ID   S7A6O_DANRE             Reviewed;         326 AA.
AC   Q5U3I2; Q59I65;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Probable RNA polymerase II nuclear localization protein SLC7A6OS;
DE   AltName: Full=Solute carrier family 7 member 6 opposite strand transcript homolog;
GN   Name=slc7a6os; ORFNames=zgc:103493;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX   PubMed=15753045; DOI=10.1016/j.cub.2005.02.018;
RA   Kawakami A., Nojima Y., Toyoda A., Takahoko M., Satoh M., Tanaka H.,
RA   Wada H., Masai I., Terasaki H., Sakaki Y., Takeda H., Okamoto H.;
RT   "The zebrafish-secreted matrix protein You/Scube2 is implicated in long-
RT   range regulation of hedgehog signaling.";
RL   Curr. Biol. 15:480-488(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Directs RNA polymerase II nuclear import. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5U3I2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5U3I2-2; Sequence=VSP_025948, VSP_025949;
CC   -!- SIMILARITY: Belongs to the IWR1/SLC7A6OS family. {ECO:0000305}.
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DR   EMBL; AB193555; BAD91396.1; -; mRNA.
DR   EMBL; BC085534; AAH85534.1; -; mRNA.
DR   AlphaFoldDB; Q5U3I2; -.
DR   SMR; Q5U3I2; -.
DR   STRING; 7955.ENSDARP00000020840; -.
DR   PaxDb; Q5U3I2; -.
DR   ZFIN; ZDB-GENE-041114-32; slc7a6os.
DR   eggNOG; KOG4852; Eukaryota.
DR   InParanoid; Q5U3I2; -.
DR   PhylomeDB; Q5U3I2; -.
DR   PRO; PR:Q5U3I2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007417; P:central nervous system development; IMP:ZFIN.
DR   GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR   GO; GO:0021552; P:midbrain-hindbrain boundary structural organization; IMP:ZFIN.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0061053; P:somite development; IMP:ZFIN.
DR   InterPro; IPR040218; SLC7A6OS.
DR   InterPro; IPR013883; TF_Iwr1_dom.
DR   PANTHER; PTHR31196; PTHR31196; 1.
DR   Pfam; PF08574; Iwr1; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Nucleus; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..326
FT                   /note="Probable RNA polymerase II nuclear localization
FT                   protein SLC7A6OS"
FT                   /id="PRO_0000289171"
FT   REGION          30..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          120..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          252..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          307..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        262..297
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..326
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..64
FT                   /note="MDPSTTILRVKRKRGTDPADALLLACKRIRPEATAAQPSDESEPEPQEPKIE
FT                   NSVFKLVATVVS -> MTNKMSCMLIVTDIIISSSVVLFNFHWLLQSYFGQLPL (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15753045"
FT                   /id="VSP_025948"
FT   VAR_SEQ         131
FT                   /note="A -> AGG (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15753045"
FT                   /id="VSP_025949"
FT   CONFLICT        143
FT                   /note="A -> T (in Ref. 1; BAD91396)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        277
FT                   /note="S -> G (in Ref. 1; BAD91396)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        298
FT                   /note="R -> W (in Ref. 1; BAD91396)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   326 AA;  37039 MW;  565550271C252622 CRC64;
     MDPSTTILRV KRKRGTDPAD ALLLACKRIR PEATAAQPSD ESEPEPQEPK IENSVFKLVA
     TVVSQDAPVQ PHVREALARP RLAHHALRPS QGSSQRIIGD LRSVKWSTRR EERYRILSSH
     RAGLPSEPAP AGGGGEENHD SHAESRDGLP LGEVQVFDIL HEEEDVKVPG KMVVSDPETI
     LCNSVKMIRE KLSVSGAGLG TEHREKEDDY VYDLYYQETA TPGWIQDILS VRPYSQEGEL
     VPDEVAWEEE VYEDEDDENA EANWRNDYPE ESSEGDSEGE ERYGGCWSEE HSYSRRSREC
     YRRDMIDELE NDKDEDDEER EYNDSD