ID   SAA2_MESAU              Reviewed;         122 AA.
AC   P20727;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Serum amyloid A-2 protein;
DE   Contains:
DE     RecName: Full=Amyloid protein AA1 {ECO:0000250|UniProtKB:P02739};
DE     AltName: Full=Protein AA1 {ECO:0000250|UniProtKB:P02739};
DE              Short=AA1 {ECO:0000250|UniProtKB:P02739};
DE   Contains:
DE     RecName: Full=Amyloid protein AA2 {ECO:0000250|UniProtKB:P02739};
DE     AltName: Full=Protein AA2 {ECO:0000250|UniProtKB:P02739};
DE              Short=AA2 {ECO:0000250|UniProtKB:P02739};
DE   Flags: Precursor;
GN   Name=SAA2;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=2765510; DOI=10.1021/bi00437a040;
RA   Webb C.F., Tucker P.W., Dowton S.B.;
RT   "Expression and sequence analyses of serum amyloid A in the Syrian
RT   hamster.";
RL   Biochemistry 28:4785-4790(1989).
CC   -!- FUNCTION: Major acute phase reactant. {ECO:0000250|UniProtKB:P05366}.
CC   -!- SUBUNIT: Apolipoprotein of the HDL complex.
CC       {ECO:0000250|UniProtKB:P0DJI8}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0DJI8}.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
CC       {ECO:0000269|PubMed:2765510}.
CC   -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
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DR   EMBL; M27243; AAA37096.1; ALT_SEQ; mRNA.
DR   PIR; C30248; C30248.
DR   AlphaFoldDB; P20727; -.
DR   SMR; P20727; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR000096; Serum_amyloid_A.
DR   Pfam; PF00277; SAA; 1.
DR   PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR   PRINTS; PR00306; SERUMAMYLOID.
DR   SMART; SM00197; SAA; 1.
DR   PROSITE; PS00992; SAA; 1.
PE   2: Evidence at transcript level;
KW   Acute phase; Amyloid; HDL; Pyrrolidone carboxylic acid; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250|UniProtKB:P02739"
FT   CHAIN           19..122
FT                   /note="Serum amyloid A-2 protein"
FT                   /id="PRO_0000031586"
FT   CHAIN           19..83
FT                   /note="Amyloid protein AA1"
FT                   /evidence="ECO:0000250|UniProtKB:P02739"
FT                   /id="PRO_0000450360"
FT   CHAIN           19..72
FT                   /note="Amyloid protein AA2"
FT                   /evidence="ECO:0000250|UniProtKB:P02739"
FT                   /id="PRO_0000450361"
FT   REGION          100..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         19
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P02739"
SQ   SEQUENCE   122 AA;  14110 MW;  D99EC964B1C4C22F CRC64;
     MKPFLSIIFC FLVLGVDSQR WFQFMKEAGQ GTRDMWRAYT DMREANWKNS DKYFHARGNY
     DAAQRGPGGA WAAKVISDAR EGFKRMRGRG IEDSRADQFA NEWGRSGKDP NFFRPPGLPS
     KY