S66A3_MOUSE
ID S66A3_MOUSE Reviewed; 202 AA.
AC Q8C6U2; Q8QZS7;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Solute carrier family 66 member 3 {ECO:0000305};
DE AltName: Full=PQ-loop repeat-containing protein 3;
DE Flags: Precursor;
GN Name=Slc66a3; Synonyms=Pqlc3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK053171; BAC35293.1; -; mRNA.
DR EMBL; AK150094; BAE29302.1; -; mRNA.
DR EMBL; BC025220; AAH25220.1; -; mRNA.
DR CCDS; CCDS25824.1; -.
DR RefSeq; NP_766162.2; NM_172574.2.
DR AlphaFoldDB; Q8C6U2; -.
DR BioGRID; 229914; 2.
DR STRING; 10090.ENSMUSP00000054462; -.
DR TCDB; 2.A.43.3.2; the lysosomal cystine transporter (lct) family.
DR EPD; Q8C6U2; -.
DR MaxQB; Q8C6U2; -.
DR PaxDb; Q8C6U2; -.
DR PeptideAtlas; Q8C6U2; -.
DR PRIDE; Q8C6U2; -.
DR ProteomicsDB; 291737; -.
DR Antibodypedia; 74460; 31 antibodies from 7 providers.
DR Ensembl; ENSMUST00000054536; ENSMUSP00000054462; ENSMUSG00000045679.
DR GeneID; 217430; -.
DR KEGG; mmu:217430; -.
DR UCSC; uc007nck.2; mouse.
DR CTD; 217430; -.
DR MGI; MGI:2444067; Pqlc3.
DR VEuPathDB; HostDB:ENSMUSG00000045679; -.
DR eggNOG; KOG3211; Eukaryota.
DR GeneTree; ENSGT00940000153916; -.
DR HOGENOM; CLU_053568_3_2_1; -.
DR InParanoid; Q8C6U2; -.
DR OMA; YALIYYA; -.
DR OrthoDB; 1059579at2759; -.
DR PhylomeDB; Q8C6U2; -.
DR TreeFam; TF324895; -.
DR BioGRID-ORCS; 217430; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Pqlc3; mouse.
DR PRO; PR:Q8C6U2; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8C6U2; protein.
DR Bgee; ENSMUSG00000045679; Expressed in olfactory epithelium and 177 other tissues.
DR ExpressionAtlas; Q8C6U2; baseline and differential.
DR Genevisible; Q8C6U2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR016817; MannP-dilichol_defect-1.
DR InterPro; IPR006603; PQ-loop_rpt.
DR PANTHER; PTHR12226; PTHR12226; 1.
DR Pfam; PF04193; PQ-loop; 1.
DR PIRSF; PIRSF023381; MannP-dilichol_defect-1p; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..202
FT /note="Solute carrier family 66 member 3"
FT /id="PRO_0000232513"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 198
FT /note="A -> V (in Ref. 2; AAH25220)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 202 AA; 22739 MW; 666BDD68E3C89202 CRC64;
MEAGLLWFCN WSTLGVCAAL KLPQIYAQLA ARSARGISLP SLLLELAGFL VFLRYQHYYG
NPLLTYLEYP ILIAQDIVLL LFVFHFNGNV KQALPYMAVF VSSWFILSLQ KWIIDLAMNL
CTVISAASKF AQLQYLWKVQ DSGAVSALTW GLSAYTCATR IITTLMTTND LTILIRFVIM
LALNIWVTAT VLHYRKSATK AE
