SAA1_MOUSE
ID SAA1_MOUSE Reviewed; 122 AA.
AC P05366;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Serum amyloid A-1 protein;
DE Flags: Precursor;
GN Name=Saa1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3013853; DOI=10.1016/s0021-9258(19)83932-7;
RA Lowell C.A., Potter D.A., Stearman R.S., Morrow J.F.;
RT "Structure of the murine serum amyloid A gene family. Gene conversion.";
RL J. Biol. Chem. 261:8442-8452(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE OF 9-122, TISSUE SPECIFICITY, AND INDUCTION BY
RP LIPOPOLYSACCHARIDE.
RX PubMed=3857624; DOI=10.1073/pnas.82.9.2915;
RA Yamamoto K., Migita S.;
RT "Complete primary structures of two major murine serum amyloid A proteins
RT deduced from cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 82:2915-2919(1985).
RN [3]
RP PROTEIN SEQUENCE OF 20-39, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP FUNCTION.
RX PubMed=9518179; DOI=10.1016/s0378-4347(97)00462-3;
RA Kaplan B., Yakar S., Balta Y., Pras M., Martin B.;
RT "Isolation and purification of two major serum amyloid A isotypes SAA1 and
RT SAA2 from the acute phase plasma of mice.";
RL J. Chromatogr. B 704:69-76(1997).
CC -!- FUNCTION: Major acute phase protein. {ECO:0000269|PubMed:9518179}.
CC -!- SUBUNIT: Homohexamer; dimer of trimers. Can form amyloid fibrils after
CC partial proteolysis; the native, undenatured protein does not form
CC amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to
CC heparin (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9518179}.
CC -!- TISSUE SPECIFICITY: Detected in blood plasma (at protein level).
CC Detected in liver. {ECO:0000269|PubMed:3857624,
CC ECO:0000269|PubMed:9518179}.
CC -!- INDUCTION: By bacterial lipopolysaccharide.
CC {ECO:0000269|PubMed:3857624}.
CC -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
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DR EMBL; M13521; AAA40084.1; -; Genomic_DNA.
DR EMBL; M11131; AAA40083.1; -; Genomic_RNA.
DR CCDS; CCDS21284.1; -.
DR PIR; A23843; A23843.
DR RefSeq; NP_033143.1; NM_009117.3.
DR RefSeq; XP_006540789.1; XM_006540726.3.
DR AlphaFoldDB; P05366; -.
DR SMR; P05366; -.
DR STRING; 10090.ENSMUSP00000119150; -.
DR iPTMnet; P05366; -.
DR PhosphoSitePlus; P05366; -.
DR CPTAC; non-CPTAC-3437; -.
DR PaxDb; P05366; -.
DR PeptideAtlas; P05366; -.
DR PRIDE; P05366; -.
DR ProteomicsDB; 260809; -.
DR DNASU; 20208; -.
DR Ensembl; ENSMUST00000128088; ENSMUSP00000119150; ENSMUSG00000074115.
DR GeneID; 20208; -.
DR KEGG; mmu:20208; -.
DR UCSC; uc009gyz.1; mouse.
DR CTD; 6288; -.
DR MGI; MGI:98221; Saa1.
DR VEuPathDB; HostDB:ENSMUSG00000074115; -.
DR eggNOG; ENOG502S4PB; Eukaryota.
DR GeneTree; ENSGT00390000004737; -.
DR HOGENOM; CLU_129936_0_0_1; -.
DR InParanoid; P05366; -.
DR OMA; HEDTIAD; -.
DR OrthoDB; 1417043at2759; -.
DR PhylomeDB; P05366; -.
DR TreeFam; TF332544; -.
DR BioGRID-ORCS; 20208; 1 hit in 53 CRISPR screens.
DR ChiTaRS; Saa1; mouse.
DR PRO; PR:P05366; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P05366; protein.
DR Bgee; ENSMUSG00000074115; Expressed in left colon and 53 other tissues.
DR ExpressionAtlas; P05366; baseline and differential.
DR Genevisible; P05366; MM.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR GO; GO:0008203; P:cholesterol metabolic process; IDA:MGI.
DR GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR InterPro; IPR000096; Serum_amyloid_A.
DR Pfam; PF00277; SAA; 1.
DR PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR PRINTS; PR00306; SERUMAMYLOID.
DR SMART; SM00197; SAA; 1.
DR PROSITE; PS00992; SAA; 1.
PE 1: Evidence at protein level;
KW Acute phase; Direct protein sequencing; HDL; Heparin-binding;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000269|PubMed:9518179"
FT CHAIN 20..122
FT /note="Serum amyloid A-1 protein"
FT /id="PRO_0000031588"
FT REGION 20..45
FT /note="Important for amyloid formation"
FT /evidence="ECO:0000250"
FT REGION 91..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 122 AA; 13770 MW; 0AEF6D5F208EA4D0 CRC64;
MKLLTSLVFC SLLLGVCHGG FFSFVHEAFQ GAGDMWRAYT DMKEANWKNS DKYFHARGNY
DAAQRGPGGV WAAEKISDGR EAFQEFFGRG HEDTIADQEA NRHGRSGKDP NYYRPPGLPD
KY
