ID   SAA2_MOUSE              Reviewed;         122 AA.
AC   P05367;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   03-AUG-2022, entry version 159.
DE   RecName: Full=Serum amyloid A-2 protein {ECO:0000305};
DE   Contains:
DE     RecName: Full=Amyloid protein A {ECO:0000250|UniProtKB:P02739};
DE   Flags: Precursor;
GN   Name=Saa2 {ECO:0000312|MGI:MGI:98222};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=3013853; DOI=10.1016/s0021-9258(19)83932-7;
RA   Lowell C.A., Potter D.A., Stearman R.S., Morrow J.F.;
RT   "Structure of the murine serum amyloid A gene family. Gene conversion.";
RL   J. Biol. Chem. 261:8442-8452(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3857624; DOI=10.1073/pnas.82.9.2915;
RA   Yamamoto K., Migita S.;
RT   "Complete primary structures of two major murine serum amyloid A proteins
RT   deduced from cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:2915-2919(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-122.
RX   PubMed=3624868;
RA   Yamamoto K., Goto N., Kosaka J., Shiroo M., Yeul Y.D., Migita S.;
RT   "Structural diversity of murine serum amyloid A genes. Evolutionary
RT   implications.";
RL   J. Immunol. 139:1683-1688(1987).
RN   [4]
RP   PROTEIN SEQUENCE OF 20-122.
RC   STRAIN=SJL/J;
RX   PubMed=1590757; DOI=10.1042/bj2830673;
RA   de Beer M.C., de Beer F.C., Beach C.M., Carreras I., Sipe J.D.;
RT   "Mouse serum amyloid A protein. Complete amino acid sequence and mRNA
RT   analysis of a new isoform.";
RL   Biochem. J. 283:673-678(1992).
CC   -!- FUNCTION: Major acute phase reactant. {ECO:0000250|UniProtKB:P05366}.
CC   -!- SUBUNIT: Apolipoprotein of the HDL complex.
CC       {ECO:0000250|UniProtKB:P0DJI8}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0DJI8}.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
CC       {ECO:0000269|PubMed:3013853}.
CC   -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
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DR   EMBL; M13522; AAA40086.1; -; Genomic_DNA.
DR   EMBL; M11130; AAA40085.1; -; mRNA.
DR   EMBL; M17791; AAA40087.1; -; Genomic_DNA.
DR   CCDS; CCDS21285.1; -.
DR   PIR; B23843; B23843.
DR   RefSeq; NP_035444.1; NM_011314.2.
DR   RefSeq; XP_006540790.1; XM_006540727.2.
DR   PDB; 6DSO; EM; 3.00 A; A/B/C/D/E/F/G/H/I/J/K/L=20-102.
DR   PDB; 6ZCF; EM; 2.73 A; A/B/C/D/E/F/G/H/I/J/K/L=20-122.
DR   PDB; 6ZCG; EM; 2.95 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=20-122.
DR   PDB; 6ZCH; EM; 3.50 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=20-102.
DR   PDB; 7OVT; EM; 2.69 A; A/B/C/D/E/F/G/H/I/J/K/L=20-122.
DR   PDBsum; 6DSO; -.
DR   PDBsum; 6ZCF; -.
DR   PDBsum; 6ZCG; -.
DR   PDBsum; 6ZCH; -.
DR   PDBsum; 7OVT; -.
DR   AlphaFoldDB; P05367; -.
DR   SMR; P05367; -.
DR   BioGRID; 203062; 1.
DR   STRING; 10090.ENSMUSP00000075365; -.
DR   PhosphoSitePlus; P05367; -.
DR   CPTAC; non-CPTAC-3944; -.
DR   MaxQB; P05367; -.
DR   PaxDb; P05367; -.
DR   PeptideAtlas; P05367; -.
DR   PRIDE; P05367; -.
DR   ProteomicsDB; 255451; -.
DR   DNASU; 20209; -.
