S6A15_PONAB
ID S6A15_PONAB Reviewed; 730 AA.
AC Q5R9C2;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 2.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Sodium-dependent neutral amino acid transporter B(0)AT2;
DE AltName: Full=Sodium- and chloride-dependent neurotransmitter transporter NTT73;
DE AltName: Full=Solute carrier family 6 member 15;
DE AltName: Full=Transporter v7-3;
GN Name=SLC6A15; Synonyms=B0AT2;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sodium-dependent neutral amino acid
CC transporter. Exhibits preference for methionine and for the branched-
CC chain amino acids, particularly leucine, valine and isoleucine.
CC Mediates the saturable, pH-sensitive and electrogenic cotransport of
CC proline and sodium ions with a stoichiometry of 1:1. May have a role as
CC transporter for neurotransmitter precursors into neurons. In contrast
CC to other members of the neurotransmitter transporter family, does not
CC appear to be chloride-dependent (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. SLC6A15 subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAH91638.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CR859467; CAH91638.1; ALT_INIT; mRNA.
DR RefSeq; NP_001127446.1; NM_001133974.1.
DR AlphaFoldDB; Q5R9C2; -.
DR SMR; Q5R9C2; -.
DR STRING; 9601.ENSPPYP00000005482; -.
DR GeneID; 100174517; -.
DR KEGG; pon:100174517; -.
DR CTD; 55117; -.
DR eggNOG; KOG3659; Eukaryota.
DR InParanoid; Q5R9C2; -.
DR OrthoDB; 250396at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0005298; F:proline:sodium symporter activity; ISS:UniProtKB.
DR GO; GO:0015820; P:leucine transport; ISS:UniProtKB.
DR GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR GO; GO:0015824; P:proline transport; ISS:UniProtKB.
DR CDD; cd11522; SLC6sbd_SBAT1; 1.
DR InterPro; IPR042934; B(0)AT2.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR002438; Neutral_aa_SLC6.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; PTHR11616; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR PRINTS; PR01206; ORPHTRNSPORT.
DR SUPFAM; SSF161070; SSF161070; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Glycoprotein; Ion transport; Membrane;
KW Neurotransmitter transport; Phosphoprotein; Reference proteome; Sodium;
KW Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..730
FT /note="Sodium-dependent neutral amino acid transporter
FT B(0)AT2"
FT /id="PRO_0000406988"
FT TOPO_DOM 1..70
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..223
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 356..458
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 459..479
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 494..514
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 530..550
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 575..595
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 619..639
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 640..730
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 25
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H2J7"
FT MOD_RES 55
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H2J7"
FT MOD_RES 687
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H2J7"
FT MOD_RES 699
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H2J7"
FT MOD_RES 701
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H2J7"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 730 AA; 81708 MW; 0E219EFFE2263D89 CRC64;
MPKNSKVVKR ELDDDVTESV KDLLSNEDSA DDAFKTSELI VDGQEEKDTD VEEGSEVEDE
RPAWSSKLQY ILAQVGFSVG LGNVWRFPYL CQKNGGGAYL LPYLILLMVI GIPLFFLELS
VGQRIRRGSI GVWNYISPKL GGIGFASCVV CYFVALYYNV IIGWSLFYFS QSFQQPLPWD
QCPLVKNASH TFVEPECEQS SATTYYWYRE ALNISSSISE SGGLNWKMTI CLLAAWVMVC
LAMIKGIQSS GKIIYFSSLF PYVVLICFLI RALLLNGSID GIRHMFTPKL EIMLEPKVWR
EAATQVFFAL GLGFGGVIAF SSYNKRDNNC HFDAVLVSFI NFFTSVLATL VVFAVLGFKA
NVINEKCITQ NSQTIMKFLK MGNISQDIIP HHINLSAVTA EDYHLVYDII QKVKEEEFPA
LHLNSCKIEE ELNKAVQGTG LAFIAFTEAM THFPASPFWS VMFFLMLVNL GLGSMFGTIE
GIVTPIVDTF KVRKEILTVI CCLLAFCIGL IFVQRSGNYF VTMFDDYSAT LPLLIVVILE
NIAVCFVYGI DKFMEDLKDM LGFAPSRYYY YMWKYVSPLM LLSLLIASVV NMGLSPPGYN
AWIEDKASEE FLSYPTWGLV VCVSLVVFAV LPVPVVFIVR RFNLIDDSSG NLASVTYKRG
RVLNEPVNLE GDDTSLIHGK ISSEMPSPNF GKNIYRKQSG SPTLDTAPNG RYGIGYLMAD
IMPDMPESDL
