S7A13_RAT
ID S7A13_RAT Reviewed; 479 AA.
AC Q5RKI7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Solute carrier family 7 member 13;
DE AltName: Full=Sodium-independent aspartate/glutamate transporter 1;
GN Name=Slc7a13;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mediates the transport L-aspartate and L-glutamate in a
CC sodium-independent manner. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. {ECO:0000305}.
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DR EMBL; BC085796; AAH85796.1; -; mRNA.
DR RefSeq; NP_001012100.1; NM_001012100.1.
DR AlphaFoldDB; Q5RKI7; -.
DR SMR; Q5RKI7; -.
DR STRING; 10116.ENSRNOP00000032751; -.
DR iPTMnet; Q5RKI7; -.
DR PhosphoSitePlus; Q5RKI7; -.
DR PaxDb; Q5RKI7; -.
DR Ensembl; ENSRNOT00000035685; ENSRNOP00000032751; ENSRNOG00000024903.
DR GeneID; 313089; -.
DR KEGG; rno:313089; -.
DR UCSC; RGD:1311633; rat.
DR CTD; 157724; -.
DR RGD; 1311633; Slc7a13.
DR eggNOG; KOG1287; Eukaryota.
DR GeneTree; ENSGT00940000162798; -.
DR HOGENOM; CLU_007946_3_0_1; -.
DR InParanoid; Q5RKI7; -.
DR OMA; SPNVHYV; -.
DR OrthoDB; 621852at2759; -.
DR PhylomeDB; Q5RKI7; -.
DR TreeFam; TF313355; -.
DR PRO; PR:Q5RKI7; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000024903; Expressed in kidney and 9 other tissues.
DR Genevisible; Q5RKI7; RN.
DR GO; GO:0016324; C:apical plasma membrane; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; ISO:RGD.
DR GO; GO:0015810; P:aspartate transmembrane transport; ISO:RGD.
DR GO; GO:0015811; P:L-cystine transport; ISO:RGD.
DR GO; GO:0015813; P:L-glutamate transmembrane transport; ISO:RGD.
DR InterPro; IPR002293; AA/rel_permease1.
DR Pfam; PF13520; AA_permease_2; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..479
FT /note="Solute carrier family 7 member 13"
FT /id="PRO_0000330727"
FT TOPO_DOM 1..14
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..89
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..129
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..208
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..289
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..338
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 382..396
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 418..423
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 445..479
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 479 AA; 53551 MW; 9EDA418E533B2B96 CRC64;
MAMDIEKKIY LKRQLGYFWG TNFLIINIIG AGIFVSPKGV LQYSSMNVGV SLCVWVFCAV
LSMTSTLCAA EIGITFPYTV AHYYFLKRCF GPFVAFLRLW TSLFTGPGVL ASQALLLAEY
GIQPFYPSCS APAVPKKCLA LAMLWIVGIL NSRGVKELSW LQTVSMVLKM GILSFISLSG
LFLLVTGRKE NVRRLQNAFD AEFPEVSRLI EAIFQGYFAF SGGGSFTYVA GELKEPSKTI
PRCIFTALPL VTVVYLLANL SYLTVLSPQE LLSSDAVALT WTDRVIPQLT WSVPFAISAS
LFSNLVTSVF ETSRTSYIAS RNGQLPLLCS TLNVHSSPFI AVLLDVSMGS IAIVLTNLIE
LINYLFFVFS IWTVLSVIGI LKLRYQEPNL HRPYKVFSPF LFITAAISLS MVLIPLIKSP
KMQYIYVFLF FLGGLLFYVP LIHFKLKLIW FQKLTCYLQL LFNICIPDVS DEHVAEEES
