S7A6O_MOUSE
ID S7A6O_MOUSE Reviewed; 306 AA.
AC Q7TPE5;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Probable RNA polymerase II nuclear localization protein SLC7A6OS;
DE AltName: Full=Solute carrier family 7 member 6 opposite strand transcript homolog;
GN Name=Slc7a6os;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=ICR; TISSUE=Trophoblast stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299 AND SER-305, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Directs RNA polymerase II nuclear import. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IWR1/SLC7A6OS family. {ECO:0000305}.
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DR EMBL; AK146733; BAE27395.1; -; mRNA.
DR EMBL; BC054118; AAH54118.1; -; mRNA.
DR CCDS; CCDS22632.1; -.
DR RefSeq; NP_001007568.1; NM_001007567.2.
DR AlphaFoldDB; Q7TPE5; -.
DR IntAct; Q7TPE5; 1.
DR MINT; Q7TPE5; -.
DR STRING; 10090.ENSMUSP00000039029; -.
DR iPTMnet; Q7TPE5; -.
DR PhosphoSitePlus; Q7TPE5; -.
DR EPD; Q7TPE5; -.
DR jPOST; Q7TPE5; -.
DR MaxQB; Q7TPE5; -.
DR PaxDb; Q7TPE5; -.
DR PeptideAtlas; Q7TPE5; -.
DR PRIDE; Q7TPE5; -.
DR ProteomicsDB; 255450; -.
DR Antibodypedia; 50485; 17 antibodies from 10 providers.
DR DNASU; 66432; -.
DR Ensembl; ENSMUST00000035925; ENSMUSP00000039029; ENSMUSG00000033106.
DR GeneID; 66432; -.
DR KEGG; mmu:66432; -.
DR UCSC; uc009nfp.2; mouse.
DR CTD; 84138; -.
DR MGI; MGI:1916951; Slc7a6os.
DR VEuPathDB; HostDB:ENSMUSG00000033106; -.
DR eggNOG; KOG4852; Eukaryota.
DR GeneTree; ENSGT00390000015672; -.
DR HOGENOM; CLU_059743_0_0_1; -.
DR InParanoid; Q7TPE5; -.
DR OMA; YPDEDEF; -.
DR OrthoDB; 1160014at2759; -.
DR PhylomeDB; Q7TPE5; -.
DR TreeFam; TF324404; -.
DR BioGRID-ORCS; 66432; 27 hits in 72 CRISPR screens.
DR ChiTaRS; Slc7a6os; mouse.
DR PRO; PR:Q7TPE5; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q7TPE5; protein.
DR Bgee; ENSMUSG00000033106; Expressed in animal zygote and 214 other tissues.
DR Genevisible; Q7TPE5; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR040218; SLC7A6OS.
DR InterPro; IPR013883; TF_Iwr1_dom.
DR PANTHER; PTHR31196; PTHR31196; 1.
DR Pfam; PF08574; Iwr1; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Phosphoprotein; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..306
FT /note="Probable RNA polymerase II nuclear localization
FT protein SLC7A6OS"
FT /id="PRO_0000289170"
FT REGION 30..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 299
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 305
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
SQ SEQUENCE 306 AA; 35041 MW; B7818376BB37589D CRC64;
MEAGRTAVLR VKRKRNAEPA EALVLACKRP RSSEVESAAR ETPEGQEAAA AERNVFQLVA
TVRSQEEPIQ QLVRAALRPS RSSQLRIRRD LRASVREVRK EGRYRVVSSH RSSGTSNSLE
PQCGSEAVGD AGFQLLDLVH EEENPEAAAT DCRKTSDPDV ILCNSVELIR ERLTVSEDGS
QVNHQEDPKH NDDYVYDIYY MEMAPPGWIE NIMSVQPYSQ EWELVNDDEQ SEDIYEDEDD
ENSENNWRNE YPDEESSDRD EDSRGSDEYN SLSEEERSCE RLMWSKYPLD VQKEFDYDSP
HGLDSD
