ID   S7A14_BOVIN             Reviewed;         771 AA.
AC   A0JNI9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Probable cationic amino acid transporter;
DE   AltName: Full=Solute carrier family 7 member 14;
GN   Name=SLC7A14;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC126705; AAI26706.1; -; mRNA.
DR   RefSeq; NP_001071460.1; NM_001077992.2.
DR   AlphaFoldDB; A0JNI9; -.
DR   SMR; A0JNI9; -.
DR   STRING; 9913.ENSBTAP00000031960; -.
DR   PaxDb; A0JNI9; -.
DR   Ensembl; ENSBTAT00000032016; ENSBTAP00000031960; ENSBTAG00000016323.
DR   GeneID; 533046; -.
DR   KEGG; bta:533046; -.
DR   CTD; 57709; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016323; -.
DR   VGNC; VGNC:34927; SLC7A14.
DR   eggNOG; KOG1286; Eukaryota.
DR   GeneTree; ENSGT00940000155893; -.
DR   HOGENOM; CLU_007946_15_7_1; -.
DR   InParanoid; A0JNI9; -.
DR   OMA; KEACSPG; -.
DR   OrthoDB; 439017at2759; -.
DR   TreeFam; TF315212; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000016323; Expressed in occipital lobe and 17 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   InterPro; IPR029485; CAT_C.
DR   Pfam; PF13520; AA_permease_2; 1.
DR   Pfam; PF13906; AA_permease_C; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Glycoprotein; Membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..771
FT                   /note="Probable cationic amino acid transporter"
FT                   /id="PRO_0000307359"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        336..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        565..585
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        596..616
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        628..648
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        655..675
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          712..771
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        731..745
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         465
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BXR1"
FT   MOD_RES         468
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BXR1"
FT   MOD_RES         488
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BXR1"
FT   MOD_RES         757
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BXR1"
FT   MOD_RES         769
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BXR1"
FT   CARBOHYD        282
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        676
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   771 AA;  84188 MW;  68B284D73ECD5B22 CRC64;
     MSGFLTSLDP RRVQWGAAWY AMHSRILRTK PVESMLEGTG ATTAHGTKLA QVLTTMDLIS
     LGVGSCVGTG MYVVSGLVAK EMAGPGVIVS FIIAAVASIL SGVCYAEFGV RVPKTTGSAY
     TYSYVTVGEF VAFFIGWNLI LEYLIGTAAG ASALSSMFDS LANHTISRWM VDSVGTLNGL
     GKGEQSYPDL LALVIAIIVT IIVALGVKNS VGFNNVLNVL NLAVWVFIMI AGFFFINGKY
     WAEGQFLPYG WSGVLQGAAT CFYAFIGFDI IATTGEEAKN PNTSIPYAIT ASLVICLTAY
     VSVSMILTLM VPYDTIDTES PLMEMFVARG FYAAKFVVAI GSVAGLTVSL LGSLFPMPRV
     IYAMAGDGLL FRFLAHVSSY TETPVVACIV SGFLAALLSL LVSLRDLIEM MSIGTLLAYT
     LVSVCVLLLR YQPESDIDGF VKFLSEEHTK KKEGILADCE KEVCSPVSEG EEFSGPATNT
     CGAKNLPSLG DNEMLIGKSD KSTYNVNHPN YGTVDMTTGI EADESENIYL IKLKKLIGPR
     YYTMRIQLGL PGKMDRPTAA TGHTVTICVL LLFILMFVFC SFIIFGSDYI SEQSWWAILL
     VVLMVLLISA LVFVILQQPE NPKKLPYMAP CLPFVPAFAM LVNIYLMLKL STITWIRFAV
     WCFVGMLIYF GYGIWNSTLE ISAREEALHQ STYQRYDVDD PFSVEEGFSY ATEGESQENW
     GGPAEDKGFY YQQMSDTQPN TRTSSKAKSK SKHKQNSEAL IANDELDYSP E