
DR ProteomicsDB; 72265; -. [Q8N755-1]
DR Antibodypedia; 74460; 31 antibodies from 7 providers.
DR DNASU; 130814; -.
DR Ensembl; ENST00000295083.8; ENSP00000295083.3; ENSG00000162976.13. [Q8N755-1]
DR Ensembl; ENST00000441908.6; ENSP00000406148.2; ENSG00000162976.13. [Q8N755-2]
DR GeneID; 130814; -.
DR KEGG; hsa:130814; -.
DR MANE-Select; ENST00000295083.8; ENSP00000295083.3; NM_152391.5; NP_689604.1.
DR UCSC; uc002rbc.5; human. [Q8N755-1]
DR CTD; 130814; -.
DR DisGeNET; 130814; -.
DR GeneCards; SLC66A3; -.
DR HGNC; HGNC:28503; SLC66A3.
DR HPA; ENSG00000162976; Low tissue specificity.
DR neXtProt; NX_Q8N755; -.
DR OpenTargets; ENSG00000162976; -.
DR PharmGKB; PA134941925; -.
DR VEuPathDB; HostDB:ENSG00000162976; -.
DR eggNOG; KOG3211; Eukaryota.
DR GeneTree; ENSGT00940000153916; -.
DR HOGENOM; CLU_053568_3_2_1; -.
DR InParanoid; Q8N755; -.
DR OMA; YALIYYA; -.
DR OrthoDB; 1059579at2759; -.
DR PhylomeDB; Q8N755; -.
DR TreeFam; TF324895; -.
DR PathwayCommons; Q8N755; -.
DR SignaLink; Q8N755; -.
DR BioGRID-ORCS; 130814; 12 hits in 1074 CRISPR screens.
DR ChiTaRS; PQLC3; human.
DR GenomeRNAi; 130814; -.
DR Pharos; Q8N755; Tdark.
DR PRO; PR:Q8N755; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8N755; protein.
DR Bgee; ENSG00000162976; Expressed in oocyte and 170 other tissues.
DR ExpressionAtlas; Q8N755; baseline and differential.
DR Genevisible; Q8N755; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR016817; MannP-dilichol_defect-1.
DR InterPro; IPR006603; PQ-loop_rpt.
DR PANTHER; PTHR12226; PTHR12226; 1.
DR Pfam; PF04193; PQ-loop; 1.
DR PIRSF; PIRSF023381; MannP-dilichol_defect-1p; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..202
FT /note="Solute carrier family 66 member 3"
FT /id="PRO_0000232512"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 159..172
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054623"
SQ SEQUENCE 202 AA; 22575 MW; 479887EF57BA4DCB CRC64;
MEAALLGLCN WSTLGVCAAL KLPQISAVLA ARSARGLSLP SLLLELAGFL VFLRYQCYYG
YPPLTYLEYP ILIAQDVILL LCIFHFNGNV KQATPYIAVL VSSWFILALQ KWIIDLAMNL
CTFISAASKF AQLQCLWKTR DSGTVSALTW SLSSYTCATR IITTLMTTND FTILLRFVIM
LALNIWVTVT VLRYRKTAIK AE
