ID   SAA2_NEOVI              Reviewed;         129 AA.
AC   P02739;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Serum amyloid A-2 protein {ECO:0000250|UniProtKB:P0DJI9};
DE   Contains:
DE     RecName: Full=Amyloid protein AA1 {ECO:0000303|PubMed:6767608};
DE     AltName: Full=Protein AA1 {ECO:0000303|PubMed:6767608};
DE              Short=AA1 {ECO:0000303|PubMed:6767608};
DE   Contains:
DE     RecName: Full=Amyloid protein AA2 {ECO:0000303|PubMed:6767608};
DE     AltName: Full=Protein AA2 {ECO:0000303|PubMed:6767608};
DE              Short=AA2 {ECO:0000303|PubMed:6767608};
DE   Flags: Precursor;
GN   Name=SAA2P0DJI9;
OS   Neovison vison (American mink) (Mustela vison).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Mustelinae;
OC   Neogale.
OX   NCBI_TaxID=452646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Liver;
RX   PubMed=2351648; DOI=10.1016/s0021-9258(19)38777-0;
RA   Marhaug G., Husby G., Dowton S.B.;
RT   "Mink serum amyloid A protein. Expression and primary structure based on
RT   cDNA sequences.";
RL   J. Biol. Chem. 265:10049-10054(1990).
RN   [2]
RP   PROTEIN SEQUENCE OF 19-82, PROTEIN SEQUENCE OF 19-71, PYROGLUTAMATE
RP   FORMATION AT GLN-19, AND TISSUE SPECIFICITY.
RX   PubMed=6767608; DOI=10.1111/j.1432-1033.1980.tb04441.x;
RA   Waalen K., Sletten K., Husby G., Nordstoga K.;
RT   "The primary structure of amyloid fibril protein AA in endotoxin-induced
RT   amyloidosis of the mink.";
RL   Eur. J. Biochem. 104:407-412(1980).
CC   -!- FUNCTION: Major acute phase reactant. {ECO:0000250|UniProtKB:P05366}.
CC   -!- SUBUNIT: Apolipoprotein of the HDL complex.
CC       {ECO:0000250|UniProtKB:P0DJI8}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0DJI8}.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
CC       {ECO:0000269|PubMed:2351648, ECO:0000269|PubMed:6767608}.
CC   -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
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DR   EMBL; M34954; AAA30969.1; -; mRNA.
DR   PIR; A03199; YLMNA.
DR   PIR; B36451; B36451.
DR   AlphaFoldDB; P02739; -.
DR   SMR; P02739; -.
DR   Proteomes; UP000694425; Unplaced.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR000096; Serum_amyloid_A.
DR   Pfam; PF00277; SAA; 1.
DR   PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR   PRINTS; PR00306; SERUMAMYLOID.
DR   SMART; SM00197; SAA; 1.
DR   PROSITE; PS00992; SAA; 1.
PE   1: Evidence at protein level;
KW   Acute phase; Amyloid; Direct protein sequencing; HDL;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000269|PubMed:6767608"
FT   CHAIN           19..129
FT                   /note="Serum amyloid A-2 protein"
FT                   /id="PRO_0000031594"
FT   CHAIN           19..82
FT                   /note="Amyloid protein AA1"
FT                   /evidence="ECO:0000269|PubMed:6767608"
FT                   /id="PRO_0000031595"
FT   CHAIN           19..71
FT                   /note="Amyloid protein AA2"
FT                   /evidence="ECO:0000269|PubMed:6767608"
FT                   /id="PRO_0000450362"
FT   REGION          92..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..106
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         19
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:6767608"
FT   VARIANT         24
FT                   /note="I -> F"
SQ   SEQUENCE   129 AA;  14456 MW;  B79402006B34B882 CRC64;
     MKLFTGLIFC SLVLGVSSQW YSFIGEAVQG AWDMYRAYSD MREANYKNSD KYFHARGNYD
     AAQRGPGGAW AAKVISDARE RSQRVTDLFK YGDSGHGVED SKADQAANEW GRSGKDPNHF
     RPSGLPDKY