S6A15_BOVIN
ID S6A15_BOVIN Reviewed; 729 AA.
AC Q9XS59;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Sodium-dependent neutral amino acid transporter B(0)AT2;
DE AltName: Full=Sodium- and chloride-dependent neurotransmitter transporter NTT73;
DE AltName: Full=Solute carrier family 6 member 15;
DE AltName: Full=Transporter v7-3;
GN Name=SLC6A15; Synonyms=B0AT2, NTT73;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Retina;
RX PubMed=10025945; DOI=10.1016/s0014-5793(98)01733-5;
RA Sakata K., Shimada S., Yamashita T., Inoue K., Tohyama M.;
RT "Cloning of a bovine orphan transporter and its short splicing variant.";
RL FEBS Lett. 443:267-270(1999).
CC -!- FUNCTION: Functions as a sodium-dependent neutral amino acid
CC transporter. Exhibits preference for methionine and for the branched-
CC chain amino acids, particularly leucine, valine and isoleucine.
CC Mediates the saturable, pH-sensitive and electrogenic cotransport of
CC proline and sodium ions with a stoichiometry of 1:1. May have a role as
CC transporter for neurotransmitter precursors into neurons.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. SLC6A15 subfamily. {ECO:0000305}.
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DR EMBL; AB020854; BAA77223.1; -; mRNA.
DR RefSeq; NP_851366.1; NM_181023.2.
DR RefSeq; XP_005206100.1; XM_005206043.2.
DR RefSeq; XP_010803063.1; XM_010804761.2.
DR AlphaFoldDB; Q9XS59; -.
DR SMR; Q9XS59; -.
DR STRING; 9913.ENSBTAP00000024524; -.
DR PaxDb; Q9XS59; -.
DR PRIDE; Q9XS59; -.
DR Ensembl; ENSBTAT00000024524; ENSBTAP00000024524; ENSBTAG00000018432.
DR Ensembl; ENSBTAT00000076418; ENSBTAP00000060813; ENSBTAG00000018432.
DR GeneID; 281952; -.
DR KEGG; bta:281952; -.
DR CTD; 55117; -.
DR VEuPathDB; HostDB:ENSBTAG00000018432; -.
DR VGNC; VGNC:34918; SLC6A15.
DR eggNOG; KOG3659; Eukaryota.
DR GeneTree; ENSGT00940000157277; -.
DR HOGENOM; CLU_006855_7_1_1; -.
DR InParanoid; Q9XS59; -.
DR OMA; VVFCLRY; -.
DR OrthoDB; 250396at2759; -.
DR TreeFam; TF352709; -.
DR Reactome; R-BTA-352230; Amino acid transport across the plasma membrane.
DR Reactome; R-BTA-442660; Na+/Cl- dependent neurotransmitter transporters.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000018432; Expressed in occipital lobe and 57 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005298; F:proline:sodium symporter activity; ISS:UniProtKB.
DR GO; GO:0015820; P:leucine transport; ISS:UniProtKB.
DR GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR GO; GO:0015824; P:proline transport; ISS:UniProtKB.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR CDD; cd11522; SLC6sbd_SBAT1; 1.
DR InterPro; IPR042934; B(0)AT2.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR002438; Neutral_aa_SLC6.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; PTHR11616; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR PRINTS; PR01206; ORPHTRNSPORT.
DR SUPFAM; SSF161070; SSF161070; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Glycoprotein; Ion transport; Membrane;
KW Neurotransmitter transport; Phosphoprotein; Reference proteome; Sodium;
KW Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..729
FT /note="Sodium-dependent neutral amino acid transporter
FT B(0)AT2"
FT /id="PRO_0000214797"
FT TOPO_DOM 1..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..117
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..225
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..244
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..270
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..323
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..356
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357..452
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..472
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 496..514
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 530..550
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 571..592
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 620..642
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 643..729
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 25
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H2J7"
FT MOD_RES 55
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H2J7"
FT MOD_RES 687
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H2J7"
FT MOD_RES 699
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H2J7"
FT MOD_RES 701
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H2J7"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 383
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 394
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 729 AA; 81681 MW; 332FD83349C196A9 CRC64;
MPKNSKVVKR ELDDEVIESV KDLLSNEDSA DDAFKKSELI VDVPEEKDTD VVERSEVKDA
RPAWNSKLQY ILAQVGFSVG LGNVWRFPYL CQKNGGGAYL LPYLILLLVI GIPLFFLELS
VGQRIRRGSI GVWNYISPQL GGIGFASCVV CFFVALYYNV IIGWSLFYFS QSFQQPLPWD
QCPLVKNASH TFVEPECEKS SATTYYWYRE ALNISTSISE SGGLNWKMTI CLLAAWVVVC
LAMIKGIQSS GKIMYFSSLF PYVVLICFLI RALLLNGSVD GIRHMFTPEL EIMLEPKVWR
EAAAQVFFAL GLGFGGVIAF SSYNKRDNNC HFDAVLVSFI NFFTSILATL VVFAVLGFKA
NVINEKCIAE NSEMIIKLVK MGNISQDIIP HHINFSAITA EDYDLIYDII QKVKEEEFPA
LHLNACQIED ELNKAVQGTG LAFIAFTEAM THFPASPFWS VMFFLMLVNL GLGSMFGTIE
GIITPVVDTF KVRKEILTVI CCLLAFCIGL IFVQRSGNYF VTMFDDYSAT LPLLIVVILE
NIAVSFVYGI DKFMEDLKDM LGFTPNRYYY YMWKYISPLM LLSLLIASIV NMGLSPPGYN
AWMEDKASEK FLSYPTWGMV ICISLMVLAI LPIPVVFIIR RCNLIDDSSG NLASVTYKRG
RVLKEPVNLE GDDASLIHGK ISSEMSSPNF GKNIYRKQSG SPTLDTAPNG RYGIGYLMAD
MPDMPESDL
