S6A12_RABIT
ID S6A12_RABIT Reviewed; 614 AA.
AC P48055;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Sodium- and chloride-dependent betaine transporter;
DE AltName: Full=Na(+)/Cl(-) betaine/GABA transporter;
DE AltName: Full=Solute carrier family 6 member 12;
GN Name=SLC6A12;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8779931; DOI=10.1152/ajpcell.1996.270.2.c650;
RA Ferraris J.D., Burg M.B., Williams C.K., Peters E.M., Garcia-Perez A.;
RT "Betaine transporter cDNA cloning and effect of osmolytes on its mRNA
RT induction.";
RL Am. J. Physiol. 270:C650-C654(1996).
CC -!- FUNCTION: Transports betaine and GABA. May have a role in regulation of
CC GABAergic transmission in the brain through the reuptake of GABA into
CC presynaptic terminals, as well as in osmotic regulation (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with LIN7C. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. SLC6A12 subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U26341; AAA67953.1; -; mRNA.
DR RefSeq; NP_001075819.1; NM_001082350.1.
DR AlphaFoldDB; P48055; -.
DR SMR; P48055; -.
DR STRING; 9986.ENSOCUP00000005833; -.
DR PRIDE; P48055; -.
DR GeneID; 100009202; -.
DR KEGG; ocu:100009202; -.
DR CTD; 6539; -.
DR eggNOG; KOG3660; Eukaryota.
DR InParanoid; P48055; -.
DR OrthoDB; 250396at2759; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0005332; F:gamma-aminobutyric acid:sodium symporter activity; IEA:InterPro.
DR GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR002983; Na/ntran_symport_betaine.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; PTHR11616; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR01198; BETTRANSPORT.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SSF161070; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Membrane; Neurotransmitter transport;
KW Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..614
FT /note="Sodium- and chloride-dependent betaine transporter"
FT /id="PRO_0000214790"
FT TOPO_DOM 1..44
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..210
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..229
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..255
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..308
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..341
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..393
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..441
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 499..518
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 538..556
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 557..614
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 574..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 157..166
FT /evidence="ECO:0000250|UniProtKB:Q7K4Y6"
SQ SEQUENCE 614 AA; 69111 MW; 70B175DD218BEEA5 CRC64;
MDTKLAVHED APPLVSWVPE EGEKLEQEGE DQAKDRGQWT NKMEFVLSVA GEIIGLSNVW
RFPYLCYKNG GGAFFVPYFI FFFSCGIPVF FLEVALGQYT SQGSVTAWKK ICPLFQGIGL
ASVVIESYLN VYYIIILAWA LFYLFSSFTS ELPWTTCTNS WNTEYCQHAL NHSGAGIGSS
TENFTSPVME FWERRVLGIT AGIHDLGALR WELALCLLLA WIVCYFCIWK GVKYTGKVVY
FTATFPYLML VILLIRGVTL PGAYQGIVYY LKPDLLRLKD PQVWMDAGTQ IFFSFAICQG
CLTALGSYNK YHNNCYRDSI ALCFLNSATS FVAGFVVFSV LGFMSQEQGV PISEVAESGP
GLAFIAFPKA VTMMPLSQLW SCLFFIMLIF LGLDSQFVCM ECLVTASVDM FPRQLRKSGR
RELLILAIAV LCYLIGLLLV TEGGMYIFQL FDYYACSGIC LLFLSVFEVV SISWVYGADR
FYDNIQDMIG YRPWPLVKIS WLFLTPGLCL ATFLFSLSKY SPLRYNNVYV YPAWGYCVGW
FLAFSSMACV PLCIVIALLK AQGSFTKRLR QLITPDPSLP QPTQQLRLDS GPGQDRRPSP
AKEGLVTVEK ETHL