DR   Ensembl; ENSMUST00000075982; ENSMUSP00000075365; ENSMUSG00000057465.
DR   Ensembl; ENSMUST00000210769; ENSMUSP00000147751; ENSMUSG00000057465.
DR   GeneID; 20209; -.
DR   KEGG; mmu:20209; -.
DR   UCSC; uc009gzb.2; mouse.
DR   CTD; 6289; -.
DR   MGI; MGI:98222; Saa2.
DR   VEuPathDB; HostDB:ENSMUSG00000057465; -.
DR   eggNOG; ENOG502S4PB; Eukaryota.
DR   GeneTree; ENSGT00390000004737; -.
DR   HOGENOM; CLU_129936_0_0_1; -.
DR   InParanoid; P05367; -.
DR   OMA; MREANWI; -.
DR   OrthoDB; 1417043at2759; -.
DR   PhylomeDB; P05367; -.
DR   TreeFam; TF332544; -.
DR   BioGRID-ORCS; 20209; 5 hits in 40 CRISPR screens.
DR   ChiTaRS; Saa1; mouse.
DR   PRO; PR:P05367; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; P05367; protein.
DR   Bgee; ENSMUSG00000057465; Expressed in left lobe of liver and 71 other tissues.
DR   ExpressionAtlas; P05367; baseline and differential.
DR   Genevisible; P05367; MM.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISO:MGI.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; ISO:MGI.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; ISO:MGI.
DR   GO; GO:0048246; P:macrophage chemotaxis; ISO:MGI.
DR   GO; GO:0045785; P:positive regulation of cell adhesion; ISO:MGI.
DR   GO; GO:0001819; P:positive regulation of cytokine production; ISO:MGI.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR   GO; GO:0035634; P:response to stilbenoid; IEP:UniProtKB.
DR   InterPro; IPR000096; Serum_amyloid_A.
DR   Pfam; PF00277; SAA; 1.
DR   PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR   PRINTS; PR00306; SERUMAMYLOID.
DR   SMART; SM00197; SAA; 1.
DR   PROSITE; PS00992; SAA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acute phase; Amyloid; Direct protein sequencing; HDL;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:1590757"
FT   CHAIN           20..122
FT                   /note="Serum amyloid A-2 protein"
FT                   /evidence="ECO:0000269|PubMed:1590757"
FT                   /id="PRO_0000031589"
FT   CHAIN           20..94
FT                   /note="Amyloid protein A"
FT                   /evidence="ECO:0000250|UniProtKB:P0DJI9"
FT                   /id="PRO_0000031590"
FT   REGION          89..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..109
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         120
FT                   /note="A -> D (in strain: SJL/J)"
FT   STRAND          21..33
FT                   /evidence="ECO:0007829|PDB:6ZCF"
FT   STRAND          38..44
FT                   /evidence="ECO:0007829|PDB:6ZCF"
FT   STRAND          46..48
FT                   /evidence="ECO:0007829|PDB:6ZCF"
FT   STRAND          52..55
FT                   /evidence="ECO:0007829|PDB:6ZCF"
FT   STRAND          63..65
FT                   /evidence="ECO:0007829|PDB:6DSO"
FT   STRAND          70..72
FT                   /evidence="ECO:0007829|PDB:6DSO"
FT   STRAND          74..78
FT                   /evidence="ECO:0007829|PDB:6DSO"
FT   STRAND          83..87
FT                   /evidence="ECO:0007829|PDB:6DSO"
SQ   SEQUENCE   122 AA;  13622 MW;  99E79D6FF97E96E0 CRC64;
     MKLLTSLVFC SLLLGVCHGG FFSFIGEAFQ GAGDMWRAYT DMKEAGWKDG DKYFHARGNY
     DAAQRGPGGV WAAEKISDAR ESFQEFFGRG HEDTMADQEA NRHGRSGKDP NYYRPPGLPA
     KY