S7A14_DANRE
ID S7A14_DANRE Reviewed; 785 AA.
AC B0UYF2;
DT 03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Probable cationic amino acid transporter;
DE AltName: Full=Solute carrier family 7 member 14;
GN Name=slc7a14a;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP DISRUPTION PHENOTYPE.
RX PubMed=24670872; DOI=10.1038/ncomms4517;
RA Jin Z.B., Huang X.F., Lv J.N., Xiang L., Li D.Q., Chen J., Huang C., Wu J.,
RA Lu F., Qu J.;
RT "SLC7A14 linked to autosomal recessive retinitis pigmentosa.";
RL Nat. Commun. 5:3517-3517(2014).
CC -!- FUNCTION: May be involved in arginine transport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes
CC smaller eyes compared to wild-type animals and aberrant light-induced
CC locomotor response. {ECO:0000269|PubMed:24670872}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. {ECO:0000305}.
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DR EMBL; CR392026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR450771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001334618.1; NM_001347689.1.
DR RefSeq; XP_694632.2; XM_689540.5.
DR AlphaFoldDB; B0UYF2; -.
DR SMR; B0UYF2; -.
DR STRING; 7955.ENSDARP00000038463; -.
DR PaxDb; B0UYF2; -.
DR Ensembl; ENSDART00000137746; ENSDARP00000115765; ENSDARG00000010816.
DR Ensembl; ENSDART00000178841; ENSDARP00000144454; ENSDARG00000010816.
DR Ensembl; ENSDART00000187743; ENSDARP00000149405; ENSDARG00000010816.
DR GeneID; 566270; -.
DR KEGG; dre:566270; -.
DR CTD; 566270; -.
DR ZFIN; ZDB-GENE-070912-112; slc7a14a.
DR eggNOG; KOG1286; Eukaryota.
DR GeneTree; ENSGT00940000155893; -.
DR HOGENOM; CLU_007946_15_7_1; -.
DR InParanoid; B0UYF2; -.
DR OMA; KEACSPG; -.
DR OrthoDB; 439017at2759; -.
DR PhylomeDB; B0UYF2; -.
DR TreeFam; TF315212; -.
DR PRO; PR:B0UYF2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 2.
DR Bgee; ENSDARG00000010816; Expressed in brain and 14 other tissues.
DR ExpressionAtlas; B0UYF2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR GO; GO:0001654; P:eye development; IMP:ZFIN.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR029485; CAT_C.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
PE 3: Inferred from homology;
KW Lysosome; Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..785
FT /note="Probable cationic amino acid transporter"
FT /id="PRO_0000429971"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 568..588
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 596..616
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 628..648
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 655..675
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 715..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 785 AA; 84887 MW; 46DC9CF11A66F062 CRC64;
MSGLFAKLDP RRVQWGANWF AFRSRVLRTK PVESMLETSG GTGAHGTKLA RVLSTVDLVS
LGVGSCVGTG MYVVSGLVAK EMAGPGVIVS FIIAAVASIL SGVCYAEFGV RVPKTTGSAY
TYSYVTVGEF VAFFIGWNLI LEYLIGTAAG ASALSSMFDS LANHSISGFM INHIGTLNGL
GKGEQSYPDI LALVIGILVT VIVALGVKNS VGFNNVLNVI NLVVWVFIMI AGLFFVSGSN
WDEGRFLPYG WSGVMQGAAT CFYAFIGFDI IATTGEEAKS PNTSIPYAIT ASLVTCLTAY
VSVSVILTLM VPYTEIDSDA PLMEMFSLHG FQTAKYIVAI GSIAGLTVSL LGSLFPMPRV
IYAMAGDGLL FRFLAHVSTY TETPAVACVV SGFLSALLAL LVSLRDLIEM MSIGTLLAYT
LVSVCVLLLR YQPEGDIHGF VNFLSEQNSK RKEGVLAECE KEACSPVSEG DDYGGVPTNT
CGAKNLPSLG DNEMLIGKPD KSTYTASHPN YGTVDMSSGI ESDETDSAYL LKLKKLLGPR
YYTMRIRLGL PGKMDRPTVA TGRIVTRCVV LLFILIFCFC SLIIFGSGQI ADGQWWAVLL
LVVLLLVLTL LVFIIIQQPE NPKRLPYMAP CVPFVPASAM LVNVYLMLKL STITWIRFGV
WCFVGVLIYF GYGMWNSTLE ITAREEEAHA STYQRYDMGV DDNFAVDDDL YPSGDQGPFQ
NWGKGGQQKQ PQQEQSEPQS DGLDRLDNHR TSSSSSHSRA KSKASKPSPG FEALVVDDDL
DDPLE
