S66AL_HUMAN
ID S66AL_HUMAN Reviewed; 135 AA.
AC A1A4F0; C9JP04; C9JXB5; Q8N6Q6;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Putative uncharacterized protein SLC66A1L {ECO:0000305};
DE AltName: Full=PQ-loop repeat-containing protein 2-like {ECO:0000312|HGNC:HGNC:25146};
DE AltName: Full=Solute carrier family 66 member 1-like {ECO:0000305};
GN Name=SLC66A1L {ECO:0000312|HGNC:HGNC:25146};
GN Synonyms=C3orf55 {ECO:0000312|HGNC:HGNC:25146},
GN PQLC2L {ECO:0000312|EMBL:AC084212};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC TISSUE=Brain, and Melanoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC A1A4F0-2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12018000, EBI-16439278;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=A1A4F0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A1A4F0-2; Sequence=VSP_036612;
CC Name=3;
CC IsoId=A1A4F0-3; Sequence=VSP_045571;
CC Name=4;
CC IsoId=A1A4F0-4; Sequence=VSP_046204;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH29129.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
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DR EMBL; AC084212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW78701.1; -; Genomic_DNA.
DR EMBL; BC010062; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC029129; AAH29129.1; ALT_SEQ; mRNA.
DR EMBL; BC126187; AAI26188.1; -; mRNA.
DR EMBL; BC126189; AAI26190.1; -; mRNA.
DR EMBL; BC144066; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001093247.1; NM_001099777.3.
DR RefSeq; NP_001123473.1; NM_001130001.2.
DR RefSeq; NP_001123474.1; NM_001130002.2.
DR RefSeq; NP_001230658.1; NM_001243729.1.
DR AlphaFoldDB; A1A4F0; -.
DR SMR; A1A4F0; -.
DR BioGRID; 127423; 8.
DR IntAct; A1A4F0; 1.
DR STRING; 9606.ENSP00000413228; -.
DR BioMuta; PQLC2L; -.
DR PaxDb; A1A4F0; -.
DR PRIDE; A1A4F0; -.
DR ProteomicsDB; 89; -. [A1A4F0-1]
DR ProteomicsDB; 90; -. [A1A4F0-2]
DR DNASU; 152078; -.
DR GeneID; 152078; -.
DR UCSC; uc003fbo.4; human. [A1A4F0-1]
DR CTD; 152078; -.
DR DisGeNET; 152078; -.
DR GeneCards; SLC66A1L; -.
DR HGNC; HGNC:25146; SLC66A1L.
DR neXtProt; NX_A1A4F0; -.
DR eggNOG; ENOG502S9R0; Eukaryota.
DR HOGENOM; CLU_2721546_0_0_1; -.
DR InParanoid; A1A4F0; -.
DR OrthoDB; 1587758at2759; -.
DR PhylomeDB; A1A4F0; -.
DR PathwayCommons; A1A4F0; -.
DR SignaLink; A1A4F0; -.
DR BioGRID-ORCS; 152078; 6 hits in 1059 CRISPR screens.
DR ChiTaRS; PQLC2L; human.
DR GenomeRNAi; 152078; -.
DR Pharos; A1A4F0; Tdark.
DR PRO; PR:A1A4F0; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; A1A4F0; protein.
DR Genevisible; A1A4F0; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0015174; F:basic amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015189; F:L-lysine transmembrane transporter activity; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..135
FT /note="Putative uncharacterized protein SLC66A1L"
FT /id="PRO_0000301950"
FT VAR_SEQ 72..135
FT /note="IFTAIFDMNTDVIILSQFMYYRLKNQKKKMIFQPQLFKDSITREKVRLSLWG
FT VLCPVYIPYSFR -> F (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045571"
FT VAR_SEQ 72..135
FT /note="IFTAIFDMNTDVIILSQFMYYRLKNQKKKMIFQPQLFKDSITREKVRLSLWG
FT VLCPVYIPYSFR -> DIPTSVIQRLHHQRESQIVTLGSPLPCIYPIFFQISEISMPGY
FT YSCLCHTTINTSKRRFILT (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_046204"
FT VAR_SEQ 101..135
FT /note="MIFQPQLFKDSITREKVRLSLWGVLCPVYIPYSFR -> ISEEDLRKELHFC
FT CLHWP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_036612"
FT VARIANT 4
FT /note="V -> L (in dbSNP:rs7616293)"
FT /id="VAR_050723"
SQ SEQUENCE 135 AA; 15626 MW; E7478D8AA2393875 CRC64;
MKVVGNYRVN TANSSTDTSG EHLTCLRSQL FVAYRNGRVD EAVSLGFLDC WIGGDLTNFK
GCYLTNQLPI QIFTAIFDMN TDVIILSQFM YYRLKNQKKK MIFQPQLFKD SITREKVRLS
LWGVLCPVYI PYSFR
